日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Potent and dose-sparing next-generation SARS-CoV-2 vaccine, mRNA-1283, induces polyfunctional and durable T cell immunity

高效且剂量节省的下一代SARS-CoV-2疫苗mRNA-1283可诱导多功能且持久的T细胞免疫。

Paila, Yamuna D; Pajon, Rolando; Banbury, Barbara; Fields, Paul; Maglinao, Maha; De Rosa, Stephen C; Morris, Daryl; McElrath, M Juliana; Siangphoe, Uma; Cohen, Kristen W; Paris, Robert

Coordinated immune response distinguishes duration of SARS-CoV-2 viral particle shedding in humans

协调的免疫反应决定了SARS-CoV-2病毒颗粒在人体内的脱落持续时间。

Schuster, Daniel J; Li, Shuying S; Mielke, Dieter; Seaton, Kelly E; Brackett, Caroline; Li, Kan; Shen, Xiaoying; Wesley, Martina S; Eisel, Nathan; Yates, Nicole L; Zhang, Lu; Sawant, Sheetal; De Rosa, Stephen C; Cohen, Kristen W; Stanfield-Oakley, Sherry; Sholukh, Anton M; Germain, Russell St; Li, Xiaohong; Hu, Jiani; Premkumar, Lakshmanane; Gallardo-Cartagena, Jorge A; Randhawa, April Kaur; Dennison, S Moses; Hural, John A; Corey, Lawrence; Karuna, Shelly; McElrath, M Juliana; Ferrari, Guido; Hyrien, Ollivier; Tomaras, Georgia D

ALVAC-prime and monomeric gp120 protein boost induces distinct HIV-1 specific humoral and cellular responses compared with adenovirus-prime and trimeric gp140 protein boost

与腺病毒启动和三聚体gp140蛋白增强相比,ALVAC启动和单体gp120蛋白增强可诱导不同的HIV-1特异性体液和细胞免疫反应。

Fisher, Leigh H; Lazarus, Erica; Yu, Chenchen; Moodie, Zoe; Stieh, Daniel J; Yates, Nicole; Zhang, Lu; Sawant, Sheetal; De Rosa, Stephen C; Cohen, Kristen W; Morris, Daryl; Grant, Shannon; Randhawa, April; Miner, Maurine D; Hendriks, Jenny; Wegmann, Frank; Gill, Katherine M; Laher, Fatima; Bekker, Linda-Gail; Gray, Glenda E; Corey, Lawrence; McElrath, M Juliana; Martin, Troy; Gilbert, Peter B; Tomaras, Georgia; Walsh, Stephen R; Baden, Lindsey R

Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial

在一项 I 期临床试验中,接种 mRNA 编码的膜锚定 HIV 包膜三聚体疫苗可诱导产生 2 级中和抗体。

Parks, K Rachael; Moodie, Zoe; Allen, Mary A; Yen, Catherine; Furch, Briana D; MacPhee, Kellie J; Ozorowski, Gabriel; Heptinstall, Jack; Hahn, William O; Zheng, Zihan; Lu, Huiyin; Grant, Shannon; Domin, Elize; Duff, Michael O; Seese, Aaron; Marini-Macouzet, Constanza; Ballweber-Fleming, Lamar; Lee, Wen-Hsin; Cottrell, Christopher A; Liguori, Alessia; Georgeson, Erik; Alavi, Nushin; Kubitz, Michael; Phelps, Nicole; Seaton, Kelly E; Cohen, Kristen W; Anderson, Maija A; Mondal, Kajari; Laufer, Dagna S; Kublin, James G; Ward, Andrew B; Hyrien, Ollivier; De Rosa, Stephen C; Himansu, Sunny; Leav, Brett; Reuter, Caroline; Tomaras, Georgia D; Montefiori, David; Walsh, Stephen R; Frank, Ian; Sobieszczyk, Magdalena E; Goepfert, Paul A; Stephenson, Kathryn E; Baden, Lindsey R; Van Tieu, Hong; Keefer, Michael C; Clark, Jesse; Riddler, Sharon A; Schief, William R; McElrath, M Juliana

Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming

人类免疫球蛋白基因等位基因变异影响针对种系的疫苗初次免疫。

deCamp, Allan C; Corcoran, Martin M; Fulp, William J; Willis, Jordan R; Cottrell, Christopher A; Bader, Daniel L V; Kalyuzhniy, Oleksandr; Leggat, David J; Cohen, Kristen W; Hyrien, Ollivier; Menis, Sergey; Finak, Greg; Ballweber-Fleming, Lamar; Srikanth, Abhinaya; Plyler, Jason R; Rahaman, Farhad; Lombardo, Angela; Philiponis, Vincent; Whaley, Rachael E; Seese, Aaron; Brand, Joshua; Ruppel, Alexis M; Hoyland, Wesley; Mahoney, Celia R; Cagigi, Alberto; Taylor, Alison; Brown, David M; Ambrozak, David R; Sincomb, Troy; Mullen, Tina-Marie; Maenza, Janine; Kolokythas, Orpheus; Khati, Nadia; Bethony, Jeffrey; Roederer, Mario; Diemert, David; Koup, Richard A; Laufer, Dagna S; McElrath, Juliana M; McDermott, Adrian B; Karlsson Hedestam, Gunilla B; Schief, William R

A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses

首个针对人类生殖系的HIV纳米颗粒疫苗诱导了广泛且具有公共靶向性的辅助性T细胞反应。

Cohen, Kristen W; De Rosa, Stephen C; Fulp, William J; deCamp, Allan C; Fiore-Gartland, Andrew; Mahoney, Celia R; Furth, Sarah; Donahue, Josh; Whaley, Rachael E; Ballweber-Fleming, Lamar; Seese, Aaron; Schwedhelm, Katharine; Geraghty, Daniel; Finak, Greg; Menis, Sergey; Leggat, David J; Rahaman, Farhad; Lombardo, Angela; Borate, Bhavesh R; Philiponis, Vincent; Maenza, Janine; Diemert, David; Kolokythas, Orpheus; Khati, Nadia; Bethony, Jeffrey; Hyrien, Ollivier; Laufer, Dagna S; Koup, Richard A; McDermott, Adrian B; Schief, William R; McElrath, M Juliana

Trivalent mosaic or consensus HIV immunogens prime humoral and broader cellular immune responses in adults

三价嵌合体或共识型HIV免疫原可启动成人体内的体液免疫和更广泛的细胞免疫反应。

Cohen, Kristen W; Fiore-Gartland, Andrew; Walsh, Stephen R; Yusim, Karina; Frahm, Nicole; Elizaga, Marnie L; Maenza, Janine; Scott, Hyman; Mayer, Kenneth H; Goepfert, Paul A; Edupuganti, Srilatha; Pantaleo, Giuseppe; Hutter, Julia; Morris, Daryl E; De Rosa, Stephen C; Geraghty, Daniel E; Robb, Merlin L; Michael, Nelson L; Fischer, Will; Giorgi, Elena E; Malhi, Harman; Pensiero, Michael N; Ferrari, Guido; Tomaras, Georgia D; Montefiori, David C; Gilbert, Peter B; McElrath, M Juliana; Haynes, Barton F; Korber, Bette T; Baden, Lindsey R

Safety and Immunogenicity of Ad26-Vectored HIV Vaccine With Mosaic Immunogens and a Novel Mosaic Envelope Protein in HIV-Uninfected Adults: A Phase 1/2a Study

一项针对未感染 HIV 的成年人的 1/2a 期研究:以 Ad26 为载体、含有嵌合免疫原和新型嵌合包膜蛋白的 HIV 疫苗的安全性和免疫原性

Stieh, Daniel J; Barouch, Dan H; Comeaux, Christy; Sarnecki, Michal; Stephenson, Kathryn E; Walsh, Stephen R; Sawant, Sheetal; Heptinstall, Jack; Tomaras, Georgia D; Kublin, James G; McElrath, M Juliana; Cohen, Kristen W; De Rosa, Stephen C; Alter, Galit; Ferrari, Guido; Montefiori, David; Mann, Philipp; Nijs, Steven; Callewaert, Katleen; Goepfert, Paul A; Edupuganti, Srilatha; Karita, Etienne; Seaman, Michael S; Corey, Lawrence; Baden, Lindsey R; Pau, Maria G; Schuitemaker, Hanneke; Tomaka, Frank

Characterization of a vaccine-elicited human antibody with sequence homology to VRC01-class antibodies that binds the C1C2 gp120 domain

对一种疫苗诱导产生的、与VRC01类抗体具有序列同源性且能结合C1C2 gp120结构域的人类抗体进行表征

Gray, Matthew D; Feng, Junli; Weidle, Connor E; Cohen, Kristen W; Ballweber-Fleming, Lamar; MacCamy, Anna J; Huynh, Crystal N; Trichka, Josephine J; Montefiori, David; Ferrari, Guido; Pancera, Marie; McElrath, M Juliana; Stamatatos, Leonidas

Baseline host determinants of robust human HIV-1 vaccine-induced immune responses: A meta-analysis of 26 vaccine regimens

人类HIV-1疫苗诱导的强效免疫反应的基线宿主决定因素:26种疫苗方案的荟萃分析

Huang, Yunda; Zhang, Yuanyuan; Seaton, Kelly E; De Rosa, Stephen; Heptinstall, Jack; Carpp, Lindsay N; Randhawa, April Kaur; McKinnon, Lyle R; McLaren, Paul; Viegas, Edna; Gray, Glenda E; Churchyard, Gavin; Buchbinder, Susan P; Edupuganti, Srilatha; Bekker, Linda-Gail; Keefer, Michael C; Hosseinipour, Mina C; Goepfert, Paul A; Cohen, Kristen W; Williamson, Brian D; McElrath, M Juliana; Tomaras, Georgia D; Thakar, Juilee; Kobie, James J