日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ApoE4 requires lipidation enhancement to resolve cellular lipid and protein abnormalities following NPC1 inhibition.

ApoE4 需要脂化增强来解决 NPC1 抑制后细胞脂质和蛋白质异常

Di Biase Erika, Connolly Kyle J, Crumpton Ingrid, Cooper Oliver, Hallett Penelope J, Isacson Ole

Upstream lipid and metabolic systems are potential causes of Alzheimer's disease, Parkinson's disease and dementias

上游脂质和代谢系统是阿尔茨海默病、帕金森病和痴呆症的潜在病因。

Cooper, Oliver; Hallett, Penny; Isacson, Ole

Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease

自体iPSC衍生的多巴胺神经元移植到帕金森病非人灵长类动物模型后成功发挥功能

Hallett, Penelope J; Deleidi, Michela; Astradsson, Arnar; Smith, Gaynor A; Cooper, Oliver; Osborn, Teresia M; Sundberg, Maria; Moore, Michele A; Perez-Torres, Eduardo; Brownell, Anna-Liisa; Schumacher, James M; Spealman, Roger D; Isacson, Ole

Synthesis, characterization, and reactivity of a uranium(VI) carbene imido oxo complex

铀(VI)卡宾亚胺氧配合物的合成、表征及反应活性研究

Lu, Erli; Cooper, Oliver J; McMaster, Jonathan; Tuna, Floriana; McInnes, Eric J L; Lewis, William; Blake, Alexander J; Liddle, Stephen T

Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression

帕金森病脑区及α-突触核蛋白过表达转基因小鼠模型中全长α-突触核蛋白及其三种选择性剪接变体的转录表达水平

McLean, Jesse R; Hallett, Penelope J; Cooper, Oliver; Stanley, Michael; Isacson, Ole

Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid

人类胚胎干细胞和帕金森病诱导多能干细胞分化为腹侧中脑多巴胺能神经元需要高活性的SHH、FGF8a以及视黄酸介导的特异性区域化。

Cooper, Oliver; Hargus, Gunnar; Deleidi, Michela; Blak, Alexandra; Osborn, Teresia; Marlow, Elizabeth; Lee, Kristen; Levy, Adam; Perez-Torres, Eduardo; Yow, Alyssa; Isacson, Ole

Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors.

帕金森病患者来源的诱导多能干细胞,不含病毒重编程因子

Soldner Frank, Hockemeyer Dirk, Beard Caroline, Gao Qing, Bell George W, Cook Elizabeth G, Hargus Gunnar, Blak Alexandra, Cooper Oliver, Mitalipova Maisam, Isacson Ole, Jaenisch Rudolf

No evidence for disease-like processes in fetal transplants

胎儿移植中未发现类似疾病的过程

Hallett, Penelope J; Cooper, Oliver; Isacson, Ole

Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum

命运图谱和谱系分析表明,在多巴胺耗竭的纹状体中注入转化生长因子α和noggin后,纹状体中产生了大量的神经母细胞。

de Chevigny, Antoine; Cooper, Oliver; Vinuela, Angel; Reske-Nielsen, Casper; Lagace, Diane C; Eisch, Amelia J; Isacson, Ole

Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease

选择性COX-2抑制剂可阻止帕金森病大鼠模型中多巴胺能神经元的进行性退化

Sánchez-Pernaute, Rosario; Ferree, Andrew; Cooper, Oliver; Yu, Meixiang; Brownell, Anna-Liisa; Isacson, Ole