日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective and brain-penetrant ACSS2 inhibitors target breast cancer brain metastatic cells

选择性和脑渗透性 ACSS2 抑制剂靶向乳腺癌脑转移细胞

Emily M Esquea, Lorela Ciraku, Riley G Young, Jessica Merzy, Alexandra N Talarico, Nusaiba N Ahmed, Mangalam Karuppiah, Anna Ramesh, Adam Chatoff, Claudia V Crispim, Adel A Rashad, Simon Cocklin, Nathaniel W Snyder, Joris Beld, Nicole L Simone, Mauricio J Reginato, Alexej Dick

Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators

新型含喹唑啉-4-酮骨架的苯丙氨酸衍生物作为强效HIV衣壳调节剂的发现、晶体学研究和机理研究

Xu, Shujing; Sun, Lin; Barnett, Michael; Zhang, Xujie; Ding, Dang; Gattu, Anushka; Shi, Dazhou; Taka, Jamie R H; Shen, Wenli; Jiang, Xiangyi; Cocklin, Simon; De Clercq, Erik; Pannecouque, Christophe; Goldstone, David C; Liu, Xinyong; Dick, Alexej; Zhan, Peng

Defining genetic diversity of rhesus macaque Fcγ receptors with long-read RNA sequencing

利用长读长RNA测序确定恒河猴Fcγ受体的遗传多样性

Conley, Haleigh E; He, Max M; Easterhoff, David; Kirshner, Hélène Fradin; Cocklin, Sarah L; Meyer, Jacob; Hoxie, Taylor; Berry, Madison; Bradley, Todd; Tolbert, William D; Pazgier, Marzena; Tomaras, Georgia D; Schmitz, Joern E; Moody, Michael Anthony; Wiehe, Kevin; Pollara, Justin

Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators.

2-哌嗪酮肽模拟物作为新型 HIV 衣壳调节剂的设计、合成和机理研究

Zhang Xujie, Sun Lin, Xu Shujing, Huang Tianguang, Zhao Fabao, Ding Dang, Liu Chuanfeng, Jiang Xiangyi, Tao Yucen, Kang Dongwei, De Clercq Erik, Pannecouque Christophe, Cocklin Simon, Dick Alexej, Liu Xinyong, Zhan Peng

Discovery of novel brain permeable human ACSS2 inhibitors for blocking breast cancer brain metastatic growth

发现新型可穿透血脑屏障的人ACSS2抑制剂,用于阻断乳腺癌脑转移生长

Esquea, Emily; Ciraku, Lorela; Young, Riley G; Merzy, Jessica; Talarico, Alexandra N; Rashad, Adel Ahmed; Cocklin, Simon; Simone, Nicole L; Beld, Joris; Reginato, Mauricio J; Dick, Alexej

Pandemic's silver lining

疫情带来的意外收获

Ferrara, Fortunato; D'Angelo, Sara; Erasmus, M Frank; Teixeira, André A; Leal-Lopes, Camila; Spector, Laura P; Pohl, Tom; Fanni, Adeline; Cocklin, Simon; Bradbury, Andrew R M

Discovery of novel 1,2,4-triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein

发现靶向HIV衣壳蛋白亚基间口袋内未探索区域的新型1,2,4-三唑苯丙氨酸衍生物

Jiang, Xiangyi; Sharma, Prem Prakash; Rathi, Brijesh; Ji, Xiangkai; Hu, Lide; Gao, Zhen; Kang, Dongwei; Wang, Zhao; Xie, Minghui; Xu, Shujing; Zhang, Xujie; De Clercq, Erik; Cocklin, Simon; Pannecouque, Christophe; Dick, Alexej; Liu, Xinyong; Zhan, Peng

Copper Modulates the Catalytic Activity of Protein Kinase CK2

铜调节蛋白激酶 CK2 的催化活性

John E Chojnowski, Rongrong Li, Tiffany Tsang, Fatimah H Alfaran, Alexej Dick, Simon Cocklin, Donita C Brady, Todd I Strochlic

Rapid Optimization of the Metabolic Stability of a Human Immunodeficiency Virus Type-1 Capsid Inhibitor Using a Multistep Computational Workflow

使用多步计算工作流程快速优化人类免疫缺陷病毒 1 型衣壳抑制剂的代谢稳定性

Megan E Meuser, Poli Adi Narayana Reddy, Alexej Dick, Jean Marc Maurancy, Joseph M Salvino, Simon Cocklin

Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors.

二聚苯丙氨酸衍生物作为新型 HIV-1 衣壳抑制剂的设计、合成和机理研究

Zhang Xujie, Sun Lin, Meuser Megan E, Zalloum Waleed A, Xu Shujing, Huang Tianguang, Cherukupalli Srinivasulu, Jiang Xiangyi, Ding Xiao, Tao Yucen, Kang Dongwei, De Clercq Erik, Pannecouque Christophe, Dick Alexej, Cocklin Simon, Liu Xinyong, Zhan Peng