日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Correction: The biosynthesis of N-acyalated tryptazolone in Mycobacterium tuberculosis and related bacteria

更正:结核分枝杆菌及相关细菌中N-酰化曲普唑酮的生物合成

Kleetz, Julia; Grigg, Jason C; Hassan, Adam A; Ibtisam, Adriana; Copp, Janine N; Lian, Jennifer; Liu, Jie; Eltis, Lindsay D

The biosynthesis of N-acylated tryptazolone in Mycobacterium tuberculosis and related bacteria

结核分枝杆菌及相关细菌中N-酰化色氨酸唑酮的生物合成

Kleetz, Julia; Grigg, Jason C; Hassan, Adam A; Ibtisam, Adriana; Copp, Janine N; Lian, Jennifer; Liu, Jie; Eltis, Lindsay D

From Binding to Catalysis: Emergence of a Rudimentary Enzyme Conferring Intrinsic Antibiotic Resistance

从结合到催化:赋予固有抗生素耐药性的原始酶的出现

Lemay-St-Denis, Claudèle; Cellier-Goetghebeur, Stella; St-Aubin, Maxime; Ide, Keigo; Copp, Janine N; Tsuda, Soichiro; Ben-Tal, Nir; Kolodny, Rachel; Pelletier, Joelle N

A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening.

一种促进捕获基因高水平表达的宏基因组文库克隆策略,可实现高效的功能筛选

Rich Michelle H, Sharrock Abigail V, Mulligan Timothy S, Matthews Frazer, Brown Alistair S, Lee-Harwood Hannah R, Williams Elsie M, Copp Janine N, Little Rory F, Francis Jenni J B, Horvat Claire N, Stevenson Luke J, Owen Jeremy G, Saxena Meera T, Mumm Jeff S, Ackerley David F

A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype

多种假定蛋白质中保守的SH3样折叠结构可四聚化形成氧化还原酶,从而赋予其抗菌耐药表型。

Lemay-St-Denis, Claudèle; Alejaldre, Lorea; Jemouai, Zakaria; Lafontaine, Kiana; St-Aubin, Maxime; Hitache, Katia; Valikhani, Donya; Weerasinghe, Nuwani W; Létourneau, Myriam; Thibodeaux, Christopher J; Doucet, Nicolas; Baron, Christian; Copp, Janine N; Pelletier, Joelle N

Deciphering the biosynthesis of a novel lipid in Mycobacterium tuberculosis expands the known roles of the nitroreductase superfamily

破译结核分枝杆菌中一种新型脂质的生物合成途径,拓展了硝基还原酶超家族的已知功能。

Grigg, Jason C; Copp, Janine N; Krekhno, Jessica M C; Liu, Jie; Ibrahimova, Aygun; Eltis, Lindsay D

A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening

一种促进捕获基因高水平表达的宏基因组文库克隆策略,可实现高效的功能筛选。

Rich, Michelle H; Sharrock, Abigail V; Mulligan, Timothy S; Matthews, Frazer; Brown, Alistair S; Lee-Harwood, Hannah R; Williams, Elsie M; Copp, Janine N; Little, Rory F; Francis, Jenni Jb; Horvat, Claire N; Stevenson, Luke J; Owen, Jeremy G; Saxena, Meera T; Mumm, Jeff S; Ackerley, David F

Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications

对用于癌症基因治疗的亲脂性硝基芳香族前药系列进行构效关系研究

Ashoorzadeh, Amir; Mowday, Alexandra M; Guise, Christopher P; Silva, Shevan; Bull, Matthew R; Abbattista, Maria R; Copp, Janine N; Williams, Elsie M; Ackerley, David F; Patterson, Adam V; Smaill, Jeff B

Discovery of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases in Diverse Environmental Settings Suggests an Evolutionary Advantage Unrelated to Antibiotic Resistance

在多种环境条件下发现对甲氧苄啶高度耐药的DfrB二氢叶酸还原酶,表明其具有与抗生素耐药性无关的进化优势。

Cellier-Goetghebeur, Stella; Lafontaine, Kiana; Lemay-St-Denis, Claudèle; Tsamo, Princesse; Bonneau-Burke, Alexis; Copp, Janine N; Pelletier, Joelle N

Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active-site residues

通过活性位点残基的质量随机化揭示获得新的酶功能的细胞内复杂性

Hall, Kelsi R; Robins, Katherine J; Williams, Elsie M; Rich, Michelle H; Calcott, Mark J; Copp, Janine N; Little, Rory F; Schwörer, Ralf; Evans, Gary B; Patrick, Wayne M; Ackerley, David F