日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

HDX-MS study on garadacimab binding to activated FXII reveals potential binding interfaces through differential solvent exposure

HDX-MS 研究加拉昔单抗与活化 FXII 的结合,通过差异溶剂暴露揭示潜在的结合界面

Saw Yen Ow, Eugene A Kapp, Vesna Tomasetig, Anton Zalewski, Jason Simmonds, Con Panousis, Michael J Wilson, Andrew D Nash, Matthias Pelzing

Evaluation of Phage Display Biopanning Strategies for the Selection of Anti-Cell Surface Receptor Antibodies

噬菌体展示生物淘选策略在抗细胞表面受体抗体筛选中的评估

Nadya Panagides, Lucia F Zacchi, Mitchell J De Souza, Rodrigo A V Morales, Alexander Karnowski, Mark T Liddament, Catherine M Owczarek, Stephen M Mahler, Con Panousis, Martina L Jones, Christian Fercher

Generation of a humanized FXII knock-in mouse-A powerful model system to test novel anti-thrombotic agents

人源化 FXII 基因敲入小鼠的产生——一种测试新型抗血栓药物的强大模型系统

Sarah Beck, David Stegner, Stefan Loroch, Ayesha A Baig, Vanessa Göb, Cornelia Schumbrutzki, Eva Eilers, Albert Sickmann, Frauke May, Marc W Nolte, Con Panousis, Bernhard Nieswandt

Increased potency of recombinant VWF D'D3 albumin fusion proteins engineered for enhanced affinity for coagulation factor VIII

重组 VWF D'D3 白蛋白融合蛋白的效力增强,旨在增强对凝血因子 VIII 的亲和力

Jenny Chia, Sabine Pestel, Isabelle Glauser, Kerstin Emmrich, Matthew P Hardy, Marcel Mischnik, Elmar Raquet, Vesna Tomasetig, Philipp Claar, Anton Zalewski, Gregory T Bass, Victor Turnbull, Chao-Guang Chen, Michael J Wilson, Con Panousis, Thomas Weimer, Arna Andrews, Anne M Verhagen, Steve K Dower

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells

血液凝固因子XII通过CD87介导的树突状细胞调节,驱动神经炎症期间的适应性免疫。

Kerstin Göbel ,Susann Pankratz ,Chloi-Magdalini Asaridou ,Alexander M Herrmann ,Stefan Bittner ,Monika Merker ,Tobias Ruck ,Sarah Glumm ,Friederike Langhauser ,Peter Kraft ,Thorsten F Krug ,Johanna Breuer ,Martin Herold ,Catharina C Gross ,Denise Beckmann ,Adelheid Korb-Pap ,Michael K Schuhmann ,Stefanie Kuerten ,Ioannis Mitroulis ,Clemens Ruppert ,Marc W Nolte ,Con Panousis ,Luisa Klotz ,Beate Kehrel ,Thomas Korn ,Harald F Langer ,Thomas Pap ,Bernhard Nieswandt ,Heinz Wiendl ,Triantafyllos Chavakis ,Christoph Kleinschnitz ,Sven G Meuth

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors

CSL311 是一种新型、强效的治疗性单克隆抗体,用于治疗由 IL-3、GM-CSF 和 IL-5 受体的共同 β 链介导的疾病。

Con Panousis ,Urmi Dhagat ,Kirsten M Edwards ,Veronika Rayzman ,Matthew P Hardy ,Hal Braley ,Gail M Gauvreau ,Timothy R Hercus ,Steven Smith ,Roma Sehmi ,Laura McMillan ,Mara Dottore ,Barbara J McClure ,Louis J Fabri ,Gino Vairo ,Angel F Lopez ,Michael W Parker ,Andrew D Nash ,Nicholas J Wilson ,Michael J Wilson ,Catherine M Owczarek

Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis

G-CSF 受体的治疗靶向作用可减少抗体介导的炎症性关节炎中的中性粒细胞运输和关节炎症

Ian K Campbell, David Leong, Kirsten M Edwards, Veronika Rayzman, Milica Ng, Gabrielle L Goldberg, Nicholas J Wilson, Karen Scalzo-Inguanti, Charley Mackenzie-Kludas, Kate E Lawlor, Ian P Wicks, Lorena E Brown, Adriana Baz Morelli, Con Panousis, Michael J Wilson, Andrew D Nash, Brent S McKenzie, Arn

Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III

凝血因子 XII 糖基化缺陷是遗传性血管性水肿 III 型的根本原因

Jenny Björkqvist, Steven de Maat, Urs Lewandrowski, Antonio Di Gennaro, Chris Oschatz, Kai Schönig, Markus M Nöthen, Christian Drouet, Hal Braley, Marc W Nolte, Albert Sickmann, Con Panousis, Coen Maas, Thomas Renné

One-step zero-background IgG reformatting of phage-displayed antibody fragments enabling rapid and high-throughput lead identification

噬菌体展示抗体片段的一步零背景 IgG 重组可实现快速、高通量的先导化合物识别

Chao-Guang Chen, Louis J Fabri, Michael J Wilson, Con Panousis