日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A critical role for plasma kallikrein in the pathogenesis of autoantibody-induced arthritis

血浆激肽释放酶在自身抗体诱导性关节炎发病机制中的关键作用

Yang, Aizhen; Zhou, Junsong; Wang, Bo; Dai, Jihong; Colman, Robert W; Song, Wenchao; Wu, Yi

Role of plasma kallikrein-kinin system activation in synovial recruitment of endothelial progenitor cells in experimental arthritis

血浆激肽释放酶-激肽系统激活在实验性关节炎滑膜内皮祖细胞募集中的作用

Dai, Jihong; Agelan, Alexis; Yang, Aizhen; Zuluaga, Viviana; Sexton, Daniel; Colman, Robert W; Wu, Yi

Cleaved high-molecular-weight kininogen accelerates the onset of endothelial progenitor cell senescence by induction of reactive oxygen species

裂解的高分子量激肽原通过诱导活性氧来加速内皮祖细胞衰老的发生。

Dai, Jihong; Zhu, Xuemei; Yoder, Mervin C; Wu, Yi; Colman, Robert W

Upregulation of tissue factor in monocytes by cleaved high molecular weight kininogen is dependent on TNF-alpha and IL-1beta

单核细胞中组织因子的上调是由裂解的高分子量激肽原介导的,该过程依赖于TNF-α和IL-1β。

Khan, Mohammad M; Liu, Yuchuan; Khan, Munir E; Gilman, Megan L; Khan, Sabina T; Bromberg, Michael; Colman, Robert W

A new nonhydrolyzable reactive cGMP analogue, (Rp)-guanosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate, which targets the cGMP binding site of human platelet PDE3A

一种新型不可水解的反应性cGMP类似物,(Rp)-鸟苷-3',5'-环-S-(4-溴-2,3-二氧丁基)单磷酸硫酯,靶向人血小板PDE3A的cGMP结合位点。

Hung, Su H; Liu, Andy H; Pixley, Robin A; Francis, Penelope; Williams, LaTeeka D; Matsko, Christopher M; Barnes, Karine D; Sivendran, Sharmila; Colman, Roberta F; Colman, Robert W

The inhibitory effect of HKa in endothelial cell tube formation is mediated by disrupting the uPA-uPAR complex and inhibiting its signaling and internalization

HKa对内皮细胞管状结构形成的抑制作用是通过破坏uPA-uPAR复合物并抑制其信号传导和内吞作用实现的。

Liu, Yuchuan; Cao, Dian J; Sainz, Irma M; Guo, Yan-Lin; Colman, Robert W

The inhibition of tube formation in a collagen-fibrinogen, three-dimensional gel by cleaved kininogen (HKa) and HK domain 5 (D5) is dependent on Src family kinases

裂解的激肽原 (HKa) 和 HK 结构域 5 (D5) 对胶原-纤维蛋白原三维凝胶中管状结构的抑制作用依赖于 Src 家族激酶。

Liu, Yuchuan; Sainz, Irma M; Wu, Yi; Pixley, Robin; Espinola, Ricardo G; Hassan, Sarmina; Khan, Mohammad M; Colman, Robert W

Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A

凝血酶通过磷酸二酯酶3A的磷酸化/激活来调节人血小板内环磷酸腺苷(cAMP)的浓度。

Zhang, Wei; Colman, Robert W

Are hemostasis and thrombosis two sides of the same coin?

止血和血栓形成是同一枚硬币的两面吗?

Colman, Robert W

High-molecular-weight kininogen fragments stimulate the secretion of cytokines and chemokines through uPAR, Mac-1, and gC1qR in monocytes.

高分子量激肽原片段通过 uPAR、Mac-1 和 gC1qR 刺激单核细胞分泌细胞因子和趋化因子

Khan Mohammad M, Bradford Harlan N, Isordia-Salas Irma, Liu Yuchuan, Wu Yi, Espinola Ricardo G, Ghebrehiwet Berhane, Colman Robert W