Cowley Shaun M相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Mutations on the surface of HDAC1 reveal molecular determinants of specific complex assembly and their requirement for gene regulation

HDAC1表面突变揭示了特定复合物组装的分子决定因素及其对基因调控的必要性。

期刊:Nucleic Acids Research

影响因子:13.1

doi:10.1093/nar/gkaf918

Alshehri, Ahmad; Baker, India-May; English, David M; Fairall, Louise; Collins, Mark O; Schwabe, John W R; Cowley, Shaun M

发表日期：2025

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Synthetic and structure-activity studies of SP2577 and TCP towards LSD1 targeting PROTACs

SP2577 和 TCP 对 LSD1 靶向 PROTAC 的合成及构效关系研究

期刊:RSC Medicinal Chemistry

影响因子:3.6

doi:10.1039/d5md00420a

Coulson, Megan E; Norris, James K S; Smith, Sean A; Smalley, Joshua P; Schwabe, John W R; Cowley, Shaun M; Hodgkinson, James T

发表日期：2025

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Targeted Degradation of Class 1 HDACs With PROTACs is Highly Effective at Inducing DLBCL Cell Death.

利用 PROTACs 靶向降解 1 类 HDACs 可高效诱导 DLBCL 细胞死亡

影响因子:1.2

doi:10.1002/jha2.70127

Alraddadi Abdullah, Smalley Joshua P, Alzahrani Wael, Saleh Anes, Al-Mansour Fares, He Buwei, Cao Thong H, Jayne Sandrine, Dyer Martin, Hodgkinson James T, Jones Donald J L, Cowley Shaun M, Macip Salvador

细胞生物学

发表日期：2025

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Cereblon-recruiting proteolysis targeting chimeras (PROTACs) can determine the selective degradation of HDAC1 over HDAC3

脑蛋白募集蛋白水解靶向嵌合体（PROTACs）可以决定HDAC1相对于HDAC3的选择性降解。

期刊:Chemical Communications

影响因子:4.2

doi:10.1039/d4cc05138f

Pavan, Aline R; Smalley, Joshua P; Patel, Urvashi; Pytel, Wiktoria A; Dos Santos, Jean Leandro; Cowley, Shaun M; Schwabe, John W R; Hodgkinson, James T

发表日期：2024

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MDM2 Antagonist Idasanutlin Reduces HDAC1/2 Abundance and Corepressor Partners but Not HDAC3.

MDM2拮抗剂Idasanutlin可降低HDAC1/2的丰度和辅阻遏物伙伴，但不会影响HDAC3

期刊:ACS Medicinal Chemistry Letters

doi:10.1021/acsmedchemlett.3c00449

Smalley Joshua P, Cowley Shaun M, Hodgkinson James T

发表日期：2024

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Bifunctional HDAC Therapeutics: One Drug to Rule Them All?

双功能 HDAC 疗法：一种药物就能解决所有问题？

期刊:Molecules

影响因子:4.6

doi:10.3390/molecules25194394

Smalley, Joshua P; Cowley, Shaun M; Hodgkinson, James T

发表日期：2020

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Acetylation & Co: an expanding repertoire of histone acylations regulates chromatin and transcription

乙酰化及其相关修饰：不断扩展的组蛋白酰化修饰调控染色质和转录

期刊:Essays in Biochemistry

影响因子:5.7

doi:10.1042/EBC20180061

Barnes, Claire E; English, David M; Cowley, Shaun M

发表日期：2019

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Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex

共抑制因子、共激活因子和通用转录因子：Sin3 组蛋白去乙酰化酶 (HDAC) 复合物的多重功能

期刊:Biochemical Journal

影响因子:4.3

doi:10.1042/BCJ20170314

Adams, Grace E; Chandru, Aditya; Cowley, Shaun M

发表日期：2018

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Sin3A recruits Tet1 to the PAH1 domain via a highly conserved Sin3-Interaction Domain

Sin3A 通过高度保守的 Sin3 相互作用域将 Tet1 募集到 PAH1 结构域。

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-018-32942-w

Chandru, Aditya; Bate, Neil; Vuister, Geerten W; Cowley, Shaun M

发表日期：2018

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Recombinant protein expression for structural biology in HEK 293F suspension cells: a novel and accessible approach

在HEK 293F悬浮细胞中表达重组蛋白用于结构生物学研究：一种新颖且易于操作的方法

期刊:Jove-Journal of Visualized Experiments

doi:10.3791/51897

Portolano, Nicola; Watson, Peter J; Fairall, Louise; Millard, Christopher J; Milano, Charles P; Song, Yun; Cowley, Shaun M; Schwabe, John W R

细胞生物学

发表日期：2014

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