日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy

癌基因信号的矛盾激活作为癌症治疗策略

Matheus Henrique Dias, Anoek Friskes, Siying Wang, Joao M Fernandes Neto, Frank van Gemert, Soufiane Mourragui, Chrysa Papagianni, Hendrik J Kuiken, Sara Mainardi, Daniel Alvarez-Villanueva, Cor Lieftink, Ben Morris, Anna Dekker, Emma van Dijk, Lieke H S Wilms, Marcelo S da Silva, Robin A Jansen, An

ADARp150 counteracts whole genome duplication

ADARp150 可抑制全基因组复制

Frank van Gemert ,Alexandra Drakaki ,Isabel Morales Lozano ,Daniël de Groot ,Maud Schoot Uiterkamp ,Natalie Proost ,Cor Lieftink ,Marieke van de Ven ,Roderick L Beijersbergen ,Heinz Jacobs ,Hein Te Riele

Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse

通过功能遗传学鉴定的耐药持久细胞的脆弱性可以延缓肿瘤复发

Mengnuo Chen, Sara Mainardi, Cor Lieftink, Arno Velds, Iris de Rink, Chen Yang, Hendrik J Kuiken, Ben Morris, Finn Edwards, Fleur Jochems, Olaf van Tellingen, Manon Boeije, Natalie Proost, Robin A Jansen, Shifan Qin, Haojie Jin, J C Koen van der Mijn, Arnout Schepers, Subramanian Venkatesan, Wenxin

Molecular dependencies and genomic consequences of a global DNA damage tolerance defect

整体 DNA 损伤耐受缺陷的分子依赖性和基因组后果

Daniel de Groot, Aldo Spanjaard, Ronak Shah, Maaike Kreft, Ben Morris, Cor Lieftink, Joyce J I Catsman, Shirley Ormel, Matilda Ayidah, Bas Pilzecker, Olimpia Alessandra Buoninfante, Paul C M van den Berk, Roderick L Beijersbergen, Heinz Jacobs

PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair

PARG缺陷型肿瘤细胞对EXO1/FEN1介导的DNA修复的依赖性增强。

Christina Andronikou ,Kamila Burdova ,Diego Dibitetto ,Cor Lieftink ,Elke Malzer ,Hendrik J Kuiken ,Ewa Gogola ,Arnab Ray Chaudhuri ,Roderick L Beijersbergen ,Hana Hanzlikova ,Jos Jonkers ,Sven Rottenberg

PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription

PAXIP1 和 STAG2 聚合以维持 3D 基因组结构并促进启动子/增强子接触以实现应激激素依赖性转录

Isabel Mayayo-Peralta, Sebastian Gregoricchio, Karianne Schuurman, Selçuk Yavuz, Anniek Zaalberg, Aleksandar Kojic, Nina Abbott, Bart Geverts, Suzanne Beerthuijzen, Joseph Siefert, Tesa M Severson, Martijn van Baalen, Liesbeth Hoekman, Cor Lieftink, Maarten Altelaar, Roderick L Beijersbergen, Adriaa

Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly

位点特异性蛋白质组解码表明 Fpt1 是 RNA 聚合酶 III 组装的染色质相关负调节剂

Maria Elize van Breugel, Ila van Kruijsbergen, Chitvan Mittal, Cor Lieftink, Ineke Brouwer, Teun van den Brand, Roelof J C Kluin, Liesbeth Hoekman, Renée X Menezes, Tibor van Welsem, Andrea Del Cortona, Muddassir Malik, Roderick L Beijersbergen, Tineke L Lenstra, Kevin J Verstrepen, B Franklin Pugh,

Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma

基因筛查揭示了 BAP1 缺陷间皮瘤中新的可靶向弱点

Gaurav Kumar Pandey, Nick Landman, Hannah K Neikes, Danielle Hulsman, Cor Lieftink, Roderick Beijersbergen, Krishna Kalyan Kolluri, Sam M Janes, Michiel Vermeulen, Jitendra Badhai, Maarten van Lohuizen

Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer

亚型特异性激酶依赖性调节预后不良的间充质结直肠癌的生长和转移

Joyce Y Buikhuisen #, Patricia M Gomez Barila #, Kate Cameron, Saskia J E Suijkerbuijk, Cor Lieftink, Simone di Franco, Ana Krotenberg Garcia, Rebeca Uceda Castro, Kristiaan J Lenos, Lisanne E Nijman, Arezo Torang, Ciro Longobardi, Joan H de Jong, Daniëlle Dekker, Giorgio Stassi, Louis Vermeulen, Ro

Sustained activation of EGFR-ERK1/2 signaling limits the response to tigecycline-induced mitochondrial respiratory deficiency in liver cancer

EGFR-ERK1/2 信号的持续激活限制了肝癌对替加环素诱导的线粒体呼吸缺陷的反应

Yangyang Zhou, Siying Wang, Wei Wu, Jing Ling, Haoyu Li, Qi Jia, Jiaojiao Zheng, Xingling Zheng, Ruobing Yu, Qiangxin Wu, Yaoping Shi, Cor Lieftink, Roderick L Beijersbergen, Shengxian Yuan, René Bernards, Haojie Jin, Wenxin Qin