日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A fission yeast-based platform for nematode PDE inhibitor discovery

基于裂殖酵母的线虫PDE抑制剂发现平台

Bibeau, Sarah; Chen, Natalie; Sutoris, Hannah; Ly, Judy; Eberhard, Jeremy; Hubbell, Sara M; Banda, Eric; Povh, Esther; Anindya, Clianta S; Berwanger, Michael R; Sinise, Sarah E; Zhang, Xieyang; Morken, James P; Galande, Kranti K; Cote, Rick H; Dranchak, Patricia K; Inglese, James; Hoffman, Charles S

Cyclic nucleotide phosphodiesterases as drug targets

环核苷酸磷酸二酯酶作为药物靶点

Kelly, Michy P; Nikolaev, Viacheslav O; Gobejishvili, Leila; Lugnier, Claire; Hesslinger, Christian; Nickolaus, Peter; Kass, David A; Pereira de Vasconcelos, Walma; Fischmeister, Rodolphe; Brocke, Stefan; Epstein, Paul M; Piazza, Gary A; Keeton, Adam B; Zhou, Gang; Abdel-Halim, Mohammad; Abadi, Ashraf H; Baillie, George S; Giembycz, Mark A; Bolger, Graeme; Snyder, Gretchen; Tasken, Kjetil; Saidu, Nathaniel E B; Schmidt, Martina; Zaccolo, Manuela; Schermuly, Ralph T; Ke, Hengming; Cote, Rick H; Mohammadi Jouabadi, Soroush; Roks, Anton J M

Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the Nematode Caenorhabditis elegans

环核苷酸磷酸二酯酶在秀丽隐杆线虫信号转导通路中的作用

Galande, Kranti K; Cote, Rick H

Coupling of conformational dynamics and inhibitor binding in the phosphodiesterase-5 family

磷酸二酯酶-5家族中构象动力学与抑制剂结合的耦合

Tripathi, Shubhandra; Cote, Rick H; Vashisth, Harish

Photoreceptor Phosphodiesterase (PDE6): Structure, Regulatory Mechanisms, and Implications for Treatment of Retinal Diseases

视网膜感光细胞磷酸二酯酶(PDE6):结构、调控机制及其在视网膜疾病治疗中的意义

Cote, Rick H; Gupta, Richa; Irwin, Michael J; Wang, Xin

Photoreceptor phosphodiesterase (PDE6): activation and inactivation mechanisms during visual transduction in rods and cones

感光细胞磷酸二酯酶(PDE6):视杆细胞和视锥细胞视觉转导过程中的激活和失活机制

Cote, Rick H

Pharmacological and molecular dynamics analyses of differences in inhibitor binding to human and nematode PDE4: Implications for management of parasitic nematodes.

抑制剂与人类和线虫 PDE4 结合差异的药理学和分子动力学分析:对寄生线虫管理的影响

Schuster Kevin D, Mohammadi Mohammadjavad, Cahill Karyn B, Matte Suzanne L, Maillet Alexis D, Vashisth Harish, Cote Rick H

Functional mapping of interacting regions of the photoreceptor phosphodiesterase (PDE6) γ-subunit with PDE6 catalytic dimer, transducin, and regulator of G-protein signaling9-1 (RGS9-1)

光感受器磷酸二酯酶 (PDE6) γ 亚基与 PDE6 催化二聚体、转导蛋白和 G 蛋白信号调节因子 9-1 (RGS9-1) 相互作用区域的功能映射

Zhang, Xiu-Jun; Gao, Xiong-Zhuo; Yao, Wei; Cote, Rick H

Evaluation of the 17-kDa prenyl-binding protein as a regulatory protein for phototransduction in retinal photoreceptors

评估 17 kDa 异戊二烯结合蛋白作为视网膜光感受器光转导调节蛋白的作用

Norton, Angela W; Hosier, Suzanne; Terew, Jennifer M; Li, Ning; Dhingra, Anuradha; Vardi, Noga; Baehr, Wolfgang; Cote, Rick H