日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural Analysis of the Complex of Human Transthyretin with 3',5'-Dichlorophenylanthranilic Acid at 1.5 Å Resolution

人转甲状腺素蛋白与3',5'-二氯苯基邻氨基苯甲酸复合物的1.5 Å分辨率结构分析

Cody, Vivian; Truong, Jia Q; Holdsworth, Bruce A; Holien, Jessica K; Richardson, Samantha J; Chalmers, David K; Craik, David J

Three-Dimensional Modeling of Thyroid Hormone Metabolites Binding to the Cancer-Relevant αvβ3 Integrin: In-Silico Based Study

甲状腺激素代谢物与癌症相关αvβ3整合素结合的三维建模:基于计算机模拟的研究

Tobi, Dror; Krashin, Eilon; Davis, Paul J; Cody, Vivian; Ellis, Martin; Ashur-Fabian, Osnat

Protein and RNA dynamical fingerprinting

蛋白质和RNA动态指纹图谱

Niessen, Katherine A; Xu, Mengyang; George, Deepu K; Chen, Michael C; Ferré-D'Amaré, Adrian R; Snell, Edward H; Cody, Vivian; Pace, James; Schmidt, Marius; Markelz, Andrea G

Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection

开发取代吡啶并[3,2-d]嘧啶类化合物作为强效且选择性的二氢叶酸还原酶抑制剂,用于治疗肺孢子菌肺炎感染

Shah, Khushbu; Queener, Sherry; Cody, Vivian; Pace, Jim; Gangjee, Aleem

Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents

针对物种特异性氨基酸残基:6-取代吡咯并[2,3-d]嘧啶类化合物作为二氢叶酸还原酶抑制剂和潜在抗机会性感染药物的设计、合成及生物学评价

Shah, Khushbu; Lin, Xin; Queener, Sherry F; Cody, Vivian; Pace, Jim; Gangjee, Aleem

Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase

三种吡啶并[2,3-d]嘧啶类抗叶酸药物与人及卡氏肺孢子虫二氢叶酸还原酶结合的构效关系

Cody, Vivian; Pace, Jim; Namjoshi, Ojas A; Gangjee, Aleem

Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles

新型吡啶并[2,3-d]嘧啶类似物作为抗叶酸剂的设计、合成和分子建模;杂环化合物的Buchwald-Hartwig胺化反应的应用

Gangjee, Aleem; Namjoshi, Ojas A; Raghavan, Sudhir; Queener, Sherry F; Kisliuk, Roy L; Cody, Vivian

Kinetic and structural analysis for potent antifolate inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and human dihydrofolate reductases and their active-site variants

对卡氏肺孢子虫、卡氏肺孢子虫和人二氢叶酸还原酶及其活性位点变体的强效抗叶酸抑制剂进行动力学和结构分析

Cody, Vivian; Pace, Jim; Queener, Sherry F; Adair, Ona O; Gangjee, Aleem

Small molecule hormone or hormone-like ligands of integrin αVβ3: implications for cancer cell behavior

整合素αVβ3的小分子激素或激素样配体:对癌细胞行为的影响

Davis, Paul J; Mousa, Shaker A; Cody, Vivian; Tang, Heng-Yuan; Lin, Hung-Yun

Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode

对人二氢叶酸还原酶与强效选择性抑制剂2,4-二氨基-6-{2'-O-(3-羧丙基)氧基二苯并[b,f]氮杂卓-5-基}甲基蝶啶形成的二元复合物的结构分析揭示了一种不寻常的结合模式

Cody, Vivian; Pace, Jim; Nowak, Jessica