日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeted protein degradation via intramolecular bivalent glues

通过分子内二价胶实现靶向蛋白质降解

Oliver Hsia # ,Matthias Hinterndorfer # ,Angus D Cowan # ,Kentaro Iso ,Tasuku Ishida ,Ramasubramanian Sundaramoorthy ,Mark A Nakasone ,Hana Imrichova ,Caroline Schätz ,Andrea Rukavina ,Koraljka Husnjak ,Martin Wegner ,Alejandro Correa-Sáez ,Conner Craigon ,Ryan Casement ,Chiara Maniaci ,Andrea Testa ,Manuel Kaulich ,Ivan Dikic ,Georg E Winter ,Alessio Ciulli

Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera

利用双连接酶募集通过异三价蛋白水解靶向嵌合体增强蛋白质降解

Adam G Bond, Miquel Muñoz I Ordoño, Celia M Bisbach, Conner Craigon, Nikolai Makukhin, Elizabeth A Caine, Manjula Nagala, Marjeta Urh, Georg E Winter, Kristin M Riching, Alessio Ciulli

Mechanism of degrader-targeted protein ubiquitinability

降解剂靶向蛋白质泛素化的机制

Charlotte Crowe, Mark A Nakasone, Sarah Chandler, Conner Craigon, Gajanan Sathe, Michael H Tatham, Nikolai Makukhin, Ronald T Hay, Alessio Ciulli

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

三价 PROTAC 通过结合亲和力和协同作用增强蛋白质降解

Satomi Imaide #, Kristin M Riching #, Nikolai Makukhin #, Vesna Vetma, Claire Whitworth, Scott J Hughes, Nicole Trainor, Sarah D Mahan, Nancy Murphy, Angus D Cowan, Kwok-Ho Chan, Conner Craigon, Andrea Testa, Chiara Maniaci, Marjeta Urh, Danette L Daniels, Alessio Ciulli

Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity

酰胺-酯取代作为优化 PROTAC 通透性和细胞活性的策略

Victoria G Klein, Adam G Bond, Conner Craigon, R Scott Lokey, Alessio Ciulli

Development of BromoTag: A "Bump-and-Hole"-PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins

BromoTag 的开发:“Bump-and-Hole”-PROTAC 系统可诱导标记靶蛋白的强效、快速和选择性降解

Adam G Bond, Conner Craigon, Kwok-Ho Chan, Andrea Testa, Athanasios Karapetsas, Rotimi Fasimoye, Thomas Macartney, J Julian Blow, Dario R Alessi, Alessio Ciulli