日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease

靶向赖氨酰tRNA合成酶的抗锥虫喹唑啉类药物在急性恰加斯病小鼠模型中显示出部分疗效。

Tulloch, Lindsay B; Tawell, Hugh; Taylor, Annie E; Lima, Marta Lopes; Dawson, Alice; Carvalho, Sandra; Wall, Richard J; Corpas-Lopez, Victoriano; Dey, Gourav; Duggan, Jack; Magalhaes, Luma Godoy; Torrie, Leah S; Frame, Laura; Robinson, David; Patterson, Stephen; Tinti, Michele; Weaver, George W; Robinson, William J; Cal, Monica; Kaiser, Marcel; Mäser, Pascal; Sjö, Peter; Perry, Benjamin; Kelly, John M; Francisco, Amanda Fortes; Bhambra, Avninder S; Wyllie, Susan

Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1

杜氏利什曼原虫的甾醇 14-α 脱甲基酶 (CYP51) 活性可能依赖于细胞色素 P450 还原酶 1

Lindsay B Tulloch, Michele Tinti, Richard J Wall, Stefan K Weidt, Victoriano Corpas-Lopez, Gourav Dey, Terry K Smith, Alan H Fairlamb, Michael P Barrett, Susan Wyllie

Identification and Validation of Compounds Targeting Leishmania major Leucyl-Aminopeptidase M17

针对利什曼原虫亮氨酰氨基肽酶 M17 的化合物的鉴定和验证

Mirtha E Aguado, Sandra Carvalho, Mario E Valdés-Tresanco, De Lin, Norma Padilla-Mejia, Victoriano Corpas-Lopez, Martina Tesařová, Julius Lukeš, David Gray, Jorge González-Bacerio, Susan Wyllie, Mark C Field

Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation

强效酰基辅酶 A 合成酶 10 抑制剂通过破坏甘油三酯形成杀死恶性疟原虫

Selina Bopp, Charisse Flerida A Pasaje, Robert L Summers, Pamela Magistrado-Coxen, Kyra A Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S Nasamu, Allison R Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virgini

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues

2,4-二氨基噻唑系列药物的开发用于治疗非洲人类锥虫病,凸显了类似物静态杀灭筛选的重要性

Laura A T Cleghorn, Richard J Wall, Sébastien Albrecht, Stuart A MacGowan, Suzanne Norval, Manu De Rycker, Andrew Woodland, Daniel Spinks, Stephen Thompson, Stephen Patterson, Victoriano Corpas Lopez, Gourav Dey, Iain T Collie, Irene Hallyburton, Robert Kime, Frederick R C Simeons, Laste Stojanovski

Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium

作用方式研究证实了赖氨酰-tRNA 合成酶抑制剂的靶向作用,并为隐孢子虫提供了新的选择标记

Jack C Hanna, Victor Corpas-Lopez, Simona Seizova, Beatrice L Colon, Ross Bacchetti, Grant M J Hall, Emma M Sands, Lee Robinson, Beatriz Baragaña, Susan Wyllie, Mattie C Pawlowic

Chemical pulldown combined with mass spectrometry to identify the molecular targets of antimalarials in cell-free lysates

化学下拉法结合质谱分析鉴定无细胞裂解液中抗疟药物的分子靶点

Robert J Smith ,Rachel Milne ,Victoriano Corpas Lopez ,Natalie Wiedemar ,Gourav Dey ,Aisha J Syed ,Stephen Patterson ,Susan Wyllie

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

重新定位二氨基噻唑系列化合物,证实其靶向细胞周期蛋白依赖性激酶CRK12,可用于治疗非洲动物锥虫病

Smith, Alasdair; Wall, Richard J; Patterson, Stephen; Rowan, Tim; Rico Vidal, Eva; Stojanovski, Laste; Huggett, Margaret; Hampton, Shahienaz E; Thomas, Michael G; Corpas Lopez, Victoriano; Gillingwater, Kirsten; Duke, Jeff; Napier, Grant; Peter, Rose; Vitouley, Hervé S; Harrison, Justin R; Milne, Rachel; Jeacock, Laura; Baker, Nicola; Davis, Susan H; Simeons, Frederick; Riley, Jennifer; Horn, David; Brun, Reto; Zuccotto, Fabio; Witty, Michael J; Wyllie, Susan; Read, Kevin D; Gilbert, Ian H

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease

鉴定出一种可用于治疗恰加斯病的靶向蛋白酶体的芳基磺酰胺

Marta L Lima, Lindsay B Tulloch, Victoriano Corpas-Lopez, Sandra Carvalho, Richard J Wall, Rachel Milne, Eva Rico, Stephen Patterson, Ian H Gilbert, Sonia Moniz, Lorna MacLean, Leah S Torrie, Carmine Morgillo, David Horn, Fabio Zuccotto, Susan Wyllie

Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase

支持针对恶性疟原虫赖氨酰 tRNA 合成酶的靶向药物发现的方法工具包

Rachel Milne, Natalie Wiedemar, Victoriano Corpas-Lopez, Eoin Moynihan, Richard J Wall, Alice Dawson, David A Robinson, Sharon M Shepherd, Robert J Smith, Irene Hallyburton, John M Post, Karen Dowers, Leah S Torrie, Ian H Gilbert, Beatriz Baragaña, Stephen Patterson, Susan Wyllie