Disruption of the centriolin/Cep110 gene (CNTRL) with CRISPR/Cas9 leads to cell cycle arrest and cell death of rhabdomyosarcoma cells in vitro.
利用 CRISPR/Cas9 技术破坏中心粒蛋白/Cep110 基因 (CNTRL) 可导致体外横纹肌肉瘤细胞的细胞周期停滞和细胞死亡。
期刊:Molecular Biology of the Cell
影响因子:2.7
doi:10.1091/mbc.E25-08-0365
Pfisterer Leonie, Boyle Caitlin, Cole Ariel, Mitchell Ilene, Flanagan Makaela, Gromley Zeynep, Gromley Adam