日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Therapeutic potential of allosteric HECT E3 ligase inhibition.

变构 HECT E3 连接酶抑制的治疗潜力

Rothman Alexander M K, Florentin Amir, Zink Florence, Quigley Catherine, Bonneau Olivier, Hemmig Rene, Hachey Amanda, Rejtar Tomas, Thaker Maulik, Jain Rishi, Huang Shih-Min, Sutton Daniel, Roger Jan, Zhang Ji-Hu, Weiler Sven, Cotesta Simona, Ottl Johannes, Srivastava Salil, Kordonsky Alina, Avishid Reut, Yariv Elon, Rathi Ritu, Khvalevsky Oshrit, Troxler Thomas, Binmahfooz Sarah K, Kleifeld Oded, Morrell Nicholas W, Humbert Marc, Thomas Matthew J, Jarai Gabor, Beckwith Rohan E J, Cobb Jennifer S, Smith Nichola, Ostermann Nils, Tallarico John, Shaw Duncan, Guth-Gundel Sabine, Prag Gali, Rowlands David J

Identification and characterization of binders to a cryptic and functional pocket in KRAS

鉴定和表征KRAS中隐蔽功能口袋的结合蛋白

Beyer, Kim S; Klein, Jessica; Katz, Stéphanie; Welker, Patrick; Lanter, Mylene; Guthy, Daniel; Pollehn, Kerstin; Gluck-Gadé, Aurélie; Bleu, Melusine; Desogus, Jessica; Hattenberger, Marc; Borrello, Damiano; Abdul Rahman, Wassim; Zink, Florence; Ostermann, Nils; Jahnke, Wolfgang; Dumelin, Christoph E; Leder, Lukas; Esser, Oliver; Muller, Lionel; Marzinzik, Andreas; Cébé, Regis; Müller, Kathrin; Galli, Giorgio G; Tordella, Luca; Cotesta, Simona; Brachmann, Saskia M; Maira, Sauveur-Michel

Dynamic conformational equilibria in the active states of KRAS and NRAS

KRAS和NRAS活性状态下的动态构象平衡

Rennella, Enrico; Henry, Chrystèle; Dickson, Callum J; Georgescauld, Florian; Wales, Thomas E; Erdmann, Dirk; Cotesta, Simona; Maira, Michel; Sedrani, Richard; Brachmann, Saskia M; Ostermann, Nils; Engen, John R; Kay, Lewis E; Beyer, Kim S; Wilcken, Rainer; Jahnke, Wolfgang

Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin

真菌次级代谢产物枝孢素对恶性疟原虫赖氨酰tRNA合成酶的选择性和特异性抑制作用

Hoepfner, Dominic; McNamara, Case W; Lim, Chek Shik; Studer, Christian; Riedl, Ralph; Aust, Thomas; McCormack, Susan L; Plouffe, David M; Meister, Stephan; Schuierer, Sven; Plikat, Uwe; Hartmann, Nicole; Staedtler, Frank; Cotesta, Simona; Schmitt, Esther K; Petersen, Frank; Supek, Frantisek; Glynne, Richard J; Tallarico, John A; Porter, Jeffrey A; Fishman, Mark C; Bodenreider, Christophe; Diagana, Thierry T; Movva, N Rao; Winzeler, Elizabeth A

Dynamics of RNase-A and S-protein: a molecular dynamics simulation of the transition toward a folding intermediate

RNase-A 和 S 蛋白的动力学:向折叠中间体转变的分子动力学模拟

Cotesta, Simona; Tavernelli, Ivano; Di Iorio, Ernesto E