日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ClpC1-targeting peptide natural products differentially dysregulate the proteome of Mycobacterium tuberculosis

ClpC1靶向肽天然产物差异性地扰乱结核分枝杆菌的蛋白质组

Barter, Isabel K; Bedding, Max J; Leodolter, Julia; Maxwell, Joshua W C; Hawkins, Paige M E; Stevens, Maxwell T; McNeil, Matthew B; Jowsey, William J; Wang, Trixie; Quan, Diana; Junker, Sabryna; Flórido, Manuela; Hesselson, Daniel; Cook, Gregory M; Clausen, Tim; Britton, Warwick J; Larance, Mark; Payne, Richard J

Introducing CLipPA lipid chemodiversity to enzymatically truncated polymyxin B: a soft drug strategy to combat Gram-negative pathogens

将CLipPA脂质化学多样性引入酶切截短的多粘菌素B:一种对抗革兰氏阴性病原体的软药物策略

Na, Tae-Ung; Hermant, Yann O; Siow, Andrew; Owen, Jeremy G; Chan, Susanna T S; Painter, Gavin F; Hanna, Cameron C; Daysh, Zillah; Goggin, Beatrix L; Allison, Jane R; Sander, Veronika; Davidson, Alan J; Campbell, Georgia; Ferguson, Scott A; Cook, Gregory M; Harris, Paul W R; Brimble, Margaret A; Cameron, Alan J

Metabolic perturbation reduces antibiotic tolerance in Mycobacterium tuberculosis

代谢紊乱会降低结核分枝杆菌对抗生素的耐受性

Cheung, Chen-Yi; Samuels, Imogen; Klaus, Hannah R; Cook, Gregory M; McNeil, Matthew B

Remission spectroscopy resolves the mechanism of action of bedaquiline within living mycobacteria

反射光谱法解析了贝达喹啉在活分枝杆菌中的作用机制

Harrison, Suzanna H; Walters, Rowan C; Cheung, Chen-Yi; Springett, Roger J; Cook, Gregory M; Osman, Morwan M; Blaza, James N

Structure and assembly of the MmpL5/MmpS5 efflux transporter from Mycobacterium tuberculosis.

结核分枝杆菌MmpL5/MmpS5外排转运蛋白的结构和组装

Xiong Zhiqi, Yang Xiaolin, Wang Shule, Smart Caitlan J, Sisson Hazel M, Lin Zhenli, Hu Tianyu, Ran Yuting, Xu Chuyao, Yang Xiuna, Zhao Yao, Jowsey William J, Cook Gregory M, McNeil Matthew B, Guddat Luke W, Rao Zihe, Zhang Bing

ATP synthesis driven by atmospheric hydrogen concentrations

大气氢浓度驱动的ATP合成

Soom, Sarah; Moning, Stefan Urs; Cook, Gregory M; Lingford, James P; Kropp, Ashleigh; Tran, Sieu; Grinter, Rhys; Greening, Chris; von Ballmoos, Christoph

Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and aerobic respiration in mycobacteria.

冷冻电镜观察天然膜揭示了分枝杆菌中克雷布斯循环与有氧呼吸之间的密切联系

Di Trani Justin M, Yu Jiacheng, Courbon Gautier M, Lobez Rodriguez Ana Paula, Cheung Chen-Yi, Liang Yingke, Coupland Claire E, Bueler Stephanie A, Cook Gregory M, Brzezinski Peter, Rubinstein John L

Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity.

维拉帕米及其代谢物去甲维拉帕米抑制结核分枝杆菌MmpS5L5外排泵,从而增加贝达喹啉的活性

Fountain Adam J, Waller Natalie J E, Cheung Chen-Yi, Jowsey William, Chrisp Michael T, Troll Mark, Edelstein Paul H, Cook Gregory M, McNeil Matthew B, Ramakrishnan Lalita

Perinatal fentanyl exposure drives enduring addiction risk and central amygdala gene dysregulation

围产期芬太尼暴露会增加持续成瘾风险并导致中枢杏仁核基因失调

Wood, Courtney P; Shin, Yeji; Balaguer, Maria G; Campo, Paola; Dirik, Selen; Montoya, Bryan A; Cook, Gregory M R; Palermo, Gabrielle M; Naghshineh, Parsa K; Morgan, Alex; Rahman, Sara R M U; Palmer, Abraham A; Telese, Francesca; de Guglielmo, Giordano

Prolonged exposure to teixobactin generates cross-tolerance to other cell wall-targeting antimicrobials in Enterococcus faecalis

长期接触替索巴汀会导致粪肠球菌对其他靶向细胞壁的抗菌药物产生交叉耐受性。

Darnell, Rachel L; Knottenbelt, Melanie K; Rose, Olivia E; Cleary, Caitlin S B; Todd Rose, Francesca O; Hodgkinson, Hannah; Wu, Yuezhou; Hussein, Maytham; Velkov, Tony; Gebhard, Susanne; Cook, Gregory M