日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Autologous HIV-specific T cell therapy targeting conserved epitopes is well-tolerated in six adults with HIV: an open-label, single-arm phase 1 study

一项开放标签、单臂1期研究显示,针对保守表位的自体HIV特异性T细胞疗法在6名HIV感染成人患者中耐受性良好。

Danielle K Sohai ,Michael D Keller ,Patrick J Hanley ,Fahmida Hoq ,Divyesh Kukadiya ,Anushree Datar ,Emily Reynolds ,Dennis C Copertino ,Christopher Lazarski ,Chase D McCann ,Jay Tanna ,Abeer Shibli ,Haili Lang ,Anqing Zhang ,Pamela A Chansky ,Cecilia Motta ,Tan T Huynh ,Bridget Dwyer ,Andrew Wilson ,Rebecca Lynch ,Talia M Mota ,Winiffer D Conce Alberto ,Zabrina L Brumme ,Natalie N Kinloch ,Conrad Russell Y Cruz ,Lynsay MacLaren Ehui ,Sarah Henn ,R Brad Jones ,Catherine M Bollard

Photothermal Prussian blue nanoparticles generate potent multi-targeted tumor-specific T cells as an adoptive cell therapy

光热普鲁士蓝纳米颗粒可生成强效的多靶点肿瘤特异性T细胞,作为一种过继细胞疗法。

Sweeney, Elizabeth E; Sekhri, Palak; Muniraj, Nethaji; Chen, Jie; Feng, Sally; Terao, Joshua; Chin, Samantha J; Schmidt, Danielle E; Bollard, Catherine M; Cruz, Conrad Russell Y; Fernandes, Rohan

Nanodepots Encapsulating a Latency Reversing Agent and Broadly Neutralizing Antibody Enhance Natural Killer Cell Cytotoxicity Against an in vitro Model of Latent HIV

封装潜伏期逆转剂和广谱中和抗体的纳米节点增强自然杀伤细胞对潜伏 HIV 体外模型的细胞毒性

Joshua Ghofrani, Allan Bowen, Jie Chen, Preethi Bala Balakrishnan, Allison B Powell, Kondareddy Cherukula, Conrad Russell Y Cruz, R Brad Jones, Rebecca M Lynch, Elizabeth E Sweeney, Rohan Fernandes

The generation and application of antigen-specific T cell therapies for cancer and viral-associated disease

抗原特异性T细胞疗法在癌症和病毒相关疾病中的产生和应用

Hont, Amy B; Powell, Allison B; Sohai, Danielle K; Valdez, Izabella K; Stanojevic, Maja; Geiger, Ashley E; Chaudhary, Kajal; Dowlati, Ehsan; Bollard, Catherine M; Cruz, Conrad Russell Y

A biomarker panel for risk of early respiratory failure following hematopoietic cell transplantation.

造血干细胞移植后早期呼吸衰竭风险的生物标志物组合

Rowan Courtney M, Smith Lincoln, Sharron Matthew P, Loftis Laura, Kudchadkar Sapna, Duncan Christine N, Pike Francis, Carpenter Paul A, Jacobsohn David, Bollard Catherine M, Cruz Conrad Russell Y, Malatpure Abhijeet, Farag Sherif, Renbarger Jamie, Little Morgan R, Gafken Phillip R, Krance Robert A, Cooke Kenneth R, Paczesny Sophie

Antigen-specific T cell responses correlate with decreased occurrence of acute GVHD in a multicenter contemporary cohort

在一项多中心当代队列研究中,抗原特异性T细胞反应与急性GVHD发生率降低相关。

Cruz, Conrad Russell Y; Bo, Na; Bakoyannis, Giorgos; Wright, Kaylor E; Chorvinsky, Elizabeth A; Powell, Allison; Bollard, Catherine M; Jacobsohn, David; Cooke, Kenneth R; Duncan, Christine; Krance, Robert M; Carpenter, Paul A; Rowan, Courtney M; Paczesny, Sophie

The HIV Latency Reversal Agent HODHBt Enhances NK Cell Effector and Memory-Like Functions by Increasing Interleukin-15-Mediated STAT Activation

HIV潜伏期逆转剂HODHBt通过增强白细胞介素-15介导的STAT激活来增强NK细胞的效应和记忆样功能。

Amanda B Macedo ,Callie Levinger ,Bryan N Nguyen ,Jonathan Richard ,Mamta Gupta ,Conrad Russell Y Cruz ,Andrés Finzi ,Katherine B Chiappinelli ,Keith A Crandall ,Alberto Bosque

Comparable transforming growth factor beta-mediated immune suppression in ex vivo-expanded natural killer cells from cord blood and peripheral blood: implications for adoptive immunotherapy

脐带血和外周血中体外扩增的自然杀伤细胞中转化生长因子β介导的免疫抑制相当:对过继免疫治疗的意义

Kajal Chaudhry, Ehsan Dowlati, Mark D Long, Ashley Geiger, Haili Lang, Eduardo C Gomez, Nethaji Muniraj, Carlos E Sanchez, Prashant K Singh, Song Liu, Catherine M Bollard, Conrad Russell Y Cruz

Spike-directed vaccination elicits robust spike-specific T-cell response, including to mutant strains

针对刺突的疫苗接种可引发强烈的刺突特异性 T 细胞反应,包括对突变菌株的反应

Maja Stanojevic, Ashley Geiger, Brita Ostermeier, Danielle Sohai, Christopher Lazarski, Haili Lang, Mariah Jensen-Wachspress, Kathleen Webber, Peter Burbelo, Jeffrey Cohen, Michael D Keller, Catherine M Bollard, Conrad Russell Y Cruz

Co-transducing B7H3 CAR-NK cells with the DNR preserves their cytolytic function against GBM in the presence of exogenous TGF-β

将 B7H3 CAR-NK 细胞与 DNR 共转导可在外源性 TGF-β 存在的情况下保留其针对 GBM 的细胞溶解功能

Kajal Chaudhry, Ashley Geiger, Ehsan Dowlati, Haili Lang, Danielle K Sohai, Eugene I Hwang, Christopher A Lazarski, Eric Yvon, Matthias Holdhoff, Richard Jones, Barbara Savoldo, Conrad Russell Y Cruz, Catherine M Bollard