日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Population-scale gene-based analysis of whole-genome sequencing provides insights into metabolic health

基于全基因组测序的群体规模基因分析能够深入了解代谢健康。

Zhao, Yajie; Lockhart, Sam; Liu, Jimmy; Li, Xihao; Cortes, Adrian; Hua, Xing; Gardner, Eugene J; Kentistou, Katherine A; Cañadas-Garre, Marisa; Fabian, Laurie; Ho, Karen; Timpson, Nicholas; Lo, Yancy; Davitte, Jonathan; Savage, David B; Buser-Doepner, Carolyn; Ong, Ken K; Zhang, Haoyu; Scott, Robert; O'Rahilly, Stephen; Perry, John R B

Evaluating transportability of in vitro cellular models to in vivo human phenotypes using gene perturbation data

利用基因扰动数据评估体外细胞模型向体内人类表型的可移植性

Howe, Laurence J; Aulchenko, Yurii S; Davey Smith, George; Davies, Neil M; Esparza-Gordillo, Jorge; Johnson, Toby; Liu, Jimmy Z; Richardson, Tom G; Sanseau, Philippe; Scott, Robert A; Seaton, Daniel D; Sharma, Ashwini; Cortes, Adrian

A computational framework for defining and validating reproducible phenotyping algorithms of 313 diseases in the UK Biobank

用于定义和验证英国生物银行中313种疾病可重复表型分析算法的计算框架

Torralbo, Ana; Davitte, Jonathan M; Croteau-Chonka, Damien C; Ytsma, Cai; Tomlinson, Chris; Fitzpatrick, Natalie K; Chung, Sheng-Chia; Fatemifar, Ghazaleh; Cortes, Adrian S; Richardson, Tom G; Barclay, Matthew; Carrasco-Zanini, Julia; Finan, Chris; Hemingway, Harry; Hingorani, Aroon D; Kuan, Valerie; Langenberg, Claudia; Lyratzopoulos, Georgios; Lumbers, R Thomas; Pietzner, Maik; Shah, Anoop D; Thygesen, Johan H; Zelenka, Natalie; Whittaker, John C; Ehm, Margaret G; Denaxas, Spiros

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy

英国生物银行抗体分析检测到的一种常见NFKB1变异体可预测感染和过敏风险

Chong, Amanda Y; Brenner, Nicole; Jimenez-Kaufmann, Andres; Cortes, Adrian; Hill, Michael; Littlejohns, Thomas J; Gilchrist, James J; Fairfax, Benjamin P; Knight, Julian C; Hodel, Flavia; Fellay, Jacques; McVean, Gil; Moreno-Estrada, Andres; Waterboer, Tim; Hill, Adrian V S; Mentzer, Alexander J

Small-cohort GWAS discovery with AI over massive functional genomics knowledge graph

利用人工智能技术,基于海量功能基因组学知识图谱,开展小样本GWAS发现研究。

Huang, Kexin; Zeng, Tony; Koc, Soner; Pettet, Alexandra; Zhou, Jingtian; Jain, Mika; Sun, Dongbo; Ruiz, Camilo; Ren, Hongyu; Howe, Laurence; Richardson, Tom G; Cortes, Adrian; Aiello, Katie; Branson, Kim; Pfenning, Andreas; Engreitz, Jesse M; Zhang, Martin Jinye; Leskovec, Jure

Identification of host-pathogen-disease relationships using a scalable multiplex serology platform in UK Biobank

利用英国生物银行中可扩展的多重血清学平台识别宿主-病原体-疾病关系

Mentzer, Alexander J; Brenner, Nicole; Allen, Naomi; Littlejohns, Thomas J; Chong, Amanda Y; Cortes, Adrian; Almond, Rachael; Hill, Michael; Sheard, Simon; McVean, Gil; Collins, Rory; Hill, Adrian V S; Waterboer, Tim

Mapping the proteo-genomic convergence of human diseases

绘制人类疾病的蛋白质组-基因组融合图谱

Pietzner, Maik; Wheeler, Eleanor; Carrasco-Zanini, Julia; Cortes, Adrian; Koprulu, Mine; Wörheide, Maria A; Oerton, Erin; Cook, James; Stewart, Isobel D; Kerrison, Nicola D; Luan, Jian'an; Raffler, Johannes; Arnold, Matthias; Arlt, Wiebke; O'Rahilly, Stephen; Kastenmüller, Gabi; Gamazon, Eric R; Hingorani, Aroon D; Scott, Robert A; Wareham, Nicholas J; Langenberg, Claudia

Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties.

内质网氨肽酶 1 的常见同种异型具有底物依赖性和高度可变的酶学特性

Hutchinson Jonathan P, Temponeras Ioannis, Kuiper Jonas, Cortes Adrian, Korczynska Justyna, Kitchen Semra, Stratikos Efstratios

Identifying cross-disease components of genetic risk across hospital data in the UK Biobank

利用英国生物银行的医院数据识别遗传风险的跨疾病成分

Cortes, Adrian; Albers, Patrick K; Dendrou, Calliope A; Fugger, Lars; McVean, Gil

MHC associations of ankylosing spondylitis in East Asians are complex and involve non-HLA-B27 HLA contributions

东亚人群强直性脊柱炎的MHC关联性复杂,涉及非HLA-B27 HLA的贡献。

Wang, Geng; Kim, Tae-Hwan; Li, Zhixiu; Cortes, Adrian; Kim, Kwangwoo; Bang, So-Young; Leo, Paul; Brown, Matthew A; Xu, Huji