日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure

体外和脑暴露中具有抗寄生虫效力的弓形虫苯丙氨酸tRNA合成酶双环吡咯烷抑制剂

Ence, Chloe C; Uddin, Taher; Borrel, Julien; Mittal, Payal; Xie, Han; Zoller, Jochen; Sharma, Amit; Comer, Eamon; Schreiber, Stuart L; Melillo, Bruno; Sibley, L David; Chatterjee, Arnab K

Bicyclic pyrrolidine inhibitors of Toxoplasma gondii phenylalanine t-RNA synthetase with antiparasitic potency in vitro and brain exposure

体外和脑暴露实验表明,双环吡咯烷类弓形虫苯丙氨酸tRNA合成酶抑制剂具有抗寄生虫活性。

Ence, Chloe C; Uddin, Taher; Borrel, Julien; Mittal, Payal; Xie, Han; Zoller, Jochen; Sharma, Amit; Comer, Eamon; Schreiber, Stuart L; Melillo, Bruno; Sibley, L David; Chatterjee, Arnab K

Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase

双环氮杂环丁烷类化合物通过抑制寄生虫苯丙氨酰-tRNA合成酶,杀死小鼠体内引起腹泻的病原体隐孢子虫。

Vinayak, Sumiti; Jumani, Rajiv S; Miller, Peter; Hasan, Muhammad M; McLeod, Briana I; Tandel, Jayesh; Stebbins, Erin E; Teixeira, Jose E; Borrel, Julien; Gonse, Arthur; Zhang, Mingliang; Yu, Xianshui; Wernimont, Amy; Walpole, Chris; Eckley, Sean; Love, Melissa S; McNamara, Case W; Sharma, Manmohan; Sharma, Amit; Scherer, Christina A; Kato, Nobutaka; Schreiber, Stuart L; Melillo, Bruno; Striepen, Boris; Huston, Christopher D; Comer, Eamon

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

多样性导向合成产生新型多阶段抗疟疾抑制剂

Kato Nobutaka, Comer Eamon, Sakata-Kato Tomoyo, Sharma Arvind, Sharma Manmohan, Maetani Micah, Bastien Jessica, Brancucci Nicolas M, Bittker Joshua A, Corey Victoria, Clarke David, Derbyshire Emily R, Dornan Gillian L, Duffy Sandra, Eckley Sean, Itoe Maurice A, Koolen Karin M J, Lewis Timothy A, Lui Ping S, Lukens Amanda K, Lund Emily, March Sandra, Meibalan Elamaran, Meier Bennett C, McPhail Jacob A, Mitasev Branko, Moss Eli L, Sayes Morgane, Van Gessel Yvonne, Wawer Mathias J, Yoshinaga Takashi, Zeeman Anne-Marie, Avery Vicky M, Bhatia Sangeeta N, Burke John E, Catteruccia Flaminia, Clardy Jon C, Clemons Paul A, Dechering Koen J, Duvall Jeremy R, Foley Michael A, Gusovsky Fabian, Kocken Clemens H M, Marti Matthias, Morningstar Marshall L, Munoz Benito, Neafsey Daniel E, Sharma Amit, Winzeler Elizabeth A, Wirth Dyann F, Scherer Christina A, Schreiber Stuart L

High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission

利用高通量检测方法发现能够阻断疟疾传播的小分子

Plouffe, David M; Wree, Melanie; Du, Alan Y; Meister, Stephan; Li, Fengwu; Patra, Kailash; Lubar, Aristea; Okitsu, Shinji L; Flannery, Erika L; Kato, Nobutaka; Tanaseichuk, Olga; Comer, Eamon; Zhou, Bin; Kuhen, Kelli; Zhou, Yingyao; Leroy, Didier; Schreiber, Stuart L; Scherer, Christina A; Vinetz, Joseph; Winzeler, Elizabeth A

Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity

利用新型无菌培养法开发和验证一种新型利什曼原虫高通量筛选级联方法,该方法对利什曼原虫杀灭细胞内活性具有高预测性。

Nühs, Andrea; De Rycker, Manu; Manthri, Sujatha; Comer, Eamon; Scherer, Christina A; Schreiber, Stuart L; Ioset, Jean-Robert; Gray, David W

Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents

以多样性为导向的合成促进药物化学:迈向新型抗疟药物的开发

Comer, Eamon; Beaudoin, Jennifer A; Kato, Nobutaka; Fitzgerald, Mark E; Heidebrecht, Richard W; Lee, Maurice duPont 4th; Masi, Daniela; Mercier, Marion; Mulrooney, Carol; Muncipinto, Giovanni; Rowley, Ann; Crespo-Llado, Keila; Serrano, Adelfa E; Lukens, Amanda K; Wiegand, Roger C; Wirth, Dyann F; Palmer, Michelle A; Foley, Michael A; Munoz, Benito; Scherer, Christina A; Duvall, Jeremy R; Schreiber, Stuart L