日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

siRNA tackles cancer: Immune checkpoint inhibitors and siRNA combinations

siRNA 对抗癌症:免疫检查点抑制剂与 siRNA 联合疗法

Coles, Andrew H

siRNA goes after diseases of the bone

siRNA用于治疗骨骼疾病

Coles, Andrew H

Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains

突变型亨廷顿蛋白信使RNA在啮齿动物和人类大脑中形成神经元核簇

Ly, Socheata; Didiot, Marie-Cécile; Ferguson, Chantal M; Coles, Andrew H; Miller, Rachael; Chase, Kathryn; Echeverria, Dimas; Wang, Feng; Sadri-Vakili, Ghazaleh; Aronin, Neil; Khvorova, Anastasia

Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep

利用治疗性siRNA进行的给药途径比较研究表明,多塞特绵羊体内存在广泛的基因调控。

Ferguson, Chantal M; Godinho, Bruno Mdc; Alterman, Julia F; Coles, Andrew H; Hassler, Matthew; Echeverria, Dimas; Gilbert, James W; Knox, Emily G; Caiazzi, Jillian; Haraszti, Reka A; King, Robert M; Taghian, Toloo; Puri, Ajit; Moser, Richard P; Gounis, Matthew J; Aronin, Neil; Gray-Edwards, Heather; Khvorova, Anastasia

Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition

血清剥夺可改善间充质干细胞的外泌体活性并改变其脂质和蛋白质组成。

Haraszti, Reka Agnes; Miller, Rachael; Dubuke, Michelle L; Rockwell, Hannah E; Coles, Andrew H; Sapp, Ellen; Didiot, Marie-Cecile; Echeverria, Dimas; Stoppato, Matteo; Sere, Yves Y; Leszyk, John; Alterman, Julia F; Godinho, Bruno M D C; Hassler, Matthew R; McDaniel, Justice; Narain, Niven R; Wollacott, Rachel; Wang, Yang; Shaffer, Scott A; Kiebish, Michael A; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.

5α-乙烯基膦酸酯可提高结合型siRNA在体内的组织积累和疗效

Haraszti Reka A, Roux Loic, Coles Andrew H, Turanov Anton A, Alterman Julia F, Echeverria Dimas, Godinho Bruno M D C, Aronin Neil, Khvorova Anastasia

Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.

合成和评价代谢稳定的 O-磷酸胆碱-N-二十二碳六烯酰-L-丝氨酸 siRNA 缀合物在小鼠脑中的实质保留和功效

Nikan Mehran, Osborn Maire F, Coles Andrew H, Biscans Annabelle, Godinho Bruno M D C, Haraszti Reka A, Sapp Ellen, Echeverria Dimas, DiFiglia Marian, Aronin Neil, Khvorova Anastasia

Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain

二十二碳六烯酸偶联可增强siRNA在小鼠脑内局部给药后的分布和安全性

Nikan, Mehran; Osborn, Maire F; Coles, Andrew H; Godinho, Bruno Mdc; Hall, Lauren M; Haraszti, Reka A; Hassler, Matthew R; Echeverria, Dimas; Aronin, Neil; Khvorova, Anastasia

A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo

一种用于直接检测体内治疗性寡核苷酸诱导基因沉默的高通量方法

Coles, Andrew H; Osborn, Maire F; Alterman, Julia F; Turanov, Anton A; Godinho, Bruno M D C; Kennington, Lori; Chase, Kathryn; Aronin, Neil; Khvorova, Anastasia

Long-term survival for patients with acute decompensated heart failure according to ejection fraction findings

根据射血分数结果评估急性失代偿性心力衰竭患者的长期生存率

Coles, Andrew H; Fisher, Kimberly; Darling, Chad; Yarzebski, Jorge; McManus, David D; Gore, Joel M; Lessard, Darleen; Goldberg, Robert J