日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and mechanism of negative allosteric modulation of the α7 nicotinic acetylcholine receptor by nanobodies.

纳米抗体对α7尼古丁乙酰胆碱受体负变构调节的发现和机制。

Barilone Nathalie, Vangelatou Maria, Marouf F Zahra, Dejean de la Bâtie Gabrielle, Li Qimeng, Lafaye Pierre, Aymé Gabriel, Corringer Pierre-Jean, Prevost Marie S

The interpeduncular nucleus blunts the rewarding effect of nicotine.

脚间核减弱了尼古丁的奖赏效应

Jehl Joachim, Ciscato Maria, Vicq Eléonore, Guyon Nicolas, Dejean de la Batie Gabrielle, Mondoloni Sarah, Frangieh Jacinthe, Mohayyaei Monir, Nguyen Claire, Pons Stéphanie, Maskos Uwe, Hardelin Jean-Pierre, Marti Fabio, Corringer Pierre-Jean, Faure Philippe, Mourot Alexandre

A millisecond coarse-grained simulation approach to decipher allosteric cannabinoid binding at the glycine receptor α1

毫秒粗粒度模拟方法解释变构大麻素与甘氨酸受体 α1 的结合

Alessio Bartocci, Andrea Grazzi, Nour Awad, Pierre-Jean Corringer, Paulo C T Souza, Marco Cecchini

Mapping the molecular motions of 5-HT(3) serotonin-gated channel by voltage-clamp fluorometry

利用电压钳荧光法绘制5-HT(3)血清素门控通道的分子运动图谱

Peverini, Laurie; Shi, Sophie; Medjebeur, Karima; Corringer, Pierre-Jean

Short-chain mono-carboxylates as negative modulators of allosteric transitions in Gloeobacter violaceus ligand-gated ion channel, and impact of a pre-β5 strand (Loop Ω) double mutation on crotonate, not butyrate effect

短链单羧酸盐作为紫球杆菌配体门控离子通道变构转变的负调控剂,以及前β5链(Ω环)双突变对巴豆酸而非丁酸的影响

Van Renterghem, Catherine; Nemecz, Ákos; Medjebeur, Karima; Corringer, Pierre-Jean

Neutralizing Nanobodies against Venoms from Naja haje Species Captured in North Africa

中和纳米抗体对抗北非捕获的眼镜蛇毒液

Hiba Mejri, Rym Mokrani, Ayoub Ksouri, Mabrouk Seddik, Nour Awad, Gabriel Ayme, Thouraya Chagour, Ahlem Mokrani, Charraf Eddine Louchene, Imed Salhi, Rahma Ben Abderrazek, Rym Ben Khalifa, Zakaria Benlasfar, Pierre-Jean Corringer, Mohamed Hammadi, Selma Djilani, Pierre Lafaye, Balkiss Bouhaouala-Zah

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor

生成可作为α7尼古丁乙酰胆碱受体的沉默正向变构调节剂的纳米抗体

Li, Qimeng; Nemecz, Ákos; Aymé, Gabriel; Dejean de la Bâtie, Gabrielle; Prevost, Marie S; Pons, Stéphanie; Barilone, Nathalie; Baachaoui, Rayen; Maskos, Uwe; Lafaye, Pierre; Corringer, Pierre-Jean

Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway

甘氨酸受体胞外结构域的侧向窗孔是氯离子主要渗透途径的组成部分。

Cerdan, Adrien H; Peverini, Laurie; Changeux, Jean-Pierre; Corringer, Pierre-Jean; Cecchini, Marco

Conformational state-dependent regulation of GABAA receptor diffusion and subsynaptic domains

GABAA 受体扩散和突触下结构域的构象状态依赖性调节

Zaha Merlaud, Xavier Marques, Marion Russeau, Ursula Saade, Maelys Tostain, Imane Moutkine, Marc Gielen, Pierre-Jean Corringer, Sabine Lévi

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

突变分析探索涉及五聚体通道受体预激活和激活的长距离变构耦合

Solène N Lefebvre, Antoine Taly, Anaïs Menny, Karima Medjebeur, Pierre-Jean Corringer