日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Atom-level enzyme active site scaffolding using RFdiffusion2

利用 RFdiffusion2 进行原子级酶活性位点支架构建

Ahern, Woody; Yim, Jason; Tischer, Doug; Salike, Saman; Woodbury, Seth M; Kim, Donghyo; Kalvet, Indrek; Kipnis, Yakov; Coventry, Brian; Altae-Tran, Han Raut; Bauer, Magnus S; Barzilay, Regina; Jaakkola, Tommi S; Krishna, Rohith; Baker, David

Diffusing protein binders to intrinsically disordered proteins.

将蛋白质结合剂扩散到固有无序蛋白质上

Liu Caixuan, Wu Kejia, Choi Hojun, Han Hannah L, Zhang Xueli, Watson Joseph L, Ahn Green, Zhang Jason Z, Shijo Sara, Good Lydia L, Fischer Charlotte M, Bera Asim K, Kang Alex, Brackenbrough Evans, Coventry Brian, Hick Derrick R, Qamar Seema, Li Xinting, Decarreau Justin, Gerben Stacey R, Yang Wei, Goreshnik Inna, Vafeados Dionne, Wang Xinru, Lamb Mila, Murray Analisa, Kenny Sebastian, Bauer Magnus S, Hoofnagle Andrew N, Zhu Ping, Knowles Tuomas P J, Baker David

Tuning insulin receptor signaling using de novo-designed agonists.

利用全新设计的激动剂调节胰岛素受体信号传导。

Wang Xinru, Cardoso Sarah, Cai Kai, Venkatesh Preetham, Hung Albert, Ng Michelle, Hall Catherine, Coventry Brian, Lee David S, Chowhan Rishabh, Gerben Stacey, Li Jie, An Weidong, Hon Mara, Gao Michael, Liao Ya-Cheng, Accili Domenico, Choi Eunhee, Bai Xiao-Chen, Baker David

Computational design of sequence-specific DNA-binding proteins

序列特异性DNA结合蛋白的计算设计

Glasscock, Cameron J; Pecoraro, Robert J; McHugh, Ryan; Doyle, Lindsey A; Chen, Wei; Boivin, Olivier; Lonnquist, Beau; Na, Emily; Politanska, Yuliya; Haddox, Hugh K; Cox, David; Norn, Christoffer; Coventry, Brian; Goreshnik, Inna; Vafeados, Dionne; Lee, Gyu Rie; Gordân, Raluca; Stoddard, Barry L; DiMaio, Frank; Baker, David

De novo design of potent inhibitors of clostridial family toxins

从头设计高效梭菌毒素抑制剂

Ragotte, Robert J; Liang, Huazhu; Tam, John; Miletic, Sean; Berman, Jacob M; Palou, Roger; Weidle, Connor; Li, Zhijie; Glögl, Matthias; Beilhartz, Greg L; Carr, Kenneth D; Borst, Andrew J; Coventry, Brian; Wang, Xinru; Rubinstein, John L; Tyers, Mike; Schramek, Daniel; Melnyk, Roman A; Baker, David

Designed miniproteins potently inhibit and protect against MERS-CoV.

设计的微型蛋白质能有效抑制和抵抗中东呼吸综合征冠状病毒(MERS-CoV)

Ragotte Robert J, Tortorici M Alejandra, Catanzaro Nicholas J, Addetia Amin, Coventry Brian, Froggatt Heather M, Lee Jimin, Stewart Cameron, Brown Jack T, Goreshnik Inna, Sims Jeremiah N, Milles Lukas F, Wicky Basile I M, Glögl Matthias, Gerben Stacey, Kang Alex, Bera Asim K, Sharkey William, Schäfer Alexandra, Harkema Jack R, Baric Ralph S, Baker David, Veesler David

Computational design of pH-sensitive binders

pH敏感型粘合剂的计算设计

Ahn, Green; Coventry, Brian; Haefner, Ella; Sadre, Shayan; Hu, Jenny; Van, Mimosa; Huang, Buwei; Sappington, Isaac; Broerman, Adam J; Lichtenstein, Mauriz A; Glögl, Matthias; Goreshnik, Inna; Vafeados, Dionne; Baker, David

Computational design of metalloproteases

金属蛋白酶的计算设计

Chen, Anqi; Wu, Kejia; Choi, Hojae; Venkatesh, Preetham; Pellock, Samuel J; Hanikel, Nikita; Coventry, Brian; Kim, Donghyo; Woodbury, Seth M; Ji, Pengfei; Honda, Shingo; Li, Xinting; Gerben, Stacey; Chang, Lemuel; Yan, Xiao; Hyman, Anthony A; Hilvert, Donald; Baker, David

High-Throughput De Novo Protein Design Yields Novel Immunomodulatory Agonists.

高通量从头蛋白质设计产生新型免疫调节激动剂。

Abedi Mohamad, Expòsit Marc, Coventry Brian, Mathew Divij, Jain Shruti, Krishnakumar Aditya, Goreshnik Inna, Gray-Gaillard Sophie L, Lunn-Halbert Margaret, Yu Ta-Yi, Glögl Matthias, Mitchell Uma, Keshri Riya, Chun Jung Ho, Ruohola-Baker Hannele, Wherry E John, Baker David

Diffusing protein binders to intrinsically disordered proteins

将蛋白质结合剂扩散到固有无序蛋白

Liu, Caixuan; Wu, Kejia; Choi, Hojun; Han, Hannah; Zhang, Xulie; Watson, Joseph L; Shijo, Sara; Bera, Asim K; Kang, Alex; Brackenbrough, Evans; Coventry, Brian; Hick, Derrick R; Hoofnagle, Andrew N; Zhu, Ping; Li, Xingting; Decarreau, Justin; Gerben, Stacey R; Yang, Wei; Wang, Xinru; Lamp, Mila; Murray, Analisa; Bauer, Magnus; Baker, David