文献库，生知库 | 链接生命科学的每一步

日期影响因子

Differences in blood levels of neuroligin-derived peptides in a cohort for early detection of Alzheimer's disease

阿尔茨海默病早期检测队列中神经连接蛋白衍生肽血液水平的差异

doi:10.1093/gerona/glag009

Fernandes, Milton G F; Pinard, Maxime; Sokullu, Esen; Tremblay, Cyntia; Gagnon, Jean-François; Calon, Frédéric; Coulombe, Benoit; Brouillette, Jonathan

阿尔茨海默症

发表日期：2026

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Neuroligin fragments as blood‐based biomarkers for early detection of Alzheimer's disease

神经连接蛋白片段作为血液生物标志物用于阿尔茨海默病早期检测

期刊:Journal of Neuroscience

doi:10.1523/JNEUROSCI.1288-24.2025

Marmelshtein, Amit; Lavy, Barak; Hadad, Barak; Nir, Yuval; Gramkow, Mathias Holsey; Clemmensen, Frederikke Kragh; Brink‐Kjær, Andreas; Lindberg, Ulrich; Law, Ian; Henriksen, Otto Mølby; Waldemar, Gunhild; Jennum, Poul Jørgen; Hasselbalch, Steen G; Frederiksen, Kristian Steen; Fernandes, Milton Guilherme Forestieri; Pinard, Maxime; Sokullu, Esen; Gagnon, Jean‐François; Calon, Frederic; Coulombe, Benoit; Brouillette, Jonathan

阿尔茨海默症

发表日期：2025

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AI-Powered Identification of Human Cell Surface Protein Interactors of the Hemagglutinin Glycoprotein of High-Pandemic-Risk H5N1 Influenza Virus

利用人工智能技术鉴定高危H5N1禽流感病毒血凝素糖蛋白的人类细胞表面蛋白相互作用蛋白

期刊:Viruses-Basel

影响因子:3.5

doi:10.3390/v17121638

Poitras, Christian; Coulombe, Benoit

细胞生物学

发表日期：2025

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Towards a Treatment for Leukodystrophy Using Cell-Based Interception and Precision Medicine

利用细胞拦截和精准医学治疗脑白质营养不良症

期刊:Biomolecules

影响因子:4.8

doi:10.3390/biom14070857

Coulombe, Benoit; Chapleau, Alexandra; Macintosh, Julia; Durcan, Thomas M; Poitras, Christian; Moursli, Yena A; Faubert, Denis; Pinard, Maxime; Bernard, Geneviève

细胞生物学

发表日期：2024

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The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases

旨在通过细胞拦截和精准医疗改善全球医疗保健的“37万亿细胞”计划：重点关注神经退行性疾病

期刊:Molecular Brain

影响因子:2.9

doi:10.1186/s13041-024-01088-4

Coulombe, Benoit; Durcan, Thomas M; Bernard, Geneviève; Moursli, Asmae; Poitras, Christian; Faubert, Denis; Pinard, Maxime

细胞生物学

发表日期：2024

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Hypomyelination, hypodontia and craniofacial abnormalities in a Polr3b mouse model of leukodystrophy

Polr3b小鼠脑白质营养不良模型中的髓鞘形成不足、牙齿缺失和颅面畸形

影响因子:11.7

doi:10.1093/brain/awad249

Michell-Robinson, Mackenzie A; Watt, Kristin E N; Grouza, Vladimir; Macintosh, Julia; Pinard, Maxime; Tuznik, Marius; Chen, Xiaoru; Darbelli, Lama; Wu, Chia-Lun; Perrier, Stefanie; Chitsaz, Daryan; Uccelli, Nonthué A; Liu, Hanwen; Cox, Timothy C; Müller, Christoph W; Kennedy, Timothy E; Coulombe, Benoit; Rudko, David A; Trainor, Paul A; Bernard, Geneviève

发表日期：2023

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Biallelic pathogenic variants in POLR3D alter tRNA transcription and cause a hypomyelinating leukodystrophy: A case report

POLR3D基因双等位致病变异改变tRNA转录并导致髓鞘形成不足性脑白质营养不良：病例报告

期刊:Frontiers in Neurology

影响因子:2.8

doi:10.3389/fneur.2023.1254140

Macintosh, Julia; Perrier, Stefanie; Pinard, Maxime; Tran, Luan T; Guerrero, Kether; Prasad, Chitra; Prasad, Asuri N; Pastinen, Tomi; Thiffault, Isabelle; Coulombe, Benoit; Bernard, Geneviève

发表日期：2023

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Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci

肉瘤中反复发生的染色体易位形成巨型复合物，导致 NuA4/TIP60 错误定位到 Polycomb 靶位点。

期刊:Genes & Development

影响因子:7.7

doi:10.1101/gad.348982.121

Sudarshan, Deepthi; Avvakumov, Nikita; Lalonde, Marie-Eve; Alerasool, Nader; Joly-Beauparlant, Charles; Jacquet, Karine; Mameri, Amel; Lambert, Jean-Philippe; Rousseau, Justine; Lachance, Catherine; Paquet, Eric; Herrmann, Lara; Thonta Setty, Samarth; Loehr, Jeremy; Bernardini, Marcus Q; Rouzbahman, Marjan; Gingras, Anne-Claude; Coulombe, Benoit; Droit, Arnaud; Taipale, Mikko; Doyon, Yannick; Côté, Jacques

发表日期：2022

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De novo variants in POLR3B cause ataxia, spasticity, and demyelinating neuropathy

POLR3B基因的新生突变会导致共济失调、痉挛和脱髓鞘性神经病变。

期刊:American Journal of Human Genetics

影响因子:8.1

doi:10.1016/j.ajhg.2020.12.002

Djordjevic, Djurdja; Pinard, Maxime; Gauthier, Marie-Soleil; Smith-Hicks, Constance; Hoffman, Trevor L; Wolf, Nicole I; Oegema, Renske; van Binsbergen, Ellen; Baskin, Berivan; Bernard, Geneviève; Fribourg, Sébastien; Coulombe, Benoit; Yoon, Grace

发表日期：2021

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Analysis of the SARS-CoV-2-host protein interaction network reveals new biology and drug candidates: focus on the spike surface glycoprotein and RNA polymerase

对 SARS-CoV-2 与宿主蛋白相互作用网络的分析揭示了新的生物学机制和候选药物：重点关注刺突表面糖蛋白和 RNA 聚合酶

期刊:Expert Opinion on Drug Discovery

影响因子:4.9

doi:10.1080/17460441.2021.1909566

Sokullu, Esen; Pinard, Maxime; Gauthier, Marie-Soleil; Coulombe, Benoit

发表日期：2021

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