日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Potent and dose-sparing next-generation SARS-CoV-2 vaccine, mRNA-1283, induces polyfunctional and durable T cell immunity

高效且剂量节省的下一代SARS-CoV-2疫苗mRNA-1283可诱导多功能且持久的T细胞免疫。

Paila, Yamuna D; Pajon, Rolando; Banbury, Barbara; Fields, Paul; Maglinao, Maha; De Rosa, Stephen C; Morris, Daryl; McElrath, M Juliana; Siangphoe, Uma; Cohen, Kristen W; Paris, Robert

Coordinated immune response distinguishes duration of SARS-CoV-2 viral particle shedding in humans

协调的免疫反应决定了SARS-CoV-2病毒颗粒在人体内的脱落持续时间。

Schuster, Daniel J; Li, Shuying S; Mielke, Dieter; Seaton, Kelly E; Brackett, Caroline; Li, Kan; Shen, Xiaoying; Wesley, Martina S; Eisel, Nathan; Yates, Nicole L; Zhang, Lu; Sawant, Sheetal; De Rosa, Stephen C; Cohen, Kristen W; Stanfield-Oakley, Sherry; Sholukh, Anton M; Germain, Russell St; Li, Xiaohong; Hu, Jiani; Premkumar, Lakshmanane; Gallardo-Cartagena, Jorge A; Randhawa, April Kaur; Dennison, S Moses; Hural, John A; Corey, Lawrence; Karuna, Shelly; McElrath, M Juliana; Ferrari, Guido; Hyrien, Ollivier; Tomaras, Georgia D

ALVAC-prime and monomeric gp120 protein boost induces distinct HIV-1 specific humoral and cellular responses compared with adenovirus-prime and trimeric gp140 protein boost

与腺病毒启动和三聚体gp140蛋白增强相比,ALVAC启动和单体gp120蛋白增强可诱导不同的HIV-1特异性体液和细胞免疫反应。

Fisher, Leigh H; Lazarus, Erica; Yu, Chenchen; Moodie, Zoe; Stieh, Daniel J; Yates, Nicole; Zhang, Lu; Sawant, Sheetal; De Rosa, Stephen C; Cohen, Kristen W; Morris, Daryl; Grant, Shannon; Randhawa, April; Miner, Maurine D; Hendriks, Jenny; Wegmann, Frank; Gill, Katherine M; Laher, Fatima; Bekker, Linda-Gail; Gray, Glenda E; Corey, Lawrence; McElrath, M Juliana; Martin, Troy; Gilbert, Peter B; Tomaras, Georgia; Walsh, Stephen R; Baden, Lindsey R

Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial

在一项 I 期临床试验中,接种 mRNA 编码的膜锚定 HIV 包膜三聚体疫苗可诱导产生 2 级中和抗体。

Parks, K Rachael; Moodie, Zoe; Allen, Mary A; Yen, Catherine; Furch, Briana D; MacPhee, Kellie J; Ozorowski, Gabriel; Heptinstall, Jack; Hahn, William O; Zheng, Zihan; Lu, Huiyin; Grant, Shannon; Domin, Elize; Duff, Michael O; Seese, Aaron; Marini-Macouzet, Constanza; Ballweber-Fleming, Lamar; Lee, Wen-Hsin; Cottrell, Christopher A; Liguori, Alessia; Georgeson, Erik; Alavi, Nushin; Kubitz, Michael; Phelps, Nicole; Seaton, Kelly E; Cohen, Kristen W; Anderson, Maija A; Mondal, Kajari; Laufer, Dagna S; Kublin, James G; Ward, Andrew B; Hyrien, Ollivier; De Rosa, Stephen C; Himansu, Sunny; Leav, Brett; Reuter, Caroline; Tomaras, Georgia D; Montefiori, David; Walsh, Stephen R; Frank, Ian; Sobieszczyk, Magdalena E; Goepfert, Paul A; Stephenson, Kathryn E; Baden, Lindsey R; Van Tieu, Hong; Keefer, Michael C; Clark, Jesse; Riddler, Sharon A; Schief, William R; McElrath, M Juliana

Distinct immune responses in people living with HIV following SARS-CoV-2 recovery.

HIV感染者在SARS-CoV-2康复后表现出独特的免疫反应

Mielke Dieter, Li Shuying Sue, Schuster Daniel J, Li Xiaohong, Hu Jiani, Karuna Shelly, Seaton Kelly E, Brackett Caroline, Dunn Brooke, Keyes Taylor, Zalaquett Adam, Stanfield-Oakley Sherry, Zhang Lu, Wesley Martina S, Eisel Nathan, Yates Nicole L, Shen Xiaoying, Premkumar Lakshmanane, Germain Russell St, Sholukh Anton M, Cohen Kristen, de Rosa Stephen, Randhawa April Kaur, Hural John A, Corey Lawrence, McElrath M Julianna, Tomaras Georgia D, Hyrien Ollivier, Ferrari Guido

Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming

人类免疫球蛋白基因等位基因变异影响针对种系的疫苗初次免疫。

deCamp, Allan C; Corcoran, Martin M; Fulp, William J; Willis, Jordan R; Cottrell, Christopher A; Bader, Daniel L V; Kalyuzhniy, Oleksandr; Leggat, David J; Cohen, Kristen W; Hyrien, Ollivier; Menis, Sergey; Finak, Greg; Ballweber-Fleming, Lamar; Srikanth, Abhinaya; Plyler, Jason R; Rahaman, Farhad; Lombardo, Angela; Philiponis, Vincent; Whaley, Rachael E; Seese, Aaron; Brand, Joshua; Ruppel, Alexis M; Hoyland, Wesley; Mahoney, Celia R; Cagigi, Alberto; Taylor, Alison; Brown, David M; Ambrozak, David R; Sincomb, Troy; Mullen, Tina-Marie; Maenza, Janine; Kolokythas, Orpheus; Khati, Nadia; Bethony, Jeffrey; Roederer, Mario; Diemert, David; Koup, Richard A; Laufer, Dagna S; McElrath, Juliana M; McDermott, Adrian B; Karlsson Hedestam, Gunilla B; Schief, William R

A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses

首个针对人类生殖系的HIV纳米颗粒疫苗诱导了广泛且具有公共靶向性的辅助性T细胞反应。

Cohen, Kristen W; De Rosa, Stephen C; Fulp, William J; deCamp, Allan C; Fiore-Gartland, Andrew; Mahoney, Celia R; Furth, Sarah; Donahue, Josh; Whaley, Rachael E; Ballweber-Fleming, Lamar; Seese, Aaron; Schwedhelm, Katharine; Geraghty, Daniel; Finak, Greg; Menis, Sergey; Leggat, David J; Rahaman, Farhad; Lombardo, Angela; Borate, Bhavesh R; Philiponis, Vincent; Maenza, Janine; Diemert, David; Kolokythas, Orpheus; Khati, Nadia; Bethony, Jeffrey; Hyrien, Ollivier; Laufer, Dagna S; Koup, Richard A; McDermott, Adrian B; Schief, William R; McElrath, M Juliana

Trivalent mosaic or consensus HIV immunogens prime humoral and broader cellular immune responses in adults

三价嵌合体或共识型HIV免疫原可启动成人体内的体液免疫和更广泛的细胞免疫反应。

Cohen, Kristen W; Fiore-Gartland, Andrew; Walsh, Stephen R; Yusim, Karina; Frahm, Nicole; Elizaga, Marnie L; Maenza, Janine; Scott, Hyman; Mayer, Kenneth H; Goepfert, Paul A; Edupuganti, Srilatha; Pantaleo, Giuseppe; Hutter, Julia; Morris, Daryl E; De Rosa, Stephen C; Geraghty, Daniel E; Robb, Merlin L; Michael, Nelson L; Fischer, Will; Giorgi, Elena E; Malhi, Harman; Pensiero, Michael N; Ferrari, Guido; Tomaras, Georgia D; Montefiori, David C; Gilbert, Peter B; McElrath, M Juliana; Haynes, Barton F; Korber, Bette T; Baden, Lindsey R

Safety and Immunogenicity of Ad26-Vectored HIV Vaccine With Mosaic Immunogens and a Novel Mosaic Envelope Protein in HIV-Uninfected Adults: A Phase 1/2a Study

一项针对未感染 HIV 的成年人的 1/2a 期研究:以 Ad26 为载体、含有嵌合免疫原和新型嵌合包膜蛋白的 HIV 疫苗的安全性和免疫原性

Stieh, Daniel J; Barouch, Dan H; Comeaux, Christy; Sarnecki, Michal; Stephenson, Kathryn E; Walsh, Stephen R; Sawant, Sheetal; Heptinstall, Jack; Tomaras, Georgia D; Kublin, James G; McElrath, M Juliana; Cohen, Kristen W; De Rosa, Stephen C; Alter, Galit; Ferrari, Guido; Montefiori, David; Mann, Philipp; Nijs, Steven; Callewaert, Katleen; Goepfert, Paul A; Edupuganti, Srilatha; Karita, Etienne; Seaman, Michael S; Corey, Lawrence; Baden, Lindsey R; Pau, Maria G; Schuitemaker, Hanneke; Tomaka, Frank

Safety and immunogenicity of a recombinant oligomeric gp145 subtype C Env protein (gp145 C.6980) HIV vaccine candidate in healthy, HIV-1-uninfected adult participants in the US

在美国健康、未感染HIV-1的成年受试者中,重组寡聚gp145亚型C Env蛋白(gp145 C.6980)HIV候选疫苗的安全性和免疫原性

Tieu, Hong-Van; Karuna, Shelly; Huang, Yunda; Sobieszczyk, Magdalena E; Zheng, Hua; Tomaras, Georgia D; Montefiori, David C; Shen, Mingchao; DeRosa, Stephen; Cohen, Kristen; Isaacs, Margaret Brewinski; Regenold, Stephanie; Heptinstall, Jack; Seaton, Kelly E; Sawant, Sheetal; Furch, Brianna; Pensiero, Michael; Corey, Lawrence; Bar, Katharine J