日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs.

利用高通量方法发现可识别淀粉样蛋白原纤维多晶型的荧光探针。

Carroll Emma C, Yang Hyunjun, Powell Wyatt C, Charvat Annemarie F, Oehler Abby, Jones Julia G, Montgomery Kelly M, Yung Anthony, Millbern Zoe, Taylor Alexander I P, Wilkinson Martin, Ranson Neil A, Radford Sheena E, Vinueza Nelson R, DeGrado William F, Mordes Daniel A, Condello Carlo, Gestwicki Jason E

β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity.

β-淀粉样蛋白诱导小胶质细胞表达GPC4和APOE,导致神经元tau蛋白病理和毒性增加

Holmes Brandon B, Weigel Thaddeus K, Chung Jesseca M, Kaufman Sarah K, Apresa Brandon I, Byrnes James R, Kumru Kaan S, Vaquer-Alicea Jaime, Gupta Ankit, Rose Indigo V L, Zhang Yun, Nana Alissa L, Alter Dina, Grinberg Lea T, Spina Salvatore, Leung Kevin K, Miller Bruce L, Condello Carlo, Kampmann Martin, Seeley William W, Coutinho-Budd Jaeda C, Wells James A

β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity.

β-淀粉样蛋白诱导小胶质细胞表达GPC4和APOE,导致神经元Tau病理和毒性增加

Holmes Brandon B, Weigel Thaddeus K, Chung Jesseca M, Kaufman Sarah K, Apresa Brandon I, Byrnes James R, Kumru Kaan S, Vaquer-Alicea Jaime, Gupta Ankit, Rose Indigo V L, Zhang Yun, Nana Alissa L, Alter Dina, Grinberg Lea T, Spina Salvatore, Leung Kevin K, Condello Carlo, Kampmann Martin, Seeley William W, Coutinho-Budd Jaeda C, Wells James A

De novo design of peptides that bind specific conformers of α-synuclein

从头设计与α-突触核蛋白特定构象结合的肽。

Wallace, Hailey M; Yang, Hyunjun; Tan, Sophia; Pan, Henry S; Yang, Rose; Xu, Junyi; Jo, Hyunil; Condello, Carlo; Polizzi, Nicholas F; DeGrado, William F

Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold

冷冻电镜结构揭示唐氏综合征患者的tau蛋白丝会折叠成阿尔茨海默病患者的折叠结构。

Ghosh, Ujjayini; Tse, Eric; Yang, Hyunjun; Shi, Marie; Carlo, Christoffer D; Wang, Feng; Merz, Gregory E; Prusiner, Stanley B; Southworth, Daniel R; Condello, Carlo

EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains

EMBER多维光谱显微镜能够定量测定疾病和细胞特异性淀粉样蛋白菌株

Yang, Hyunjun; Yuan, Peng; Wu, Yibing; Shi, Marie; Caro, Christoffer D; Tengeiji, Atsushi; Yamanoi, Shigeo; Inoue, Masahiro; DeGrado, William F; Condello, Carlo

Total Chemical Synthesis of Glycosylated TREM2 Ectodomain

糖基化TREM2胞外结构域的全化学合成

Wijegunawardena, Gayani; Castillo, Erika; Henrickson, Brandy; Davis, Regan; Condello, Carlo; Wu, Haifan

Amyloid β Proteoforms Elucidated by Quantitative LC/MS in the 5xFAD Mouse Model of Alzheimer's Disease

利用定量液相色谱-质谱联用技术阐明5xFAD阿尔茨海默病小鼠模型中的β淀粉样蛋白异构体

Kandi, Soumya; Cline, Erika N; Rivera, Brianna M; Viola, Kirsten L; Zhu, Jiuhe; Condello, Carlo; LeDuc, Richard D; Klein, William L; Kelleher, Neil L; Patrie, Steven M

Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ

可溶性TREM2抑制Aβ纤维化的二次成核,并增强细胞对纤维状Aβ的摄取

Belsare, Ketaki D; Wu, Haifan; Mondal, Dibyendu; Bond, Annalise; Castillo, Erika; Jin, Jia; Jo, Hyunil; Roush, Addison E; Pilla, Kala Bharath; Sali, Andrej; Condello, Carlo; DeGrado, William F

Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging

小胶质细胞介导的神经保护、TREM2 和阿尔茨海默病:来自光学成像的证据

Condello, Carlo; Yuan, Peng; Grutzendler, Jaime