日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding.

通过转录抑制和直接 CAG 重复序列结合抑制亨廷顿病体细胞不稳定性。

Mathews Ella W, Coffey Sydney R, Gärtner Annette, Belgrad Jillian, Bragg Robert M, O'Reilly Daniel, Cantle Jeffrey P, McHugh Cassandra, Summers Ashley, Fentz Joachim, Schwagarus Tom, Cornelius Antje, Lingos Ioannis, Burch Zoe, Kovalenko Marina, Andrew Marissa A, Bennett C Frank, Kordasiewicz Holly B, Marchionini Deanna M, Wilkinson Hilary, Vogt Thomas F, Beuzer Paolo, Pinto Ricardo M, Khvorova Anastasia, Howland David, Wheeler Vanessa C, Carroll Jeffrey B

Altered huntingtin-chromatin interactions predict transcriptional and epigenetic changes in Huntington's disease.

亨廷顿蛋白-染色质相互作用的改变可预测亨廷顿病中的转录和表观遗传变化

Pearl Jocelynn R, Shetty Amol C, Cantle Jeffrey P, Bergey Dani E, Bragg Robert M, Coffey Sydney R, Kordasiewicz Holly B, Hood Leroy E, Price Nathan D, Ament Seth A, Carroll Jeffrey B

Stool is a sensitive and noninvasive source of DNA for monitoring expansion in repeat expansion disease mouse models

粪便是一种灵敏且无创的DNA来源,可用于监测重复序列扩增疾病小鼠模型中的扩增情况。

Zhao, Xiaonan; McHugh, Cassandra; Coffey, Sydney R; Jimenez, Diego Antonio; Adams, Elizabeth; Carroll, Jeffrey B; Usdin, Karen

Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations

单核RNA测序揭示亨廷顿病突变导致纹状体细胞身份失调

Malaiya, Sonia; Cortes-Gutierrez, Marcia; Herb, Brian R; Coffey, Sydney R; Legg, Samuel R W; Cantle, Jeffrey P; Colantuoni, Carlo; Carroll, Jeffrey B; Ament, Seth A

Corrigendum: Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.Htt(Q111/+) model of Huntington's disease

更正:在亨廷顿病B6.Htt(Q111/+)模型中,动机、蛋白质稳态和转录缺陷先于突触丢失、胶质增生和神经退行性变发生。

Bragg, Robert M; Coffey, Sydney R; Weston, Rory M; Ament, Seth A; Cantle, Jeffrey P; Minnig, Shawn; Funk, Cory C; Shuttleworth, Dominic D; Woods, Emily L; Sullivan, Bonnie R; Jones, Lindsey; Glickenhaus, Anne; Anderson, John S; Anderson, Michael D; Dunnett, Stephen B; Wheeler, Vanessa C; MacDonald, Marcy E; Brooks, Simon P; Price, Nathan D; Carroll, Jeffrey B

Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington's disease

在亨廷顿病B6.HttQ111/+小鼠模型中,外周亨廷顿蛋白沉默并不能改善中枢疾病症状。

Coffey, Sydney R; Bragg, Robert M; Minnig, Shawn; Ament, Seth A; Cantle, Jeffrey P; Glickenhaus, Anne; Shelnut, Daniel; Carrillo, José M; Shuttleworth, Dominic D; Rodier, Julie-Anne; Noguchi, Kimihiro; Bennett, C Frank; Price, Nathan D; Kordasiewicz, Holly B; Carroll, Jeffrey B