日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9

ATX968 的发现:一种口服有效的 DHX9 变构抑制剂

Daniels, Matthew H; Castro, Jennifer; Lee, Young-Tae; Gotur, Deepali; Knockenhauer, Kevin E; Grigoriu, Simina; Lockbaum, Gordon J; Cheong, Jae Eun; Lu, Chuang; Brennan, David; Buker, Shane M; Liu, Julie; Yao, Shihua; Sparling, Brian A; Sickmier, E Allen; Ribich, Scott; Blakemore, Steve J; Silver, Serena J; Boriack-Sjodin, P Ann; Duncan, Kenneth W; Copeland, Robert A

Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.

核糖核酸外切酶 XRN1 作为癌症靶点的特性分析以及腺苷-3',5'-二磷酸作为强效酶抑制剂的鉴定

Lockbaum Gordon J, Lynes Maureen M, Shen Sophie A, Liu Julie, Holt Nicholas, Nayak Sunaina P, Knockenhauer Kevin E, Yao Shihua, Sickmier E Allen, Raman Anugraha, Wu Jie, Case April, Shehaj Livia, Buker Shane M, Grigoriu Simina, Ribich Scott, Blakemore Stephen J, Sparling Brian A, Duncan Kenneth W, Copeland Robert A, Silver Serena J, Boriack-Sjodin P Ann

Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement

发现驱动蛋白KIF18A抑制剂ATX020:硅原子取代的战术应用

Sparling, Brian A; Lee, Hyelee; Zablocki, Mary-Margaret; Lynes, Maureen M; Grigoriu, Simina; Shehaj, Livia; Lockbaum, Gordon J; Khan, Sanjoy K; Hotz, Taylor; Lee, Young-Tae; Buker, Shane M; Gotur, Deepali; Lu, Chuang; Ribich, Scott; Blakemore, Stephen J; Boriack-Sjodin, P Ann; Silver, Serena J; Copeland, Robert A; Duncan, Kenneth W

Special Issue on Epigenetics: Targeting Chromatin- and RNA- Modifications

表观遗传学特刊:靶向染色质和RNA修饰

Copeland, Robert A; Huryn, Donna M

Protein methyltransferase inhibitors as precision cancer therapeutics: a decade of discovery

蛋白质甲基转移酶抑制剂作为精准癌症疗法:十年的发现

Copeland, Robert A

Epigenetic Medicinal Chemistry

表观遗传药物化学

Copeland, Robert A

The promise and peril of chemical probes

化学探针的机遇与风险

Arrowsmith, Cheryl H; Audia, James E; Austin, Christopher; Baell, Jonathan; Bennett, Jonathan; Blagg, Julian; Bountra, Chas; Brennan, Paul E; Brown, Peter J; Bunnage, Mark E; Buser-Doepner, Carolyn; Campbell, Robert M; Carter, Adrian J; Cohen, Philip; Copeland, Robert A; Cravatt, Ben; Dahlin, Jayme L; Dhanak, Dashyant; Edwards, Aled M; Frederiksen, Mathias; Frye, Stephen V; Gray, Nathanael; Grimshaw, Charles E; Hepworth, David; Howe, Trevor; Huber, Kilian V M; Jin, Jian; Knapp, Stefan; Kotz, Joanne D; Kruger, Ryan G; Lowe, Derek; Mader, Mary M; Marsden, Brian; Mueller-Fahrnow, Anke; Müller, Susanne; O'Hagan, Ronan C; Overington, John P; Owen, Dafydd R; Rosenberg, Saul H; Roth, Bryan; Ross, Ruth; Schapira, Matthieu; Schreiber, Stuart L; Shoichet, Brian; Sundström, Michael; Superti-Furga, Giulio; Taunton, Jack; Toledo-Sherman, Leticia; Walpole, Chris; Walters, Michael A; Willson, Timothy M; Workman, Paul; Young, Robert N; Zuercher, William J

EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity

EPZ011989,一种高效、口服有效的EZH2抑制剂,具有显著的体内活性。

Campbell, John E; Kuntz, Kevin W; Knutson, Sarah K; Warholic, Natalie M; Keilhack, Heike; Wigle, Tim J; Raimondi, Alejandra; Klaus, Christine R; Rioux, Nathalie; Yokoi, Akira; Kawano, Satoshi; Minoshima, Yukinori; Choi, Hyeong-Wook; Porter Scott, Margaret; Waters, Nigel J; Smith, Jesse J; Chesworth, Richard; Moyer, Mikel P; Copeland, Robert A

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

强效抑制DOT1L可治疗MLL融合白血病

Daigle, Scott R; Olhava, Edward J; Therkelsen, Carly A; Basavapathruni, Aravind; Jin, Lei; Boriack-Sjodin, P Ann; Allain, Christina J; Klaus, Christine R; Raimondi, Alejandra; Scott, Margaret Porter; Waters, Nigel J; Chesworth, Richard; Moyer, Mikel P; Copeland, Robert A; Richon, Victoria M; Pollock, Roy M

Fluorescence polarization method to characterize macrolide-ribosome interactions

利用荧光偏振法表征大环内酯类-核糖体相互作用

Yan, Kang; Hunt, Eric; Berge, John; May, Earl; Copeland, Robert A; Gontarek, Richard R