日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genomic screening reveals ubiquitin-like modifier activating enzyme 1 as a potent and druggable target in c-MYC-high triple negative breast cancer models

基因组筛查显示泛素样修饰激活酶 1 是 c-MYC 高三阴性乳腺癌模型中有效且可用药的靶点

Sheeba Jacob, Tia H Turner, Jinyang Cai, Konstantinos V Floros, Ann K Yu, Colin M Coon, Rishabh Khatri, Mohammad A Alzubi, Charles T Jakubik, Ynes M Bouck, Madhavi Puchalapalli, Mayuri Shende, Mikhail G Dozmorov, Sosipatros A Boikos, Bin Hu, J Chuck Harrell, Cyril H Benes, Jennifer E Koblinski, Carl

Pharmacologic Inhibition of SHP2 Blocks Both PI3K and MEK Signaling in Low-epiregulin HNSCC via GAB1

药物抑制 SHP2 可通过 GAB1 阻断低表皮调节素 HNSCC 中的 PI3K 和 MEK 信号传导

Richard Kurupi, Konstantinos V Floros, Sheeba Jacob, Ayesha T Chawla, Jinyang Cai, Bin Hu, Madhavi Puchalapalli, Colin M Coon, Rishabh Khatri, Giovanna Stein Crowther, Regina K Egan, Ellen Murchie, Patricia Greninger, Krista M Dalton, Maninderjit S Ghotra, Sosipatros A Boikos, Jennifer E Koblinski, 

MYCN-Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis

MYCN 扩增的神经母细胞瘤对铁有依赖性,且易受系统 Xc-/谷胱甘肽轴抑制的影响

Konstantinos V Floros #, JinYang Cai #, Sheeba Jacob #, Richard Kurupi, Carter K Fairchild, Mayuri Shende, Colin M Coon, Krista M Powell, Benjamin R Belvin, Bin Hu, Madhavi Puchalapalli, Sivapriya Ramamoorthy, Kimberly Swift, Janina P Lewis, Mikhail G Dozmorov, John Glod, Jennifer E Koblinski, Sosip

Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA

通过克服低 NOXA 揭示滑膜肉瘤中的 BCL-2 成瘾

Carter K Fairchild Jr, Konstantinos V Floros, Sheeba Jacob, Colin M Coon, Madhavi Puchalapalli, Bin Hu, Hisashi Harada, Mikhail G Dozmorov, Jennifer E Koblinski, Steven C Smith, Gregory Domson, Joel D Leverson, Andrew J Souers, Naoko Takebe, Hiromichi Ebi, Anthony C Faber, Sosipatros A Boikos

The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity

尤文家族肿瘤依赖 BCL-2 和 BCL-XL 逃避 PARP 抑制剂的毒性

Daniel A R Heisey, Timothy L Lochmann, Konstantinos V Floros, Colin M Coon, Krista M Powell, Sheeba Jacob, Marissa L Calbert, Maninderjit S Ghotra, Giovanna T Stein, Yuki Kato Maves, Steven C Smith, Cyril H Benes, Joel D Leverson, Andrew J Souers, Sosipatros A Boikos, Anthony C Faber