KLF5 loss sensitizes cells to ATR inhibition and is synthetic lethal with ARID1A deficiency
KLF5 缺失会使细胞对 ATR 抑制剂更加敏感,并且与 ARID1A 缺陷具有合成致死性。
期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-024-55637-5
Samah W Awwad,Colm Doyle,Josie Coulthard,Aldo S Bader,Nadia Gueorguieva,Simon Lam,Vipul Gupta,Rimma Belotserkovskaya,Tuan-Anh Tran,Shankar Balasubramanian,Stephen P Jackson