日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Respiratory viral infections awaken metastatic breast cancer cells in lungs.

呼吸道病毒感染会激活肺部转移性乳腺癌细胞

Chia Shi B, Johnson Bryan J, Hu Junxiao, Valença-Pereira Felipe, Chadeau-Hyam Marc, Guntoro Fernando, Montgomery Hugh, Boorgula Meher P, Sreekanth Varsha, Goodspeed Andrew, Davenport Bennett, De Dominici Marco, Zaberezhnyy Vadym, Schleicher Wolfgang E, Gao Dexiang, Cadar Andreia N, Petriz-Otaño Lucia, Papanicolaou Michael, Beheshti Afshin, Baylin Stephen B, Guarnieri Joseph W, Wallace Douglas C, Costello James C, Bartley Jenna M, Morrison Thomas E, Vermeulen Roel, Aguirre-Ghiso Julio A, Rincon Mercedes, DeGregori James

eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by small molecules.

eIF3d 和 eIF3e 介导对缺氧的选择性翻译控制,这种控制可被小分子抑制。

Purdy Stephen C, Matlin Kate, Alderman Christopher, Baldwin Amber, Shrivastava Natasha, Sarioglu Goksu, Dutta Somnath, Webb Kristofor J, Wolin Arthur, Boulton Dillon P, Gustafson Annika, Kapali Jyoti, Landua John D, Lewis Michael T, Caino M Cecilia, Costello James C, Old William, Wang Xiang, Zhao Rui, Ford Heide L, Mukherjee Neelanjan

Editorial: State-of-the-art hypothesis-driven systems pharmacology and artificial intelligence approaches to decipher disease complexity

社论:运用最先进的假设驱动系统药理学和人工智能方法解读疾病复杂性

Correia, Cristina; Ung, Choong-Yong; Li, Hu; Costello, James C

A Roadmap for the Future of Systems Biology in Cancer Research

癌症研究中系统生物学未来发展路线图

Wiley, H Steven; Lopez, Carlos F; Rodin, Andrei S; Rockne, Russell C; Yankeelov, Thomas E; Sauro, Herbert M; Hassan, Ghmkin; Prabhakaran, Sandhya; Demir, Emek; Hu, Mengzhou; Fuxman Bass, Juan; Luddy, Kimberly A; Newman, Hannah; Mochel, Jonathan P; Costello, James C; Xing, Jianhua; Afify, Said M; Acar, Ahmet; Haden Gephart, Melanie; Feng, Song; Banks, Orion; Banerjee, Jineta; Clayton, Ashley; Hill, David E; Sweis, Randy F; Umeh-Garcia, Maxine C; Su, Yapeng; Meyer, Aaron S

eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by novel small molecules.

eIF3d 和 eIF3e 介导对缺氧的选择性翻译控制,这种控制可被新型小分子抑制

Purdy Stephen C, Matlin Kate, Alderman Christopher, Baldwin Amber, Shrivastava Natasha, Dutta Somnath, Webb Kristofor J, Wolin Arthur, Boulton Dillon P, Kapali Jyoti, Landua John D, Lewis Michael T, Caino M Cecilia, Costello James C, Old William, Wang Xiang, Zhao Rui, Ford Heide L, Mukherjee Neelanjan

ProstaMine: a bioinformatics tool for identifying subtype-specific co-alterations associated with aggressiveness in prostate cancer

ProstaMine:一种用于识别与前列腺癌侵袭性相关的亚型特异性共改变的生物信息学工具

Orman, Michael V; Sreekanth, Varsha; Laajala, Teemu D; Cramer, Scott D; Costello, James C

Microbiome Preterm Birth DREAM Challenge: Crowdsourcing Machine Learning Approaches to Advance Preterm Birth Research

微生物组早产梦想挑战:利用众包机器学习方法推进早产研究

Golob, Jonathan L; Oskotsky, Tomiko T; Tang, Alice S; Roldan, Alennie; Chung, Verena; Ha, Connie W Y; Wong, Ronald J; Flynn, Kaitlin J; Parraga-Leo, Antonio; Wibrand, Camilla; Minot, Samuel S; Andreoletti, Gaia; Kosti, Idit; Bletz, Julie; Nelson, Amber; Gao, Jifan; Wei, Zhoujingpeng; Chen, Guanhua; Tang, Zheng-Zheng; Novielli, Pierfrancesco; Romano, Donato; Pantaleo, Ester; Amoroso, Nicola; Monaco, Alfonso; Vacca, Mirco; De Angelis, Maria; Bellotti, Roberto; Tangaro, Sabina; Kuntzleman, Abigail; Bigcraft, Isaac; Techtmann, Stephen; Bae, Daehun; Kim, Eunyoung; Jeon, Jongbum; Joe, Soobok; Theis, Kevin R; Ng, Sherrianne; Lee Li, Yun S; Diaz-Gimeno, Patricia; Bennett, Phillip R; MacIntyre, David A; Stolovitzky, Gustavo; Lynch, Susan V; Albrecht, Jake; Gomez-Lopez, Nardhy; Romero, Roberto; Stevenson, David K; Aghaeepour, Nima; Tarca, Adi L; Costello, James C; Sirota, Marina

A Crowdsourcing Approach to Develop Machine Learning Models to Quantify Radiographic Joint Damage in Rheumatoid Arthritis

利用众包方法开发机器学习模型,以量化类风湿性关节炎的放射学关节损伤

Sun, Dongmei; Nguyen, Thanh M; Allaway, Robert J; Wang, Jelai; Chung, Verena; Yu, Thomas V; Mason, Michael; Dimitrovsky, Isaac; Ericson, Lars; Li, Hongyang; Guan, Yuanfang; Israel, Ariel; Olar, Alex; Pataki, Balint Armin; Stolovitzky, Gustavo; Guinney, Justin; Gulko, Percio S; Frazier, Mason B; Chen, Jake Y; Costello, James C; Bridges, S Louis Jr

SOPHIE: Generative Neural Networks Separate Common and Specific Transcriptional Responses

SOPHIE:生成式神经网络区分常见和特异性转录反应

Lee, Alexandra J; Mould, Dallas L; Crawford, Jake; Hu, Dongbo; Powers, Rani K; Doing, Georgia; Costello, James C; Hogan, Deborah A; Greene, Casey S

A Whole-genome CRISPR Screen Identifies a Role of MSH2 in Cisplatin-mediated Cell Death in Muscle-invasive Bladder Cancer

全基因组 CRISPR 筛选揭示 MSH2 在顺铂介导的肌层浸润性膀胱癌细胞死亡中的作用

Goodspeed, Andrew; Jean, Annie; Costello, James C