日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Monitoring biological effects of somatic cell genome editing

监测体细胞基因组编辑的生物学效应

Freedman, Benjamin S; Bulte, Jeff W M; Conklin, Bruce R; Judge, Luke M; Dwinell, Melinda R; Geurts, Aron M; Sitton, Madeleine J; Mahajan, Vineet; Kiani, Samira; Gersbach, Charles A; Ebrahimkhani, Mo R; Kelly, John J; Ronald, John A; Morizane, Ryuji; Gupta, Navin; Shakeri-Zadeh, Ali; Vo, Nicole; Saha, Krishanu; Saxena, Shivani; Gamm, David M; Sinha, Divya; Tarantal, Alice F; Vandsburger, Moriel; Matsubara, Azusa; Fu, Hongxia; Tsai, Shengdar Q

Haplotype editing with CRISPR-Cas9 as a therapeutic approach for dominant-negative missense mutations in NEFL

利用 CRISPR-Cas9 进行单倍型编辑作为治疗 NEFL 中显性负性错义突变的治疗方法

Dua, Poorvi H; Simon, Bazilco M J; Marley, Chiara B E; Feliciano, Carissa M; Watry, Hannah L; Cowan, Quinn T; Steury, Dylan; Abraham, Abin; Gilbertson, Erin N; Ramey, Grace D; Capra, John A; Conklin, Bruce R; Judge, Luke M

Using image classifiers to predict CMT2A disease-relevant mitochondrial motility phenotypes in iPSC motor neurons

利用图像分类器预测iPSC运动神经元中与CMT2A疾病相关的线粒体运动表型

Epstein, Leo; Weiner, Adam C; Macklin, Bria L; Kelly, Kaitlin R; Conklin, Bruce R; Engelhardt, Barbara E

Leveraging human genetic variation to therapeutically target hundreds of genes with dominant & dispensable disease alleles

利用人类遗传变异,以治疗为目标,靶向数百个具有显性和非显性致病等位基因的基因。

Ramey, Grace D; Cowan, Quinn T; Saxena, Akshita G; Macklin, Bria L; Watry, Hannah L; Mei, Xiaoyue; Dierks, Philip; Judge, Luke M; Conklin, Bruce R; Capra, John A

Functional analysis of a common BAG3 allele associated with protection from heart failure.

对与预防心力衰竭相关的常见 BAG3 等位基因进行功能分析

Perez-Bermejo Juan A, Judge Luke M, Jensen Christina L, Wu Kenneth, Watry Hannah L, Truong Annie, Ho Jaclyn J, Carter Matthew, Runyon Wendy V, Kaake Robyn M, Pulido Ernst H, Mandegar Mohammad A, Swaney Danielle L, So Po-Lin, Krogan Nevan J, Conklin Bruce R

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq

利用 DISCOVER-Seq 技术在体内进行无偏 CRISPR 脱靶效应检测

Wienert, Beeke; Wyman, Stacia K; Richardson, Christopher D; Yeh, Charles D; Akcakaya, Pinar; Porritt, Michelle J; Morlock, Michaela; Vu, Jonathan T; Kazane, Katelynn R; Watry, Hannah L; Judge, Luke M; Conklin, Bruce R; Maresca, Marcello; Corn, Jacob E

AlleleAnalyzer: a tool for personalized and allele-specific sgRNA design

AlleleAnalyzer:一种用于个性化和等位基因特异性sgRNA设计的工具

Keough, Kathleen C; Lyalina, Svetlana; Olvera, Michael P; Whalen, Sean; Conklin, Bruce R; Pollard, Katherine S

Quantitatively characterizing drug-induced arrhythmic contractile motions of human stem cell-derived cardiomyocytes

定量表征药物诱导的人类干细胞衍生心肌细胞心律失常收缩运动

Hoang, Plansky; Huebsch, Nathaniel; Bang, Shin Hyuk; Siemons, Brian A; Conklin, Bruce R; Healy, Kevin E; Ma, Zhen; Jacquir, Sabir

Detection and Quantification of HDR and NHEJ Induced by Genome Editing at Endogenous Gene Loci Using Droplet Digital PCR

利用液滴数字PCR检测和定量内源基因位点基因组编辑诱导的HDR和NHEJ

Miyaoka, Yuichiro; Mayerl, Steven J; Chan, Amanda H; Conklin, Bruce R

Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes

用于检测微图案化人诱导多能干细胞衍生心肌细胞收缩机械输出的多成像方法

Ribeiro, Alexandre J S; Schwab, Olivier; Mandegar, Mohammad A; Ang, Yen-Sin; Conklin, Bruce R; Srivastava, Deepak; Pruitt, Beth L