日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Biophysical Modeling Elucidates Mechanistic Principles for Rational Molecular Glue Design

生物物理建模阐明了合理分子胶设计的机制原理

Chae, Seok Joo; DeBonis, Jonathon; Quinlan, Joseph; Richards, Ryan; Wang, Junmin; Gutierrez, Gustavo; Tart, Jonathan; Couturier, Maxime; Martinez Cuesta, Sergio; Jin, Meizhong; Igoshin, Oleg A

Structural Studies of βTrCP Reveal Plasticity in Binding Modes of Consensus and Nonconsensus Degrons

βTrCP的结构研究揭示了其与共有序列和非共有序列降解子结合模式的可塑性。

Collie, Gavin W; Mak, Hazel; Acebrón-García-de-Eulate, Marta; Argyrou, Argyrides; Couturier, Maxime; Cuomo, Maria Emanuela; O Donovan, Daniel H; Russell, Isabella C; Wells, Geoffrey; Winter-Holt, Jon

A Complete Mechanistic Framework for Molecular Glue Characterization

分子胶表征的完整机理框架

Couturier, Maxime; Guilbert, Ryan; Clarkson, Paul; Argyrou, Argyrides

Focused Structure-Based Virtual Screening Identifies Novel Inhibitors of SOS1

基于结构的虚拟筛选鉴定出SOS1的新型抑制剂

Bonomo, Silvia; Gibault, Floriane; Bagal, Sharan K; Blackwell, J Henry; Breed, Jason; Collie, Gavin W; Couturier, Maxime; Diène, Coura; Di Fruscia, Paolo; Gray, Sean; Hughes, Craig; Jeyaharan, Dhadchayini; Kettle, Jason G; Milbradt, Alexander G; Northall, Sarah; Peters, Katherine; Stubbs, Christopher J; Underwood, Elizabeth; Chen, Yunhua; Hao, Haie; Lainchbury, Michael D

A high-throughput compatible workflow for the biochemical identification and characterization of molecular glues.

用于分子胶的生化鉴定和表征的高通量兼容工作流程

Guilbert Ryan, Couturier Maxime, Si Yuanyuan, Donovan Daniel O', Longmire David, Mak Hazel, Clarkson Paul, Argyrou Argyrides

Revision in the first steps of the biosynthesis of the red antibiotic prodigiosin: use of a synthetic thioester to validate a new intermediate

红色抗生素灵菌红素生物合成第一步的修正:利用合成硫酯验证新的中间体

Couturier, Maxime; Bhalara, Hiral D; Monson, Rita E; Salmond, George P C; Leeper, Finian J

Substrate Flexibility of the Flavin-Dependent Dihydropyrrole Oxidases PigB and HapB Involved in Antibiotic Prodigiosin Biosynthesis

参与抗生素灵菌红素生物合成的黄素依赖性二氢吡咯氧化酶PigB和HapB的底物灵活性

Couturier, Maxime; Bhalara, Hiral D; Chawrai, Suresh R; Monson, Rita; Williamson, Neil R; Salmond, George P C; Leeper, Finian J