日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy.

对影响完全化学修饰的siRNA功效的siRNA和mRNA特征进行系统分析

Davis Sarah M, Hildebrand Samuel, MacMillan Hannah J, Monopoli Kathryn R, Buchwald Julianna, Sousa Jacquelyn, Cooper David, Ly Socheata, Echeverria Dimas, McHugh Nicholas, Ferguson Chantal, Coles Andrew, Hariharan Vignesh N, O'Reilly Daniel, Tang Qi, Furgal Raymond, Yamada Ken, Alterman Julia F, Gilbert James W, Knox Emily, Pineda Yamilett, Weston Caitlyn N, Baer Christina E, Pai Athma A, Khvorova Anastasia

siRNA tackles cancer: Immune checkpoint inhibitors and siRNA combinations

siRNA 对抗癌症:免疫检查点抑制剂与 siRNA 联合疗法

Coles, Andrew H

siRNA goes after diseases of the bone

siRNA用于治疗骨骼疾病

Coles, Andrew H

Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains

突变型亨廷顿蛋白信使RNA在啮齿动物和人类大脑中形成神经元核簇

Ly, Socheata; Didiot, Marie-Cécile; Ferguson, Chantal M; Coles, Andrew H; Miller, Rachael; Chase, Kathryn; Echeverria, Dimas; Wang, Feng; Sadri-Vakili, Ghazaleh; Aronin, Neil; Khvorova, Anastasia

Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep

利用治疗性siRNA进行的给药途径比较研究表明,多塞特绵羊体内存在广泛的基因调控。

Ferguson, Chantal M; Godinho, Bruno Mdc; Alterman, Julia F; Coles, Andrew H; Hassler, Matthew; Echeverria, Dimas; Gilbert, James W; Knox, Emily G; Caiazzi, Jillian; Haraszti, Reka A; King, Robert M; Taghian, Toloo; Puri, Ajit; Moser, Richard P; Gounis, Matthew J; Aronin, Neil; Gray-Edwards, Heather; Khvorova, Anastasia

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo.

用于体内功能性肝外siRNA递送的多种脂质缀合物

Biscans Annabelle, Coles Andrew, Haraszti Reka, Echeverria Dimas, Hassler Matthew, Osborn Maire, Khvorova Anastasia

The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo.

脂肪酸缀合物的价态会影响 siRNA 在体内的药代动力学、分布和疗效

Biscans Annabelle, Coles Andrew, Echeverria Dimas, Khvorova Anastasia

Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition

血清剥夺可改善间充质干细胞的外泌体活性并改变其脂质和蛋白质组成。

Haraszti, Reka Agnes; Miller, Rachael; Dubuke, Michelle L; Rockwell, Hannah E; Coles, Andrew H; Sapp, Ellen; Didiot, Marie-Cecile; Echeverria, Dimas; Stoppato, Matteo; Sere, Yves Y; Leszyk, John; Alterman, Julia F; Godinho, Bruno M D C; Hassler, Matthew R; McDaniel, Justice; Narain, Niven R; Wollacott, Rachel; Wang, Yang; Shaffer, Scott A; Kiebish, Michael A; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.

5α-乙烯基膦酸酯可提高结合型siRNA在体内的组织积累和疗效

Haraszti Reka A, Roux Loic, Coles Andrew H, Turanov Anton A, Alterman Julia F, Echeverria Dimas, Godinho Bruno M D C, Aronin Neil, Khvorova Anastasia

Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.

合成和评价代谢稳定的 O-磷酸胆碱-N-二十二碳六烯酰-L-丝氨酸 siRNA 缀合物在小鼠脑中的实质保留和功效

Nikan Mehran, Osborn Maire F, Coles Andrew H, Biscans Annabelle, Godinho Bruno M D C, Haraszti Reka A, Sapp Ellen, Echeverria Dimas, DiFiglia Marian, Aronin Neil, Khvorova Anastasia