Copani Agata相关文献与解析，生知库 | 链接生命科学的每一步

Lanza, Marika; Scuruchi, Michele; Saitta, Alessandra; Basilotta, Rossella; Aliquò, Federica; Casili, Giovanna; Esposito, Emanuela; Copani, Agata; Oddo, Salvatore; Caccamo, Antonella

阿尔茨海默症

Mouse

细胞生物学

发表日期：2026

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(±)-2-Cyclohexyl-5-methoxy-2H-chromene, a Synthetic 5-Methoxyflavone Derivative, Is a Selective DNA Polymerase-β Inhibitor with Neuroprotective Activity against β-Amyloid Toxicity

(±)-2-环己基-5-甲氧基-2H-色烯，一种合成的5-甲氧基黄酮衍生物，是一种选择性DNA聚合酶-β抑制剂，具有对抗β-淀粉样蛋白毒性的神经保护活性。

期刊:ACS Chemical Neuroscience

影响因子:3.9

doi:10.1021/acschemneuro.5c00712

Guccione, Salvatore; Merlo, Sara; Tagliapietra, Silvia; Pappalardo, Matteo; Binello, Arianna; Barge, Alessandro; Basile, Livia; Sortino, Maria Angela; Cravotto, Giancarlo; Copani, Agata

毒理研究

发表日期：2026

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Computational modeling of ATM signaling: a predictive framework for drug repurposing in ataxia-telangiectasia

ATM信号传导的计算建模：共济失调毛细血管扩张症药物再利用的预测框架

期刊:npj Systems Biology and Applications

影响因子:3.5

doi:10.1038/s41540-025-00629-4

Merulla, Aurora Eliana; Di Salvatore, Valentina; Gullotta, Giorgia Serena; Maleki, Avisa; Russo, Giulia; Caraci, Filippo; Copani, Agata; Pappalardo, Francesco

Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia

靶向mGlu受体以优化抗精神病活性和精神分裂症疾病改善作用

期刊:Frontiers in Psychiatry

影响因子:3.2

doi:10.3389/fpsyt.2019.00049

Nicoletti, Ferdinando; Orlando, Rosamaria; Di Menna, Luisa; Cannella, Milena; Notartomaso, Serena; Mascio, Giada; Iacovelli, Luisa; Matrisciano, Francesco; Fazio, Francesco; Caraci, Filippo; Copani, Agata; Battaglia, Giuseppe; Bruno, Valeria

A promising connection between BDNF and Alzheimer's disease

脑源性神经营养因子（BDNF）与阿尔茨海默病之间存在着令人期待的联系

期刊:Aging-Us

影响因子:3.9

doi:10.18632/aging.101518

Giuffrida, Maria Laura; Copani, Agata; Rizzarelli, Enrico

Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?

神经胶质细胞中的代谢型谷氨酸受体：神经保护的新潜在靶点？

期刊:Frontiers in Molecular Neuroscience

影响因子:3.8

doi:10.3389/fnmol.2018.00414

Spampinato, Simona Federica; Copani, Agata; Nicoletti, Ferdinando; Sortino, Maria Angela; Caraci, Filippo

Monomeric Ã-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons.

单体β-淀粉样蛋白与1型胰岛素样生长因子受体相互作用，为神经元提供能量供应

期刊:Frontiers in Cellular Neuroscience

影响因子:4

doi:10.3389/fncel.2015.00297

Giuffrida Maria L, Tomasello Marianna F, Pandini Giuseppe, Caraci Filippo, Battaglia Giuseppe, Busceti Carla, Di Pietro Paola, Pappalardo Giuseppe, Attanasio Francesco, Chiechio Santina, Bagnoli Silvia, Nacmias Benedetta, Sorbi Sandro, Vigneri Riccardo, Rizzarelli Enrico, Nicoletti Ferdinando, Copani Agata

神经科学

发表日期：2015

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TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease

TGF-β1通路作为阿尔茨海默病神经保护的新靶点

期刊:CNS Neuroscience & Therapeutics

影响因子:5

doi:10.1111/j.1755-5949.2009.00115.x

Caraci, Filippo; Battaglia, Giuseppe; Bruno, Valeria; Bosco, Paolo; Carbonaro, Viviana; Giuffrida, Maria Laura; Drago, Filippo; Sortino, Maria Angela; Nicoletti, Ferdinando; Copani, Agata

mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists

mGlu2代谢型谷氨酸受体抑制炎症性疼痛，并介导双重mGlu2/mGlu3受体激动剂的镇痛活性。

期刊:Molecular Pain

影响因子:2.8

doi:10.1186/1744-8069-7-6

Zammataro, Magda; Chiechio, Santina; Montana, Michael C; Traficante, Anna; Copani, Agata; Nicoletti, Ferdinando; Gereau, Robert W 4th

Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine

NF-κB通路对原代背根神经节神经元中代谢型谷氨酸受体2/3表达的转录调控：L-乙酰肉碱镇痛作用的可能机制

期刊:Molecular Pain

影响因子:2.8

doi:10.1186/1744-8069-2-20

Chiechio, Santina; Copani, Agata; De Petris, Laura; Morales, Maria Elena P; Nicoletti, Ferdinando; Gereau, Robert W 4th

Aberrant Cell Cycle Gene Expression in a Transgenic Mouse Model of Alzheimer's Disease

阿尔茨海默病转基因小鼠模型中细胞周期基因表达异常

(±)-2-Cyclohexyl-5-methoxy-2H-chromene, a Synthetic 5-Methoxyflavone Derivative, Is a Selective DNA Polymerase-β Inhibitor with Neuroprotective Activity against β-Amyloid Toxicity

(±)-2-环己基-5-甲氧基-2H-色烯，一种合成的5-甲氧基黄酮衍生物，是一种选择性DNA聚合酶-β抑制剂，具有对抗β-淀粉样蛋白毒性的神经保护活性。

Computational modeling of ATM signaling: a predictive framework for drug repurposing in ataxia-telangiectasia

ATM信号传导的计算建模：共济失调毛细血管扩张症药物再利用的预测框架

Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia

靶向mGlu受体以优化抗精神病活性和精神分裂症疾病改善作用

A promising connection between BDNF and Alzheimer's disease

脑源性神经营养因子（BDNF）与阿尔茨海默病之间存在着令人期待的联系

Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?

神经胶质细胞中的代谢型谷氨酸受体：神经保护的新潜在靶点？

Monomeric Ã-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons.

单体β-淀粉样蛋白与1型胰岛素样生长因子受体相互作用，为神经元提供能量供应

TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease

TGF-β1通路作为阿尔茨海默病神经保护的新靶点

mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists

mGlu2代谢型谷氨酸受体抑制炎症性疼痛，并介导双重mGlu2/mGlu3受体激动剂的镇痛活性。

Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine

NF-κB通路对原代背根神经节神经元中代谢型谷氨酸受体2/3表达的转录调控：L-乙酰肉碱镇痛作用的可能机制

Aberrant Cell Cycle Gene Expression in a Transgenic Mouse Model of Alzheimer's Disease

阿尔茨海默病转基因小鼠模型中细胞周期基因表达异常

(±)-2-Cyclohexyl-5-methoxy-2H-chromene, a Synthetic 5-Methoxyflavone Derivative, Is a Selective DNA Polymerase-β Inhibitor with Neuroprotective Activity against β-Amyloid Toxicity

(±)-2-环己基-5-甲氧基-2H-色烯，一种合成的5-甲氧基黄酮衍生物，是一种选择性DNA聚合酶-β抑制剂，具有对抗β-淀粉样蛋白毒性的神经保护活性。

Computational modeling of ATM signaling: a predictive framework for drug repurposing in ataxia-telangiectasia

ATM信号传导的计算建模：共济失调毛细血管扩张症药物再利用的预测框架

Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia

靶向mGlu受体以优化抗精神病活性和精神分裂症疾病改善作用

A promising connection between BDNF and Alzheimer's disease

脑源性神经营养因子（BDNF）与阿尔茨海默病之间存在着令人期待的联系

Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?

神经胶质细胞中的代谢型谷氨酸受体：神经保护的新潜在靶点？

Monomeric Ã-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons.

单体β-淀粉样蛋白与1型胰岛素样生长因子受体相互作用，为神经元提供能量供应

TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease

TGF-β1通路作为阿尔茨海默病神经保护的新靶点

mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists

mGlu2代谢型谷氨酸受体抑制炎症性疼痛，并介导双重mGlu2/mGlu3受体激动剂的镇痛活性。

Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine

NF-κB通路对原代背根神经节神经元中代谢型谷氨酸受体2/3表达的转录调控：L-乙酰肉碱镇痛作用的可能机制

Monomeric Ã-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons.