日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Proteomic compensation by paralogs preserves protein interaction networks after gene loss in cancer

癌症中基因缺失后,旁系同源基因介导的蛋白质组补偿作用可维持蛋白质相互作用网络。

Anjan Venkatesh,Niall Quinn,Swathi Ramachandra Upadhya,Barbara De Kegel,Alfonso Bolado Carrancio,Thomas Lefeivre,Olivier Dennler,Kieran Wynne,Alexander von Kriegsheim,Colm J Ryan

Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells

跨物种鉴定 PIP5K1、剪接和泛素相关通路作为 RB1 缺陷细胞的潜在靶点

Andrey A Parkhitko, Arashdeep Singh, Sharon Hsieh, Yanhui Hu, Richard Binari, Christopher J Lord, Sridhar Hannenhalli, Colm J Ryan, Norbert Perrimon

Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions

对大规模功能缺失筛选结果的整合分析,揭示了与癌症密切相关的基因相互作用。

Christopher J Lord,Niall Quinn,Colm J Ryan

Accurate prediction of kinase-substrate networks using knowledge graphs

使用知识图谱准确预测激酶-底物网络

Vít Nováček, Gavin McGauran, David Matallanas, Adrián Vallejo Blanco, Piero Conca, Emir Muñoz, Luca Costabello, Kamalesh Kanakaraj, Zeeshan Nawaz, Brian Walsh, Sameh K Mohamed, Pierre-Yves Vandenbussche, Colm J Ryan, Walter Kolch, Dirk Fey

A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events

乳腺癌中共调节蛋白复合物的概要揭示了附带损失事件

Colm J Ryan, Susan Kennedy, Ilirjana Bajrami, David Matallanas, Christopher J Lord

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A

ATR 抑制剂作为 ARID1A 缺陷肿瘤的合成致死疗法

Chris T Williamson, Rowan Miller, Helen N Pemberton, Samuel E Jones, James Campbell, Asha Konde, Nicholas Badham, Rumana Rafiq, Rachel Brough, Aditi Gulati, Colm J Ryan, Jeff Francis, Peter B Vermulen, Andrew R Reynolds, Philip M Reaper, John R Pollard, Alan Ashworth, Christopher J Lord

Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines

癌细胞系中激酶依赖性的大规模分析

James Campbell, Colm J Ryan, Rachel Brough, Ilirjana Bajrami, Helen N Pemberton, Irene Y Chong, Sara Costa-Cabral, Jessica Frankum, Aditi Gulati, Harriet Holme, Rowan Miller, Sophie Postel-Vinay, Rumana Rafiq, Wenbin Wei, Chris T Williamson, David A Quigley, Joe Tym, Bissan Al-Lazikani, Timothy Fent