Cartilage-specific Sirt6 deficiency represses IGF-1 and enhances osteoarthritis severity in mice
软骨特异性Sirt6缺陷会抑制IGF-1的表达,并加重小鼠骨关节炎的病情。
期刊:Annals of the Rheumatic Diseases
影响因子:20.6
doi:10.1136/ard-2023-224385
Collins, John A; Kim, C James; Coleman, Ashley; Little, Abreah; Perez, Matheus M; Clarke, Emily J; Diekman, Brian; Peffers, Mandy J; Chubinskaya, Susanna; Tomlinson, Ryan E; Freeman, Theresa A; Loeser, Richard F