日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ceramide-induced Endoplasmic Reticulum Stress as a Targetable Vulnerability in Endocrine Therapy-Resistant Breast Cancer.

神经酰胺诱导的内质网应激是内分泌治疗耐药性乳腺癌的一个可靶向脆弱性

Pal Purab, Chitkara Shweta, Sarpey Godwin K, Alani Fatimah, Zhao Huiping, Ata Malik, Qu Jun, Schiff Rachel, Tonetti Debra, Greene Geoffrey L, Frasor Jonna, Atilla-Gokcumen Gunes Ekin, Coloff Jonathan L

Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis.

微环境中的精氨酸限制通过抑制脂质合成,使胰腺癌对多不饱和脂肪酸更加敏感

Jonker Patrick B, Sadullozoda Mumina, Cognet Guillaume, Saab Juan J Apiz, Sokol Kelly H, Wu Violet X, Kumari Deepa, Sheehan Colin, Ozgurses Mete E, Agovino Darby, Croley Grace, Patel Smit A, Bock-Hughes Althea, Macleod Kay F, Shah Hardik, Coloff Jonathan L, Lien Evan C, Muir Alexander

ASCT2 is a major contributor to serine uptake in cancer cells

ASCT2 是癌细胞吸收丝氨酸的主要因素

Kelly O Conger, Christopher Chidley, Mete Emir Ozgurses, Huiping Zhao, Yumi Kim, Svetlana E Semina, Philippa Burns, Vipin Rawat, Lina Lietuvninkas, Ryan Sheldon, Issam Ben-Sahra, Jonna Frasor, Peter K Sorger, Gina M DeNicola, Jonathan L Coloff

Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy

在人体生理介质中进行的药物筛选发现,尿酸是rigosertib疗效的抑制剂。

Rawat, Vipin; DeLear, Patrick; Prashanth, Prarthana; Ozgurses, Mete Emir; Tebeje, Anteneh; Burns, Philippa A; Conger, Kelly O; Solís, Christopher; Hasnain, Yasir; Novikova, Anna; Endress, Jennifer E; González-Sánchez, Paloma; Dong, Wentao; Stephanopoulos, Greg; DeNicola, Gina M; Harris, Isaac S; Sept, David; Mason, Frank M; Coloff, Jonathan L

ASCT2 is the primary serine transporter in cancer cells

ASCT2 是癌细胞中的主要丝氨酸转运蛋白

Kelly O Conger, Christopher Chidley, Mete Emir Ozgurses, Huiping Zhao, Yumi Kim, Svetlana E Semina, Philippa Burns, Vipin Rawat, Ryan Sheldon, Issam Ben-Sahra, Jonna Frasor, Peter K Sorger, Gina M DeNicola, Jonathan L Coloff

Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors

PSAT1 的谱系特异性沉默会导致管腔型乳腺肿瘤出现丝氨酸营养缺陷和对膳食丝氨酸饥饿的敏感性。

Bo-Hyun Choi ,Vipin Rawat ,Jenny Högström ,Philippa A Burns ,Kelly O Conger ,Mete Emir Ozgurses ,Jaymin M Patel ,Tejas S Mehta ,Angelica Warren ,Laura M Selfors ,Taru Muranen ,Jonathan L Coloff

SOX2 mediates metabolic reprogramming of prostate cancer cells

SOX2 介导前列腺癌细胞的代谢重编程

Larischa de Wet, Anthony Williams, Marc Gillard, Steven Kregel, Sophia Lamperis, Lisa C Gutgesell, Jordan E Vellky, Ryan Brown, Kelly Conger, Gladell P Paner, Heng Wang, Elizabeth A Platz, Angelo M De Marzo, Ping Mu, Jonathan L Coloff, Russell Z Szmulewitz, Donald J Vander Griend

Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells

EGF 和致癌 KRAS 刺激的人类乳腺上皮细胞中的差异底物使用

Mark A Keibler, Wentao Dong, Keegan D Korthauer, Aaron M Hosios, Sun Jin Moon, Lucas B Sullivan, Nian Liu, Keene L Abbott, Orlando D Arevalo, Kailing Ho, Jennifer Lee, Aasavari S Phanse, Joanne K Kelleher, Othon Iliopoulos, Jonathan L Coloff, Matthew G Vander Heiden, Gregory Stephanopoulos

PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

PHGDH 支持肝脏神经酰胺合成并维持脂质稳态

Yun Pyo Kang, Aimee Falzone, Min Liu, Paloma González-Sánchez, Bo-Hyun Choi, Jonathan L Coloff, James J Saller, Florian A Karreth, Gina M DeNicola

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

去泛素化酶在谷胱甘肽耗竭后维持蛋白质稳态和癌细胞存活

Isaac S Harris, Jennifer E Endress, Jonathan L Coloff, Laura M Selfors, Samuel K McBrayer, Jennifer M Rosenbluth, Nobuaki Takahashi, Sabin Dhakal, Vidyasagar Koduri, Matthew G Oser, Nathan J Schauer, Laura M Doherty, Andrew L Hong, Yun Pyo Kang, Scott T Younger, John G Doench, William C Hahn, Sara J