日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ageing promotes microglial accumulation of slow-degrading synaptic proteins.

衰老会促进小胶质细胞中缓慢降解的突触蛋白的积累。

Guldner Ian H, Wagner Viktoria P, Moran-Losada Patricia, Shi Sophia M, Golub Sophia W, Hevler Johannes F, Chen Kelly, Meese Barbara T, Ghoochani Ali, Pulido Ernst, Oh Hamilton Se-Hwee, Le Guen Yann, Lu Nannan, Wong Pui Shuen, To Ning-Sum, Garceau Dylan, Guo Zimin, Luo Jian, Bertozzi Carolyn R, Lundberg Emma, Abu-Remaileh Monther, Sasner Michael, Keller Andreas, Yang Andrew C, Cheung Tom H, Wyss-Coray Tony

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition.

针对老年大脑中的免疫细胞的研究表明,工程细胞因子 IL-10 可以增强神经发生并改善认知能力。

Navarro Negredo Paloma, You Justin, Hauptschein Max, Schroer Adam B, Richard Daniel J, Abhiraman Gita C, Tsai Andy P, Sun Eric D, Notarangelo Giulia, Ramirez-Matias Julliana, Zhou Olivia Y, Buckley Matthew T, Malacon Karen E, Xu Lucy, Sucharov Juliana, Ramirez Lopez Eduardo, Picton Lora, Wyss-Coray Tony, Saxton Robert A, Fernandes Ricardo A, Villeda Saul A, Garcia K Christopher, Brunet Anne

Simultaneous spatial transcriptomics and morphology profiling as tools to explore how microglia change with age.

同步空间转录组学和形态学分析作为探索小胶质细胞如何随年龄变化的工具。

Henze Douglas E, Tsai Andy P, Wyss-Coray Tony, Quake Stephen R

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish.

多组织转录组衰老图谱揭示了鳉鱼的预测性衰老生物标志物。

Costa Emma K, Chen Jingxun, Guldner Ian H, Mboning Lajoyce, Schmahl Natalie, Tsenter Aleksandra, Nagvekar Rahul, Wu Man-Ru, Moran-Losada Patricia, Bouchard Louis-S, Wang Sui, Singh Param Priya, Pellegrini Matteo, Brunet Anne, Wyss-Coray Tony

OMG! A proteomic determinant of neurodegenerative resiliency

我的天!神经退行性疾病恢复力的蛋白质组学决定因素

Duggan, Michael R; Oh, Hamilton Se-Hwee; Frank, Philipp; Gomez, Gabriela T; Zweibaum, David; Cui, Yuhan; Chen, Jingsha; Surapaneni, Aditya; Blew, Cassandra O; Dark, Heather E; Joynes, Cassandra M; Kandala, Sridhar; Bilgel, Murat; Farinas, Amelia; Erus, Guray; Tian, Qu; Candia, Julián; Pucha, Krishna A; Landman, Bennett A; Dumitrescu, Logan; Hohman, Timothy J; Lewis, Alexandria; Moghekar, Abhay; Siavoshi, Fatemeh; Ali, Muhammad; Liu, Menghan; Xu, Ying; Western, Daniel; Kaneko, Naoto; Kato, Shintaro; Furuichi, Makio; Shibayama, Masaki; Katsuno, Masahisa; Nishita, Yukiko; Otsuka, Rei; Gottesman, Rebecca F; Dammer, Eric B; Seyfried, Nicholas T; Levey, Allan I; B Johnson, Erik C; Mormino, Elizabeth; Wagner, Anthony D; Poston, Kathleen L; Kapogiannis, Dimitrios; Grams, Morgan E; Bhargava, Pavan; Waga, Iwao; Davatzikos, Christos; Resnick, Susan M; Ferrucci, Luigi; Bennett, David A; Cruchaga, Carlos; Wyss-Coray, Tony; Kivimäki, Mika; Coresh, Josef; Walker, Keenan A

PLCG2 signaling and genetic resilience in Alzheimer's disease

PLCG2信号传导与阿尔茨海默病中的遗传韧性

Tsai, Andy P; Martin, Amara K; Mi, Andrew; Yeh, Ava E; Ramirez Lopez, Eduardo; Wyss-Coray, Tony

MiRNAs shape mouse age-independent tissue adaptation to spaceflight via ECM and developmental pathways

miRNA通过ECM和发育途径影响小鼠与年龄无关的组织对太空飞行的适应性

Grandke, Friederike; Rishik, Shusruto; Wagner, Viktoria; Engel, Annika; Ludwig, Nicole; Calcuttawala, Kruti; Kern, Fabian; Keller, Verena; Krawczyk, Marcin; Stodieck, Louis; Ferguson, Virginia; Roberts, Amanda; Meese, Eckart; Schaum, Nicholas; Quake, Steven; Wyss-Coray, Tony; Keller, Andreas

In vivo CRISPR screening identifies SAGA complex members as key regulators of hematopoiesis.

体内 CRISPR 筛选鉴定出 SAGA 复合物成员是造血的关键调节因子。

Shankar Archana, Olender Leonid, Hsu Ian, Miyauchi Masashi, Pálovics Róbert, Meaker Grace A, Kaito Satoshi, Rizq Ola, Khoo Hwei Minn, Bozhilov Yavor, Igarashi Kyomi J, Bhadury Joydeep, Munson Christy, Mack Paul K, Tan Tze-Kai, Rehwinkel Jan, Iwama Atushi, Wyss-Coray Tony, Nakauchi Hiromitsu, Haney Michael S, Wilkinson Adam C

Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases

大规模脑脊液和血浆蛋白质组学分析揭示了神经退行性疾病中免疫、突触和细胞外基质的紊乱。

Ali, Muhammad; Timsina, Jigyasha; Xu, Ying; Chen, Yike; Gong, Katherine; Western, Daniel; Heo, Gyujin; Liu, Menghan; Budde, John; Pottier, Cyril; Schindler, Suzanne E; Morris, John C; Holtzman, David M; Puerta, Raquel; Cano, Amanda; Boada, Merce; Fernandez, Maria V; Ruiz, Agustin; Aguilar, Miquel; Alvarez, Ignacio; Pastor, Pau; Perlmutter, Joel S; Campbell, Meghan C; Kotzbauer, Paul T; Oh, Hamilton Se-Hwee; Wilson, Edward N; Guen, Yann Le; Tarawneh, Rawan; Wyss-Coray, Tony; Sung, Yun Ju; Ibanez, Laura; Cruchaga, Carlos

APOE-stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

基于APOE分层的蛋白质组学和代谢组学分析揭示了阿尔茨海默病中的线粒体功能障碍、炎症和脂质代谢紊乱

Li, Fuhai; Chen, Yike; Western, Daniel; Ali, Muhammad; Liu, Menghan; Gong, Katherine; Xu, Ying; Lowery, Joseph; Holtzman, David M; Robins, Chloe; Eicher, John D; Huang, Yen-Ning; Liu, ShiWei; Park, Tamina; Saykin, Andrew J; Nho, Kwangsik; Moqri, Mahdi; Mohs, Richard C; Farinas, Amelia; Moran-Losada, Patricia; Oh, Hamilton Se-Hwee; Wyss-Coray, Tony; Cruchaga, Carlos