日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanism-based approach in designing patient-specific combination therapies for nonsense mutation diseases

基于机制的方法设计针对无义突变疾病的患者特异性联合疗法

Bhat, Saleem Y; Bhattacharya, Arpan; Li, Hong; Cui, Xiaonan; Lueck, John D; Goldman, Yale E; Cooperman, Barry S

Near-cognate tRNAs enhance tRNA rejection and prime the ribosome for rapid subsequent tRNA testing

近同源tRNA增强了tRNA的排斥作用,并使核糖体做好快速进行后续tRNA检测的准备。

Fritsch, Clark; Bhattacharya, Arpan; Ng, Martin Y; Li, Hong; Nelson, Philip C; Cooperman, Barry S; Goldman, Yale E

A High-Throughput Assay for In Vitro Determination of Release Factor-Dependent Peptide Release from a Pretermination Complex by Fluorescence Anisotropy-Application to Nonsense Suppressor Screening and Mechanistic Studies

利用荧光各向异性技术体外测定预终止复合物中释放因子依赖性肽释放的高通量检测方法——应用于无义抑制子筛选和机制研究

Ghelfi, Mikel D; Bhat, Saleem Y; Li, Hong; Cooperman, Barry S

Structural dynamics of translation elongation factor Tu during aa-tRNA delivery to the ribosome

翻译延伸因子Tu在氨酰tRNA递送至核糖体过程中的结构动力学

Kavaliauskas, Darius; Chen, Chunlai; Liu, Wei; Cooperman, Barry S; Goldman, Yale E; Knudsen, Charlotte R

E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form

大肠杆菌延伸因子Tu与GTP类似物结合后,呈现出与GDP结合形式相同的开放构象。

Johansen, Jesper S; Kavaliauskas, Darius; Pfeil, Shawn H; Blaise, Mickaël; Cooperman, Barry S; Goldman, Yale E; Thirup, Søren S; Knudsen, Charlotte R

New in Vitro Assay Measuring Direct Interaction of Nonsense Suppressors with the Eukaryotic Protein Synthesis Machinery

一种新的体外检测方法,用于测量无义抑制子与真核生物蛋白质合成机制的直接相互作用。

Ng, Martin Y; Zhang, Haibo; Weil, Amy; Singh, Vijay; Jamiolkowski, Ryan; Baradaran-Heravi, Alireza; Roberge, Michel; Jacobson, Allan; Friesen, Westley; Welch, Ellen; Goldman, Yale E; Cooperman, Barry S

tRNA Fluctuations Observed on Stalled Ribosomes Are Suppressed during Ongoing Protein Synthesis

在停滞的核糖体上观察到的tRNA波动在持续的蛋白质合成过程中受到抑制

Jamiolkowski, Ryan M; Chen, Chunlai; Cooperman, Barry S; Goldman, Yale E

Ribosome-Templated Azide-Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry

核糖体模板叠氮-炔环加成反应:原位点击化学合成强效大环内酯类抗生素

Glassford, Ian; Teijaro, Christiana N; Daher, Samer S; Weil, Amy; Small, Meagan C; Redhu, Shiv K; Colussi, Dennis J; Jacobson, Marlene A; Childers, Wayne E; Buttaro, Bettina; Nicholson, Allen W; MacKerell, Alexander D Jr; Cooperman, Barry S; Andrade, Rodrigo B

Electrophoretic Deformation of Individual Transfer RNA Molecules Reveals Their Identity

单个转移RNA分子的电泳形变揭示了它们的身份

Henley, Robert Y; Ashcroft, Brian Alan; Farrell, Ian; Cooperman, Barry S; Lindsay, Stuart M; Wanunu, Meni

Kinetics of initiating polypeptide elongation in an IRES-dependent system

IRES依赖系统中起始多肽链延伸的动力学

Zhang, Haibo; Ng, Martin Y; Chen, Yuanwei; Cooperman, Barry S