日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein

ADAM9 抑制可增加 ADAM10 的膜活性并控制淀粉样蛋白前体的 α-分泌酶加工

Marcia L Moss, Gary Powell, Miles A Miller, Lori Edwards, Bin Qi, Qing-Xiang Amy Sang, Bart De Strooper, Ina Tesseur, Stefan F Lichtenthaler, Mara Taverna, Julia Li Zhong, Colin Dingwall, Taheera Ferdous, Uwe Schlomann, Pei Zhou, Linda G Griffith, Douglas A Lauffenburger, Robert Petrovich, Jörg W Ba

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo

口服强效选择性非肽类 BACE-1 抑制剂可降低体内淀粉样蛋白前体的 β 裂解和淀粉样蛋白 β 的产生

Ishrut Hussain, Julie Hawkins, David Harrison, Christopher Hille, Gareth Wayne, Leanne Cutler, Tania Buck, Daryl Walter, Emmanuel Demont, Colin Howes, Alan Naylor, Philip Jeffrey, Maria I Gonzalez, Colin Dingwall, Anton Michel, Sally Redshaw, John B Davis