日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Preclinical development of a cross-protective β-SARS-CoV-2 virus-like particle vaccine adjuvanted with MF59.

采用 MF59 佐剂的交叉保护性 β-SARS-CoV-2 病毒样颗粒疫苗的临床前开发。

Earnest Linda, Ruiz Daniel Fernandez, Edeling Melissa A, Montoya Julio Carrera, Yap Ashley Huey Yiing, Wong Chinn Yi, Holz Lauren E, Gras Stephanie, Collett Simon, Cooney James P, Davidson Kathryn C, Grimley Samantha L, Purcell Damian F J, Roberts Jason, Mumford Jamie, Tan Chee Wah, Wang Lin-Fa, Godfrey Dale I, Frieman Matthew, Hans Dhiraj, Vincan Elizabeth, Anderson Danielle E, Subbarao Kanta, Pellegrini Marc, Mackenzie Jason M, Rockman Steven, Heath William R, Torresi Joseph

A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.

一种新型PLpro抑制剂改善了新冠肺炎长期症状的临床前模型的结果

M Bader Stefanie, Calleja Dale J, Devine Shane M, Kuchel Nathan W, Lu Bernadine G C, Wu Xinyu, Birkinshaw Richard W, Bhandari Reet, Loi Katie, Volpe Rohan, Khakham Yelena, Au Amanda E, Blackmore Timothy R, Mackiewicz Liana, Dayton Merle, Schaefer Jan, Scherer Lena, Stock Angus T, Cooney James P, Schoffer Kael, Maluenda Ana, Kleeman Elizabeth A, Davidson Kathryn C, Allison Cody C, Ebert Gregor, Chen Gong, Katneni Kasiram, Klemm Theresa A, Nachbur Ueli, Georgy Smitha Rose, Czabotar Peter E, Hannan Anthony J, Putoczki Tracy L, Tanzer Maria, Pellegrini Marc, Lechtenberg Bernhard C, Charman Susan A, Call Melissa J, Mitchell Jeffrey P, Lowes Kym N, Lessene Guillaume, Doerflinger Marcel, Komander David

IL-1β drives SARS-CoV-2-induced disease independently of the inflammasome and pyroptosis signalling.

IL-1β 驱动 SARS-CoV-2 引起的疾病,与炎症小体和细胞焦亡信号无关

M Bader Stefanie, Scherer Lena, Schaefer Jan, Cooney James P, Mackiewicz Liana, Dayton Merle, Georgy Smitha Rose, Davidson Kathryn C, Allison Cody C, Herold Marco J, Strasser Andreas, Pellegrini Marc, Doerflinger Marcel

A novel chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and scaffold domains from HKU-1 elicits potent neutralising antibody responses

一种新型嵌合冠状病毒刺突蛋白疫苗,结合了SARS-CoV-2的受体结合域(RBD)和HKU-1的支架结构域,可诱导产生强效的中和抗体反应。

Zoest, Veronica P; Lee, Wen Shi; Murdiyarso, Lydia; Burmas, Lauren; Pymm, Phillip; Esterbauer, Robyn; Kelly, Andrew; Kelly, Hannah G; Barber-Axthelm, Isaac; Cooney, James P; Davidson, Kathryn C; Dayton, Merle; McAleese, Courtney E; Gillard, Marianne; Hughes, Karen; Jones, Martina L; Pellegrini, Marc; Tham, Wai-Hong; Hughes, Ben; Kent, Stephen J; Wheatley, Adam K; Juno, Jennifer A; Tan, Hyon-Xhi

mRNA vaccines encoding membrane-anchored RBDs of SARS-CoV-2 mutants induce strong humoral responses and can overcome immune imprinting

编码SARS-CoV-2突变体膜锚定RBD的mRNA疫苗可诱导强烈的体液免疫反应,并能克服免疫印迹。

Al-Wassiti, Hareth A; Fabb, Stewart A; Grimley, Samantha L; Kochappan, Ruby; Ho, Joan K; Wong, Chinn Yi; Tan, Chee Wah; Payne, Thomas J; Takanashi, Asuka; Lee, Chee Leng; Mugan, Rekha Shandre; Sicilia, Horatio; Teo, Serena L Y; McAuley, Julie; Ellenberg, Paula; Cooney, James P; Davidson, Kathryn C; Bowen, Richard; Pellegrini, Marc; Rockman, Steven; Godfrey, Dale I; Nolan, Terry M; Wang, Lin-Fa; Deliyannis, Georgia; Purcell, Damian F J; Pouton, Colin W

Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2.

Fc工程化的ACE2-Fc是一种针对SARS-CoV-2的强效多功能制剂

Wines Bruce D, Kurtovic Liriye, Trist Halina M, Esparon Sandra, Lopez Ester, Chappin Klasina, Chan Li-Jin, Mordant Francesca L, Lee Wen Shi, Gherardin Nicholas A, Patel Sheila K, Hartley Gemma E, Pymm Phillip, Cooney James P, Beeson James G, Godfrey Dale I, Burrell Louise M, van Zelm Menno C, Wheatley Adam K, Chung Amy W, Tham Wai-Hong, Subbarao Kanta, Kent Stephen J, Hogarth P Mark

Programmed cell death: the pathways to severe COVID-19?

程序性细胞死亡:导致重症新冠肺炎的途径?

Bader, Stefanie M; Cooney, James P; Pellegrini, Marc; Doerflinger, Marcel

The role of MKK4 in T-cell development and immunity to viral infections.

MKK4 在 T 细胞发育和对病毒感染的免疫中的作用

Preston Simon P, Doerflinger Marcel, Scott Hamish W, Allison Cody C, Horton Miles, Cooney James, Pellegrini Marc

MZC Gel Inhibits SHIV-RT and HSV-2 in Macaque Vaginal Mucosa and SHIV-RT in Rectal Mucosa

MZC 凝胶可抑制猕猴阴道粘膜中的 SHIV-RT 和 HSV-2 以及直肠粘膜中的 SHIV-RT

Giulia Calenda, Guillermo Villegas, Patrick Barnable, Claudia Litterst, Keith Levendosky, Agegnehu Gettie, Michael L Cooney, James Blanchard, José A Fernández-Romero, Thomas M Zydowsky, Natalia Teleshova

Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus

细胞凋亡抑制蛋白可阻止乙型肝炎病毒的清除

Ebert, Gregor; Preston, Simon; Allison, Cody; Cooney, James; Toe, Jesse G; Stutz, Michael D; Ojaimi, Samar; Scott, Hamish W; Baschuk, Nikola; Nachbur, Ueli; Torresi, Joseph; Chin, Ruth; Colledge, Danielle; Li, Xin; Warner, Nadia; Revill, Peter; Bowden, Scott; Silke, John; Begley, C Glenn; Pellegrini, Marc