β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity.
β-淀粉样蛋白诱导小胶质细胞表达GPC4和APOE,导致神经元tau蛋白病理和毒性增加
期刊:Molecular Neurodegeneration
影响因子:17.5
doi:10.1186/s13024-025-00883-4
Holmes Brandon B, Weigel Thaddeus K, Chung Jesseca M, Kaufman Sarah K, Apresa Brandon I, Byrnes James R, Kumru Kaan S, Vaquer-Alicea Jaime, Gupta Ankit, Rose Indigo V L, Zhang Yun, Nana Alissa L, Alter Dina, Grinberg Lea T, Spina Salvatore, Leung Kevin K, Miller Bruce L, Condello Carlo, Kampmann Martin, Seeley William W, Coutinho-Budd Jaeda C, Wells James A