日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

阿尔茨海默病海马 CA1 区神经元的自噬通量:诱导增加导致溶酶体负担过重,从而导致神经性营养不良

Matteo Bordi, Martin J Berg, Panaiyur S Mohan, Corrinne M Peterhoff, Melissa J Alldred, Shaoli Che, Stephen D Ginsberg, Ralph A Nixon

Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons

周围蛋白是周围神经丝的亚基:对中枢神经系统和周围神经系统轴突的差异脆弱性的影响

Aidong Yuan, Takahiro Sasaki, Asok Kumar, Corrinne M Peterhoff, Mala V Rao, Ronald K Liem, Jean-Pierre Julien, Ralph A Nixon

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

溶酶体蛋白水解和自噬需要早老素 1,而阿尔茨海默病相关的 PS1 突变会破坏这些过程

Ju-Hyun Lee, W Haung Yu, Asok Kumar, Sooyeon Lee, Panaiyur S Mohan, Corrinne M Peterhoff, Devin M Wolfe, Marta Martinez-Vicente, Ashish C Massey, Guy Sovak, Yasuo Uchiyama, David Westaway, Ana Maria Cuervo, Ralph A Nixon

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition

唐氏综合征中与阿尔茨海默病相关的内体功能障碍与 Abeta 无关,但需要 APP,并且可通过 BACE-1 抑制逆转

Ying Jiang, Kerry A Mullaney, Corrinne M Peterhoff, Shaoli Che, Stephen D Schmidt, Anne Boyer-Boiteau, Stephen D Ginsberg, Anne M Cataldo, Paul M Mathews, Ralph A Nixon

Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects

唐氏综合征成纤维细胞与阿尔茨海默病相关的内体病理模型:加速内吞作用促进晚期内吞缺陷

Anne M Cataldo, Paul M Mathews, Anne Boyer Boiteau, Linda C Hassinger, Corrinne M Peterhoff, Ying Jiang, Kerry Mullaney, Rachael L Neve, Jean Gruenberg, Ralph A Nixon