Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides
DNA 损伤修复酶聚(ADP-核糖)糖水解酶 (PARG) 的细胞活性小分子抑制剂:口服生物可利用的喹唑啉二酮磺酰胺的发现和优化
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.8b01407
Bohdan Waszkowycz, Kate M Smith, Alison E McGonagle, Allan M Jordan, Ben Acton, Emma E Fairweather, Louise A Griffiths, Niall M Hamilton, Nicola S Hamilton, James R Hitchin, Colin P Hutton, Dominic I James, Clifford D Jones, Stuart Jones, Daniel P Mould, Helen F Small, Alexandra I J Stowell, Julie A