日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural and Functional Determinants of AC8 Trafficking, Targeting and Responsiveness in Lipid Raft Microdomains

脂筏微区中AC8转运、靶向和反应的结构和功能决定因素

Tabbasum, Valentina G; Cooper, Dermot M F

TRPC1 contributes to the Ca2+-dependent regulation of adenylate cyclases

TRPC1参与腺苷酸环化酶的Ca2+依赖性调节

Willoughby, Debbie; Ong, Hwei Ling; De Souza, Lorena Brito; Wachten, Sebastian; Ambudkar, Indu S; Cooper, Dermot M F

Unexpected Regulation of MicroRNA Activity by a Protein♦: The RNA-binding Protein TDP-43 Selectively Disrupts MicroRNA-1/206 Incorporation into the RNA-induced Silencing Complex

蛋白质对microRNA活性的意外调控♦:RNA结合蛋白TDP-43选择性地干扰microRNA-1/206整合到RNA诱导的沉默复合物中

Delint-Ramirez, Ilse; Willoughby, Debbie; Hammond, Gerald R V; Ayling, Laura J; Cooper, Dermot M F

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions

高功能化三联吡啶作为AKAP-PKA相互作用的竞争性抑制剂

Schäfer, Gesa; Milić, Jelena; Eldahshan, Adeeb; Götz, Frank; Zühlke, Kerstin; Schillinger, Christian; Kreuchwig, Annika; Elkins, Jonathan M; Abdul Azeez, Kamal R; Oder, Andreas; Moutty, Marie C; Masada, Nanako; Beerbaum, Monika; Schlegel, Brigitte; Niquet, Sylvia; Schmieder, Peter; Krause, Gerd; von Kries, Jens Peter; Cooper, Dermot M F; Knapp, Stefan; Rademann, Jörg; Rosenthal, Walter; Klussmann, Enno

AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex

AKAP79、PKC、PKA 和 PDE4 参与 Gq 偶联的毒蕈碱受体和腺苷酸环化酶 2 cAMP 信号复合物。

Shen, Jia X; Cooper, Dermot M F

Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas Gβγ subunits exert opposing effects depending on the G-protein source.

毒蕈碱受体通过新的磷酸化位点刺激 AC2,而 Gββ 亚基则根据 G 蛋白的来源发挥相反的作用

Shen Jia X, Wachten Sebastian, Halls Michelle L, Everett Katy L, Cooper Dermot M F

A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex

AC8 中的一个关键磷酸化位点通过 AC8-AKAP79-PKA 信号复合物介导 Ca(2+) 依赖性 cAMP 动态的调控。

Willoughby, Debbie; Halls, Michelle L; Everett, Katy L; Ciruela, Antonio; Skroblin, Philipp; Klussmann, Enno; Cooper, Dermot M F

Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu.

腺苷酸环化酶 AC8 通过在富含胆固醇的环境中募集肌动蛋白细胞骨架来直接控制其微环境

Ayling Laura J, Briddon Stephen J, Halls Michelle L, Hammond Gerald R V, Vaca Luis, Pacheco Jonathan, Hill Stephen J, Cooper Dermot M F

Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex

预组装的 RXFP1、AKAP79、AC2、β-arrestin 2、PDE4D3 复合物介导亚皮摩尔级松弛素信号传导。

Halls, Michelle L; Cooper, Dermot M F

Direct demonstration of discrete Ca2+ microdomains associated with different isoforms of adenylyl cyclase

直接证明与腺苷酸环化酶不同亚型相关的离散Ca2+微区

Willoughby, Debbie; Wachten, Sebastian; Masada, Nanako; Cooper, Dermot M F