日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Co-Delivery of a Novel Lipidated TLR7/8 Agonist and Hemagglutinin-Based Influenza Antigen Using Silica Nanoparticles Promotes Enhanced Immune Responses.

利用二氧化硅纳米颗粒共同递送新型脂化 TLR7/8 激动剂和基于血凝素的流感抗原可促进增强免疫反应

Abdelwahab Walid M, Auclair Sarah, Borgogna Timothy, Siram Karthik, Riffey Alexander, Bazin Hélène G, Cottam Howard B, Hayashi Tomoko, Evans Jay T, Burkhart David J

Identification of a Novel Small Molecule That Enhances the Release of Extracellular Vesicles with Immunostimulatory Potency via Induction of Calcium Influx

鉴定一种新型小分子,该小分子通过诱导钙离子内流增强具有免疫刺激活性的细胞外囊泡的释放

Sako, Yukiya; Sato-Kaneko, Fumi; Shukla, Nikunj M; Yao, Shiyin; Belsuzarri, Masiel M; Chan, Michael; Saito, Tetsuya; Lao, Fitzgerald S; Kong, Helen; Puffer, Marina; Messer, Karen; Pu, Minya; Cottam, Howard B; Carson, Dennis A; Hayashi, Tomoko

Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice

合成的 Toll 样受体 4 (TLR4) 和 TLR7 配体通过 MyD88 发挥叠加作用,诱导小鼠产生保护性抗病毒免疫力

Goff, Peter H; Hayashi, Tomoko; He, Wenqian; Yao, Shiyin; Cottam, Howard B; Tan, Gene S; Crain, Brian; Krammer, Florian; Messer, Karen; Pu, Minya; Carson, Dennis A; Palese, Peter; Corr, Maripat

Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands

发现取代的4-氨基喹唑啉类化合物作为选择性Toll样受体4配体

Nour, Afshin; Hayashi, Tomoko; Chan, Michael; Yao, Shiyin; Tawatao, Rommel I; Crain, Brian; Tsigelny, Igor F; Kouznetsova, Valentina L; Ahmadiiveli, Alast; Messer, Karen; Pu, Minya; Corr, Maripat; Carson, Dennis A; Cottam, Howard B

Implementing fluorescence anisotropy screening and crystallographic analysis to define PKA isoform-selective activation by cAMP analogs

运用荧光各向异性筛选和晶体学分析来确定cAMP类似物对PKA亚型的选择性激活作用

Brown, Simon H J; Cheng, Cecilia Y; Saldanha, S Adrian; Wu, Jian; Cottam, Howard B; Sankaran, Banumathi; Taylor, Susan S

Synthesis and characterization of PEGylated toll like receptor 7 ligands

聚乙二醇化Toll样受体7配体的合成与表征

Chan, Michael; Hayashi, Tomoko; Mathewson, Richard D; Yao, Shiyin; Gray, Christine; Tawatao, Rommel I; Kalenian, Kevin; Zhang, Yanmei; Hayashi, Yuki; Lao, Fitzgerald S; Cottam, Howard B; Carson, Dennis A

Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2

病灶内注射磷脂偶联的TLR7激动剂和全身性IL-2可增强黑色素瘤抑制作用

Hayashi, Tomoko; Chan, Michael; Norton, John T; Wu, Christina C N; Yao, Shiyin; Cottam, Howard B; Tawatao, Rommel I; Corr, Maripat; Carson, Dennis A; Daniels, Gregory A

Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates

Toll样受体7激动剂缀合物的合成及免疫学表征

Chan, Michael; Hayashi, Tomoko; Kuy, Crystal S; Gray, Christine S; Wu, Christina C N; Corr, Maripat; Wrasidlo, Wolfgang; Cottam, Howard B; Carson, Dennis A

Amide derivatives of ethacrynic acid: synthesis and evaluation as antagonists of Wnt/beta-catenin signaling and CLL cell survival

依他尼酸酰胺衍生物:合成及其作为Wnt/β-catenin信号通路拮抗剂和CLL细胞存活的评价

Jin, Guangyi; Lu, Desheng; Yao, Shiyin; Wu, Christina C N; Liu, Jerry X; Carson, Dennis A; Cottam, Howard B

BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway

BAFF 和 APRIL 通过激活经典的 NF-κB 通路来促进慢性淋巴细胞白血病 B 细胞的存活。

Endo, Tomoyuki; Nishio, Mitsufumi; Enzler, Thomas; Cottam, Howard B; Fukuda, Tetsuya; James, Danelle F; Karin, Michael; Kipps, Thomas J