日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GLP-1R biased cAMP agonism maintains glycemic control with reduced malaise and emesis in preclinical mammalian models

在临床前哺乳动物模型中,GLP-1R 偏向性 cAMP 激动剂作用可维持血糖控制,并减少不适和呕吐。

Baumer-Harrison, Caitlin; Aldaghma, Danya; White, Alex D; Applebey, Sarah V; Pataro, Allison M; Mohiby, Allaha Z; Alonso, Brandon; Xiao, Allison G; O'Farrell, Libbey S; Qian, Yuewei; Coskun, Tamer; Coghlan, Matthew P; Willard, Francis S; Ai, Minrong; Sloop, Kyle W; Doyle, Robert P; Borner, Tito; De Jonghe, Bart C; Hayes, Matthew R

The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice.

GIP 受体激活白色脂肪组织中的无效钙循环,从而增加能量消耗并促进小鼠体重减轻

Yu Xinxin, Chen Shiuhwei, Funcke Jan-Bernd, Straub Leon G, Pirro Valentina, Emont Margo P, Droz Brian A, Collins Kyla Ai, Joung Chanmin, Pearson Mackenzie J, James Corey M, Babu Gopal J, Efthymiou Vissarion, Vernon Ashley, Patti Mary Elizabeth, An Yu A, Rosen Evan D, Coghlan Matthew P, Samms Ricardo J, Scherer Philipp E, Kusminski Christine M

Glucose-dependent insulinotropic polypeptide (GIP)

葡萄糖依赖性促胰岛素多肽(GIP)

Müller, Timo D; Adriaenssens, Alice; Ahrén, Bo; Blüher, Matthias; Birkenfeld, Andreas L; Campbell, Jonathan E; Coghlan, Matthew P; D'Alessio, David; Deacon, Carolyn F; DelPrato, Stefano; Douros, Jonathan D; Drucker, Daniel J; Figueredo Burgos, Natalie S; Flatt, Peter R; Finan, Brian; Gimeno, Ruth E; Gribble, Fiona M; Hayes, Matthew R; Hölscher, Christian; Holst, Jens J; Knerr, Patrick J; Knop, Filip K; Kusminski, Christine M; Liskiewicz, Arkadiusz; Mabilleau, Guillaume; Mowery, Stephanie A; Nauck, Michael A; Novikoff, Aaron; Reimann, Frank; Roberts, Anna G; Rosenkilde, Mette M; Samms, Ricardo J; Scherer, Philip E; Seeley, Randy J; Sloop, Kyle W; Wolfrum, Christian; Wootten, Denise; DiMarchi, Richard D; Tschöp, Matthias H

Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region

基因预测的葡萄糖依赖性胰岛素促泌多肽 (GIP) 水平和心血管疾病风险是由 GIPR 区域中不同的致病变异驱动的

Bowker, Nicholas; Hansford, Robert; Burgess, Stephen; Foley, Christopher N; Auyeung, Victoria P W; Erzurumluoglu, A Mesut; Stewart, Isobel D; Wheeler, Eleanor; Pietzner, Maik; Gribble, Fiona; Reimann, Frank; Bhatnagar, Pallav; Coghlan, Matthew P; Wareham, Nicholas J; Langenberg, Claudia