日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A binding site for the antibiotic GE81112 in the ribosomal mRNA channel

核糖体mRNA通道中抗生素GE81112的结合位点

Schedlbauer, Andreas; Han, Xu; van Bakel, Wouter; Kaminishi, Tatsuya; Ochoa-Lizarralde, Borja; Iturrioz, Idoia; Çapuni, Retina; Parry, Ransford; Zegarra, Ronny; Gil-Carton, David; López-Alonso, Jorge P; Barragan Sanz, Kristina; Brandi, Letizia; Gualerzi, Claudio O; Fucini, Paola; Connell, Sean R

CryoEM reveals that ribosomes in microsporidian spores are locked in a dimeric hibernating state

冷冻电镜显示,微孢子虫孢子中的核糖体处于二聚体休眠状态。

McLaren, Mathew; Conners, Rebecca; Isupov, Michail N; Gil-Díez, Patricia; Gambelli, Lavinia; Gold, Vicki A M; Walter, Andreas; Connell, Sean R; Williams, Bryony; Daum, Bertram

Disruption of Dcp1 leads to a Dcp2-dependent aberrant ribosome profiles in Aspergillus nidulans.

Dcp1 的破坏导致构巢曲霉中出现 Dcp2 依赖的异常核糖体谱

Bharudin Izwan, Caddick Mark X, Connell Sean R, Lamaudière Matthew T F, Morozov Igor Y

Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods

利用结构和计算方法评估严重急性呼吸综合征冠状病毒2刺突蛋白聚糖的流动性

Stagnoli, Soledad; Peccati, Francesca; Connell, Sean R; Martinez-Castillo, Ane; Charro, Diego; Millet, Oscar; Bruzzone, Chiara; Palazon, Asis; Ardá, Ana; Jiménez-Barbero, Jesús; Ereño-Orbea, June; Abrescia, Nicola G A; Jiménez-Osés, Gonzalo

Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding.

GE81112 对翻译起始复合物形成的抑制作用揭示了参与 P 位点解码的 16S rRNA 结构开关

Fabbretti Attilio, Schedlbauer Andreas, Brandi Letizia, Kaminishi Tatsuya, Giuliodori Anna Maria, Garofalo Raffaella, Ochoa-Lizarralde Borja, Takemoto Chie, Yokoyama Shigeyuki, Connell Sean R, Gualerzi Claudio O, Fucini Paola

Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.

潮霉素A核糖体结合位点的晶体学表征及分子作用机制

Kaminishi Tatsuya, Schedlbauer Andreas, Fabbretti Attilio, Brandi Letizia, Ochoa-Lizarralde Borja, He Cheng-Guang, Milón Pohl, Connell Sean R, Gualerzi Claudio O, Fucini Paola

Structural characterization of an alternative mode of tigecycline binding to the bacterial ribosome

替加环素与细菌核糖体结合的另一种模式的结构表征

Schedlbauer, Andreas; Kaminishi, Tatsuya; Ochoa-Lizarralde, Borja; Dhimole, Neha; Zhou, Shu; López-Alonso, Jorge P; Connell, Sean R; Fucini, Paola

GTPase activation of elongation factor EF-Tu by the ribosome during decoding

解码过程中,核糖体通过GTP酶激活延伸因子EF-Tu。

Schuette, Jan-Christian; Murphy, Frank V 4th; Kelley, Ann C; Weir, John R; Giesebrecht, Jan; Connell, Sean R; Loerke, Justus; Mielke, Thorsten; Zhang, Wei; Penczek, Pawel A; Ramakrishnan, V; Spahn, Christian M T

The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning.

恶唑烷酮类抗生素会扰乱核糖体肽基转移酶中心,并影响 tRNA 的定位

Wilson Daniel N, Schluenzen Frank, Harms Joerg M, Starosta Agata L, Connell Sean R, Fucini Paola

A dedicated translation factor controls the synthesis of the global regulator Fis

一个专门的翻译因子控制着全局调节因子 Fis 的合成。

Owens, Róisín M; Pritchard, Gareth; Skipp, Paul; Hodey, Michelle; Connell, Sean R; Nierhaus, Knud H; David O'Connor, C