日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

EGFR-mutant transformed small cell lung cancer harbors intratumoral heterogeneity targetable with MEK inhibitor combination therapy.

EGFR突变型小细胞肺癌具有肿瘤内异质性,可通过MEK抑制剂联合疗法进行靶向治疗。

Ogino Atsuko, Vajdi Amir, Mu Xinmeng Jasmine, Mahadevan Navin R, Ngo Kenneth, Booker Matthew A, Cejas Paloma, Okoro Jeffrey J, Xu Man, Springer Benjamin F, Eschle Benjamin K, Messier Cameron M, Wang Stephen, Syamala Sudeepa, Tamen Rubii M, Adeni Anika E, Chambers Emily S, Canadas Israel, Thai Tran, Christensen Camilla L, Xu Chunxiao, Lizotte Patrick H, Oxnard Geoffrey R, Watanabe Hideo, Long Henry W, Gokhale Prafulla C, Paweletz Cloud P, Sholl Lynette M, Oser Matthew G, Barbie David A, Tolstorukov Michael Y, Jänne Pasi A

Eradicating Drug-tolerant Persister Cells in EGFR-Mutated Non-Small Cell Lung Cancer by Targeting TROP2 with CAR-T Cellular Therapy

利用CAR-T细胞疗法靶向TROP2,根除EGFR突变型非小细胞肺癌中的耐药性持续细胞

Simon Baldacci ,Elliott J Brea ,Francesco Facchinetti ,Zhaorong Li ,Kenneth Ngo ,Soumya Malhotra ,Matthew A Booker ,Michael Yevgeniy Tolstorukov ,Sachiv Chakravarti ,Conor Hinchey ,Navin R Mahadevan ,Filippo Lococo ,Simona D'Agnelli ,Letizia Gnetti ,Nicoletta Campanini ,Alessandro Leonetti ,William W Feng ,Jeanelle A Tsai ,Antja-Voy Hartley ,Marie-Anaïs Locquet ,Ludovic Fournel ,Marco Alifano ,Audrey Mansuet-Lupo ,Aisha Saldanha ,William Haller ,Lauren M Zasadil ,Magdalena Zielinska ,Karen Bui ,Bishma Tuladhar ,Patrick Hall Lizotte ,Elena V Ivanova ,Lecia V Sequist ,Prafulla C Gokhale ,Cloud P Paweletz ,Eric L Smith ,Pasi A Jänne ,David A Barbie

Tamoxifen induces PI3K activation in uterine cancer.

他莫昔芬可诱导子宫癌细胞中PI3K活化。

Kübler Kirsten, Nardone Agostina, Anand Shankara, Gurevich Daniel, Gao Jianjiong, Droog Marjolein, Hermida-Prado Francisco, Akhshi Tara, Feiglin Ariel, Feit Avery S, Cohen Feit Gabriella, Dackus Gwen, Pun Matthew, Kuang Yanan, Cha Justin, Miller Mendy, Gregoricchio Sebastian, Lanfermeijer Mirthe, Cornelissen Sten, Gibson William J, Paweletz Cloud P, Van Allen Eliezer M, van Leeuwen Flora E, Nederlof Petra M, Nguyen Quang-Dé, Mourits Marian J E, Radovich Milan, Leshchiner Ignaty, Stewart Chip, Matulonis Ursula A, Zwart Wilbert, Maruvka Yosef E, Getz Gad, Jeselsohn Rinath

Immune targeting of triple-negative breast cancer through a clinically actionable STING agonist-CAR T cell platform

利用临床可操作的STING激动剂-CAR T细胞平台进行三阴性乳腺癌的免疫靶向治疗

Yuqing Zhang,Zehua Li,Jessica Ritter,Elliott J Brea,Navin R Mahadevan,Deborah A Dillon,Sung-Rye Park,Eric Minwei Liu,Michael Y Tolstorukov,William E McGourty,Patrick Lizotte,Elena V Ivanova,Caroline Fahey,Koji Haratani,Tran C Thai,Kara M Soroko,Sophie Kivlehan,Eric L Smith,Prafulla C Gokhale,Cloud P Paweletz,David A Barbie,Thanh U Barbie

Round-Robin Comparison of RET Rearrangement Detection in ctDNA: A Novel Method for Limited Clinical Samples

循环肿瘤DNA中RET重排检测的比较研究:一种适用于有限临床样本的新方法

Paweletz, Cloud P; Urvalek, Alison; Ha, Minh; Garg, Kavita; Bence Lin, Aimee; Szpurka, Anna M; Sireci, Anthony; Oxnard, Geoffrey R; Janne, Pasi A

Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies

发现BMS-986408,一种首创的双重DGKα和DGKζ抑制剂,可激活PD-1检查点和CAR T细胞免疫疗法

Michael Wichroski #,Si-Qi Liu #,Lauren M Zasadil,Joseph L Benci,Patrick C Gedeon,Kendall J Condon,Suhasini Joshi,Shana Posy,Patrick Carlson,Alison Maier,Jiao Shen,Rakeeb Kureshi,Yuka Amako,Tai Wang,Ryan L Powles,Yanyun Li,Tho Lai,Igor Katsyv,Hongchen Qiu,Huilin Qi,Jessica Wong,Dandan Zhao,Dana Banas,Joelle Onorato,Gregory Locke,Xueer Chen,Wen-Chi Chou,Erica Cook,Abigail E Witt,Christopher M Barbieri,Hong Zhang,Jonathan B Olsen,Alba Font Tello,Eugene Drokhlyansky,Denise C Grünenfelder,Louis Chupak,Tyler A Longmire,Jon C Jones,Travis J Hollmann,David G Kugler,John N Feder,Raphael Bueno,John Wain,Pallavur Sivakumar,Yu Liu,Stephanie K Dougan,Cloud P Paweletz,David A Barbie,Emma Lees

Systematic Engineering of TROP2-Targeted CAR T-Cell Therapy Overcomes Resistance Pathways in Solid Tumors

系统性改造TROP2靶向CAR T细胞疗法可克服实体瘤的耐药通路

Elliott J Brea,Simon Baldacci,Neil Savage,Francesco Facchinetti,Conor Hinchey,Sachiv Chakravarti,Alexis Mottram,Kenneth Ngo,Ha Vo,Brittaney A Leeper,Bishma Tuladhar,Suthakar Ganapathy,Elena V Ivanova,Aisha Saldanha,Marie-Anais Locquet,Abdulmajeed Salamah,Malcolm Holterhus,Evelyn B Mesler,Martina De Vizio,Carla Stornante,Marco Campisi,Navin R Mahadevan,Tran C Thai,Timothy J Haggerty,Zehua Li,Cui Nie,Changjing Deng,Xiaoxiao Wang,Louis L Liu,Thanh U Barbie,Prafulla C Gokhale,Cloud P Paweletz,Anusuya Ramasubramanian,Pasi A Jänne,David A Barbie,Eric L Smith

Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies

发现BMS-986408,一种首创的双重DGKα和DGKζ抑制剂,可激活PD-1检查点和CAR T细胞免疫疗法

Michael Wichroski # ,Si-Qi Liu # ,Lauren M Zasadil ,Joseph L Benci ,Patrick C Gedeon ,Kendall J Condon ,Suhasini Joshi ,Shana Posy ,Patrick Carlson ,Alison Maier ,Jiao Shen ,Rakeeb Kureshi ,Yuka Amako ,Tai Wang ,Ryan L Powles ,Yanyun Li ,Tho Lai ,Igor Katsyv ,Hongchen Qiu ,Huilin Qi ,Jessica Wong ,Dandan Zhao ,Dana Banas ,Joelle Onorato ,Gregory Locke ,Xueer Chen ,Wen-Chi Chou ,Erica Cook ,Abigail E Witt ,Christopher M Barbieri ,Hong Zhang ,Jonathan B Olsen ,Alba Font Tello ,Eugene Drokhlyansky ,Denise C Grünenfelder ,Louis Chupak ,Tyler A Longmire ,Jon C Jones ,Travis J Hollmann ,David G Kugler ,John N Feder ,Raphael Bueno ,John Wain ,Pallavur Sivakumar ,Yu Liu ,Stephanie K Dougan ,Cloud P Paweletz ,David A Barbie ,Emma Lees

Functional Characterization and a Real-World Clinical Laboratory Pilot of the Foundation for the National Institutes of Health Circulating Tumor DNA Quality Control Materials

美国国立卫生研究院基金会循环肿瘤DNA质量控制材料的功能表征和真实世界临床实验室试点项目

Paweletz, Cloud P; Forbes, Thomas D; Yee, Laura; Heavey, Grace; He, Hua-Jun; He, Zhiyong; Connors, Dana; Stetson, Daniel; Keating, Susan; Cole, Kenneth D; Chen, Li; Pauly, Rini; Bao, Hua; Wu, Xue; Pestano, Gary A; Weaver, Amanda L; Kohli, Manish; Hellwig, Sabine; Corner, Adam S; Prantner, Andrew M; Wong, Stephen Q; Fox, Stephen B; Hewitt, Chelsee A; Arnolda, Rainier; Jones, Greg R; Craft, Jonathan; McConechy, Melissa; Qahtani, Mawath A; Klemm, Florian; Mohammad, Fuad; Sigman, Caroline; Liu, Liang-Chun; Gan, Qiang; Konigshofer, Yves; Garlick, Russell; Chin, Ephrem; Kelloff, Gary; Williams, P Mickey; McCormack, Robert; Karlovich, Chris

Somatic Activating ESR1 Mutation in an Aggressive Prolactinoma

侵袭性催乳素瘤中的体细胞激活ESR1突变

Paes, Ticiana; Buelvas Mebarak, Jacobo; Magnotto, John C; Stamatiades, George A; Kuang, Yanan; Paweletz, Cloud P; Laws, Edward R; Grosek, Natalie; Carroll, Rona S; Jeselsohn, Rinath; Mohan, Dipika R; Marcondes Lerario, Antonio; Truong, Minh T; Bi, Wenya Linda; Reardon, David A; Meredith, David M; Kaiser, Ursula B; Abreu, Ana Paula