日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Smac mimetic combined with eCD4-Ig reverses latency without reducing SHIV reservoirs in rhesus macaques

Smac 模拟物与 eCD4-Ig 联合使用可逆转恒河猴的潜伏感染,且不减少 SHIV 病毒库。

Pache, Lars; Bui, John K; Klouser, Lindsay M; Fennessey, Christine M; Noyola, Alexander C; Einhaus, Teresa; Zhu, Haiying; Stensland, Laurence; Leguizamo, Isai; Koroma, Abubakarr A; Teriete, Peter; Chang, W L William; Hyrien, Ollivier; Duggan, Natasha N; Heimann, Dominik; Pérez-Osorio, Ailyn C; Bar, Katharine J; Cosford, Nicholas Dp; Keele, Brandon F; Hartigan-O'Connor, Dennis J; Farzan, Michael; Gardner, Matthew R; Jerome, Keith R; Chanda, Sumit K; Kiem, Hans-Peter; Peterson, Christopher W

Erratum to "Spontaneous daily sleep disruptions associated with morphine dependence and withdrawal in rats" [The Journal of Pharmacology and Experimental Therapeutics 392 (2025) 103766]

对“与吗啡依赖和戒断相关的自发性日常睡眠紊乱在大鼠中”的勘误[药理学和实验治疗学杂志 392 (2025) 103766]

McKelvey, Harlie A; Pierce, Bethany E; Lynch, Jesse M; Kim, Audrey L; Holter, Kimberly M; Gadient, Reto A; Sheffler, Douglas J; Velicelebi, Gonul; Cosford, Nicholas D P; Gould, Robert W

17β-estradiol status alters NMDAR function and antipsychotic-like activity in female rats

17β-雌二醇水平改变雌性大鼠的NMDAR功能和抗精神病样活性

Holter, Kimberly M; Klausner, McKenna G; Hite, Mary Hunter; Moriarty, Carson T; Barth, Samuel H; Pierce, Bethany E; Iannucci, Alexandria N; Sheffler, Douglas J; Cosford, Nicholas D P; Bimonte-Nelson, Heather A; Raab-Graham, Kimberly F; Gould, Robert W

Spontaneous daily sleep disruptions associated with morphine dependence and withdrawal in rats

大鼠吗啡依赖和戒断相关的自发性每日睡眠紊乱

McKelvey, Harlie A; Pierce, Bethany E; Lynch, Jesse M; Kim, Audrey L; Holter, Kimberly M; Gadient, Reto A; Sheffler, Douglas J; Velicelebi, Gonul; Cosford, Nicholas D P; Gould, Robert W

Synthesis and Characterization of ULK1/2 Kinase Inhibitors that Inhibit Autophagy and Upregulate Expression of Major Histocompatibility Complex I for the Treatment of Non-Small Cell Lung Cancer

合成和表征抑制自噬并上调主要组织相容性复合体I表达的ULK1/2激酶抑制剂,用于治疗非小细胞肺癌

Layng, Fabiana Izidro A L; Ren, Huiyu; Bakas, Nicole A; Panickar, Dhanya R; Lambert, Lester J; Celeridad, Maria; Wu, Jiaqian; De Backer, Laurent; Chandrachud, Preeti; Limpert, Allison S; Vamos, Mitchell; Chaikuad, Apirat; Verdugo, Betsaida B; Hagan, Patrick M; Brun, Sonja N; Tautz, Lutz; Knapp, Stefan; Shaw, Reuben J; Salvesen, Guy S; Sheffler, Douglas J; Cosford, Nicholas D P

ULK1/2 Inhibitors that Degrade ATG13 Effectively Target KRAS-Mutant Cancers

能有效降解ATG13的ULK1/2抑制剂可靶向KRAS突变型癌症

Hagan, Patrick M; Ren, Huiyu; Brun, Sonja N; Layng, Fabiana I A; Panickar, Dhanya R; Lambert, Lester J; Celeridad, Maria; Das, Ranajit; Ling, Li; Zhang, Yijuan; Limpert, Allison S; Sheffler, Douglas J; Commisso, Cosimo; Shaw, Reuben J; Cosford, Nicholas D P

Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer

利用自噬和嘧啶代谢靶向治疗胰腺癌

Dufresne, Suzanne; Kuna, Ramya S; Wong, Kristiana; Komarla, Anvita; Rock, Angelica; Rosada-Encarnación, Joel; Shen, Celina; Mondal, Payel; Parham, Louis R; Izidro Layng, Fabiana; Peck, Kristina L; Fowler, Alexandra; Lowy, Andrew M; Engle, Dannielle; Tiriac, Herve; Shaw, Reuben; Cosford, Nicholas; Metallo, Christian; Towers, Christina

Radiosynthesis and preclinical evaluation of a carbon-11 labeled PET ligand for imaging metabotropic glutamate receptor 7

碳-11标记PET配体的放射合成及临床前评估用于代谢型谷氨酸受体7的成像

Li, Yinlong; Xiao, Zhiwei; Mori, Wakana; Sun, Jiyun; Yamasaki, Tomoteru; Rong, Jian; Fujinaga, Masayuki; Chen, Jiahui; Kumata, Katsushi; Zhao, Chunyu; Zhang, Yiding; Collier, Thomas L; Hu, Kuan; Xie, Lin; Zhou, Xin; Zhang, Wei; Song, Zhendong; Gao, Yabiao; Sun, Zhenkun; Zhang, Kuo; Patel, Jimmy S; Ran, Chongzhao; Chaudhary, Ahmad; Sheffler, Douglas J; Cosford, Nicholas Dp; Zhang, Linqi; Zhai, Chuangyan; Haider, Ahmed; Yuan, Hongjie; Zhang, Ming-Rong; Liang, Steven H

Detection of Cellular Target Engagement for Small-Molecule Modulators of Striatal-Enriched Protein Tyrosine Phosphatase (STEP)

检测纹状体富集蛋白酪氨酸磷酸酶 (STEP) 小分子调节剂的细胞靶标结合情况

Han, Ye Na; Lambert, Lester J; De Backer, Laurent J S; Wu, Jiaqian; Cosford, Nicholas D P; Tautz, Lutz

Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo

新型强效氮杂环丁烷类化合物可不可逆地抑制Stat3活化,并在体内诱导抗肿瘤反应,抑制人乳腺肿瘤生长。

Yue, Peibin; Zhu, Yinsong; Brotherton-Pleiss, Christine; Fu, Wenzhen; Verma, Nagendra; Chen, Jasmine; Nakamura, Kayo; Chen, Weiliang; Chen, Yue; Alonso-Valenteen, Felix; Mikhael, Simoun; Medina-Kauwe, Lali; Kershaw, Kathleen M; Celeridad, Maria; Pan, Songqin; Limpert, Allison S; Sheffler, Douglas J; Cosford, Nicholas D P; Shiao, Stephen L; Tius, Marcus A; Lopez-Tapia, Francisco; Turkson, James