文献库，生知库 | 链接生命科学的每一步

DJ-1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons

DJ-1 不是脱糖酶，对细胞防御甲基乙二醛对神经元的损伤有一定贡献

期刊:Journal of Neurochemistry

影响因子:4.2

doi:10.1111/jnc.15656

Melissa Conti Mazza, Sarah C Shuck, Jiusheng Lin, Michael A Moxley, John Termini, Mark R Cookson, Mark A Wilson

Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo

帕金森病相关激酶 LRRK2 的慢性抑制的临床前建模揭示了体内内溶酶体系统功能的改变

期刊:Molecular Neurodegeneration

影响因子:14.9

doi:10.1186/s13024-021-00441-8

Jillian H Kluss, Melissa Conti Mazza, Yan Li, Claudia Manzoni, Patrick A Lewis, Mark R Cookson, Adamantios Mamais

Stereotaxic Intracranial Delivery of Chemicals, Proteins or Viral Vectors to Study Parkinson's Disease

利用立体定向颅内递送化学物质、蛋白质或病毒载体研究帕金森病

期刊:Jove-Journal of Visualized Experiments

影响因子:1

doi:10.3791/62128

Landeck, Natalie; Conti Mazza, Melissa; Duffy, Megan; Bishop, Christopher; Sortwell, Caryl E; Cookson, Mark R

Generation of iPSC line from a Parkinson patient with PARK7 mutation and CRISPR-edited Gibco human episomal iPSC line to mimic PARK7 mutation

从具有 PARK7 突变的帕金森病患者中生成 iPSC 系，并通过 CRISPR 编辑 Gibco 人类游离型 iPSC 系来模拟 PARK7 突变

期刊:Stem Cell Research

影响因子:0.8

doi:10.1016/j.scr.2021.102506

Melissa Conti Mazza, Alexandra Beilina, Dorien A Roosen, David Hauser, Mark R Cookson

Striatal serotonin transporter gain-of-function in L-DOPA-treated, hemi-parkinsonian rats

左旋多巴治疗的半侧帕金森病大鼠纹状体血清素转运体功能获得性改变

DJ-1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons

DJ-1 不是脱糖酶，对细胞防御甲基乙二醛对神经元的损伤有一定贡献

Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo

帕金森病相关激酶 LRRK2 的慢性抑制的临床前建模揭示了体内内溶酶体系统功能的改变

Stereotaxic Intracranial Delivery of Chemicals, Proteins or Viral Vectors to Study Parkinson's Disease

利用立体定向颅内递送化学物质、蛋白质或病毒载体研究帕金森病

Generation of iPSC line from a Parkinson patient with PARK7 mutation and CRISPR-edited Gibco human episomal iPSC line to mimic PARK7 mutation

从具有 PARK7 突变的帕金森病患者中生成 iPSC 系，并通过 CRISPR 编辑 Gibco 人类游离型 iPSC 系来模拟 PARK7 突变